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Chemical Compound Review

AC1NSVT6     [(1S,3E,7E)-4,8-dimethyl-13- methylidene-12...

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Disease relevance of Germacranolide


High impact information on Germacranolide

  • Costunolide, a germacranolide sesquiterpene lactone that exists in several medicinal plants, is known to be a possible anti-cancer and chemopreventive agent for tumorigenesis [2].
  • Serotonin release inhibition was shown to be significantly correlated with the content of the germacranolide sesquiterpene lactone, parthenolide, although other sesquiterpene lactones from this plant and other members of the Asteraceae were also shown to be active [3].

Analytical, diagnostic and therapeutic context of Germacranolide

  • Parthenolide, a germacranolide-type sesquiterpene lactone, was estimated in Tanacetum parthenium (L.) cultivated in Egypt by using colorimetric, planar chromatographic, and high-performance liquid chromatographic (HPLC) methods [4].


  1. Potent induction of apoptosis by germacranolide sesquiterpene lactones on human myeloid leukemia cells. Rivero, A., Quintana, J., Eiroa, J.L., López, M., Triana, J., Bermejo, J., Estévez, F. Eur. J. Pharmacol. (2003) [Pubmed]
  2. Potentiation of 1,25-dihydroxyvitamin D(3)-induced differentiation of human promyelocytic leukemia cells into monocytes by costunolide, a germacranolide sesquiterpene lactone. Kim, S.H., Kang, S.N., Kim, H.J., Kim, T.S. Biochem. Pharmacol. (2002) [Pubmed]
  3. A bioassay for inhibition of serotonin release from bovine platelets. Marles, R.J., Kaminski, J., Arnason, J.T., Pazos-Sanou, L., Heptinstall, S., Fischer, N.H., Crompton, C.W., Kindack, D.G., Awang, D.V. J. Nat. Prod. (1992) [Pubmed]
  4. Quantitative estimation of parthenolide in Tanacetum parthenium (L.) Schultz-Bip. cultivated in Egypt. El-Shamy, A.M., El-Hawary, S.S., Rateb, M.E. Journal of AOAC International (2007) [Pubmed]
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