Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

biliverdin 3-[2-[(E)-[(5E)-3-(2- carboxyethyl)-5-[(4...

Synonyms: Oocyan, biliverdine, uteroverdine, Biliverdin IXa, AC1NST1Q, ...

Hagiwara, Y. et al., Bauer, I. et al.

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Disease relevance of uteroverdine

Phycocyanobilin:ferredoxin oxidoreductase (PcyA) catalyzes the sequential reduction of the vinyl group of the D-ring and the A-ring of biliverdin IXalpha (BV) using ferredoxin to produce phycocyanobilin, a pigment used for light-harvesting and light-sensing in red algae and cyanobacteria [1].

High impact information on uteroverdine

Heme oxygenase (HO) catalyzes the oxidative cleavage of the alpha-mesocarbon of Fe-protoporphyrin-IX yielding equimolar amounts of biliverdin-IXa, iron, and carbon monoxide [2].
Unexpectedly, these movements localize the positive charges around the BV binding site, which may contribute to the proper binding of ferredoxin to PcyA [1].

References

Induced-fitting and electrostatic potential change of PcyA upon substrate binding demonstrated by the crystal structure of the substrate-free form. Hagiwara, Y., Sugishima, M., Takahashi, Y., Fukuyama, K. FEBS Lett. (2006) [Pubmed]
Expression pattern of heme oxygenase isoenzymes 1 and 2 in normal and stress-exposed rat liver. Bauer, I., Wanner, G.A., Rensing, H., Alte, C., Miescher, E.A., Wolf, B., Pannen, B.H., Clemens, M.G., Bauer, M. Hepatology (1998) [Pubmed]

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