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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Tanacetum

 
 
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Disease relevance of Tanacetum

 

High impact information on Tanacetum

  • Following admixture with the corresponding 2-14C-labeled internal standard, each substrate was converted to (+)-bornyl pyrophosphate and (-)-bornyl pyrophosphate by cell-free enzyme preparations from sage (Salvia officinalis) and tansy (Tanacetum vulgare), respectively [2].
  • While in vitro experiments with Tanacetum parthenium found inhibition of the expression of intercellular adhesion molecule-1, tumor necrosis factor alpha (TNF-alpha), interferon-gamma, IkappaB kinase, and a decrease in T-cell adhesion, to date human studies have not proven it useful in the treatment of RA [3].
  • In this study, we demonstrate that parthenolide, the predominant sesquiterpene lactone in European feverfew (Tanacetum parthenium), exerts potent inhibitory effects on the promoter activity of the iNOS gene in THP-1 cells [4].
  • Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by parthenolide, a predominant sesquiterpene lactone in Tanacetum parthenium: involvement of nuclear factor-kappaB [5].
  • The positive patch test reactions were to the plants Taraxacum officinale (dandelion) and Tanacetum vulgare (tansy) and to the pesticides folpet and captafol [6].
 

Anatomical context of Tanacetum

 

Associations of Tanacetum with chemical compounds

  • Effects of compounds extracted from Tanacetum microphyllum on arachidonic acid metabolism in cellular systems [8].
  • Tanacetum (Chrysanthemum) corymbosum seed oil--a rich source of a novel conjugated acetylenic acid [9].
  • Tansy (Tanacetum vulgare L.) produces an essential oil containing the optically pure monoterpene ketone, (-)-camphor, as a major constituent [10].
  • The sterols and triterpenes of tansy have not been previously reported; neither, to our knowledge, have the NMR spectra of the amyrins and the NMR and mass spectra of taraxasterol [11].
  • Dried tansy ragwort containing pyrrolizidine alkaloids was fed as 2.5% of a complete (control) diet to Hereford steers, with and without (basal) a mixture of additives [12].
 

Gene context of Tanacetum

  • There were significant differences in potency, with the tansy 6-hydroxyflavones less active than the feverfew 6-hydroxyflavonols as inhibitors of cyclo-oxygenase and 5-lipoxygenase [13].
  • 1. The in vitro effects of centaureidin and 5,3'-dihydroxy-4'-methoxy-7-carbomethoxyflavonol (Fig. 1), two anti-inflammatory flavonoids extracted from Tanacetum microphyllum DC., have been examined on both cyclooxygenase and lipoxygenase activity [14].

References

  1. Tansy ragwort poisoning in a horse in southern Ontario. de Lanux-Van Gorder, V. Can. Vet. J. (2000) [Pubmed]
  2. Stereochemistry at C-1 of geranyl pyrophosphate and neryl pyrophosphate in the cyclization to (+)- and (-)-bornyl pyrophosphate. Croteau, R., Felton, N.M., Wheeler, C.J. J. Biol. Chem. (1985) [Pubmed]
  3. Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. Setty, A.R., Sigal, L.H. Semin. Arthritis Rheum. (2005) [Pubmed]
  4. Inhibition by parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1. Fukuda, K., Hibiya, Y., Mutoh, M., Ohno, Y., Yamashita, K., Akao, S., Fujiwara, H. Biochem. Pharmacol. (2000) [Pubmed]
  5. Inhibition of interleukin-12 production in lipopolysaccharide-activated mouse macrophages by parthenolide, a predominant sesquiterpene lactone in Tanacetum parthenium: involvement of nuclear factor-kappaB. Kang, B.Y., Chung, S.W., Kim, T.S. Immunol. Lett. (2001) [Pubmed]
  6. Allergic contact and photoallergic contact dermatitis to plant and pesticide allergens. Mark, K.A., Brancaccio, R.R., Soter, N.A., Cohen, D.E. Archives of dermatology. (1999) [Pubmed]
  7. The activity of compounds extracted from feverfew on histamine release from rat mast cells. Hayes, N.A., Foreman, J.C. J. Pharm. Pharmacol. (1987) [Pubmed]
  8. Effects of compounds extracted from Tanacetum microphyllum on arachidonic acid metabolism in cellular systems. Silván, A.M., Abad, M.J., Bermejo, P., Villar, A. Planta Med. (1998) [Pubmed]
  9. Tanacetum (Chrysanthemum) corymbosum seed oil--a rich source of a novel conjugated acetylenic acid. Tsevegsuren, N., Christie, W.W., Lösel, D. Lipids (1998) [Pubmed]
  10. Biosynthesis of monoterpenes: demonstration of a geranyl pyrophosphate:(-)-bornyl pyrophosphate cyclase in soluble enzyme preparations from tansy (Tanacetum vulgare). Croteau, R., Shaskus, J. Arch. Biochem. Biophys. (1985) [Pubmed]
  11. Herbal remedies of the Maritime indians: sterols and triterpenes of Tanacetum vulgare L. (Tansy). Chandler, R.F., Hooper, S.N., Hooper, D.L., Jamieson, W.D., Lewis, E. Lipids (1982) [Pubmed]
  12. Effects of dietary supplementation with ethoxyquin, magnesium oxide, methionine hydroxy analog, and B vitamins on tansy ragwort (Senecio jacobaea) toxicosis in beef cattle. Cheeke, P.R., Schmitz, J.A., Lassen, E.D., Pearson, E.G. Am. J. Vet. Res. (1985) [Pubmed]
  13. The flavonoids of Tanacetum parthenium and T. vulgare and their anti-inflammatory properties. Williams, C.A., Harborne, J.B., Geiger, H., Hoult, J.R. Phytochemistry (1999) [Pubmed]
  14. The activity of flavonoids extracted from Tanacetum microphyllum DC. (Compositae) on soybean lipoxygenase and prostaglandin synthetase. Abad, M.J., Bermejo, P., Villar, A. Gen. Pharmacol. (1995) [Pubmed]
 
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