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MeSH Review

Plants, Medicinal

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Disease relevance of Plants, Medicinal


High impact information on Plants, Medicinal

  • Melatonin in feverfew and other medicinal plants [6].
  • In the synthesis of tropane alkaloids in several medicinal plants, the TRs reduce a carbonyl group of an alkaloid intermediate, tropinone, to hydroxy groups with different diastereomeric configurations [7].
  • Luteolin is a dietary flavonoid commonly found in some medicinal plants [8].
  • The antitumor activity of the sesquiterpene lactone parthenolide, an active ingredient of medicinal plants, is believed to be due to the inhibition of DNA binding of transcription factors NF-kappaB and STAT-3, reduction in MAP kinase activity and the generation of reactive oxygen [9].
  • Bioactivity-directed fractionation and isolation of medicinal herbs (primarily herbs of Chinese origin) have also led to many classes of cytotoxic compounds including polyphenolic compounds, sesquiterpene lactones, lignans, quassinoids, triterpene glucosides, flavonoids, colchicine derivatives, and quinone derivatives [10].

Chemical compound and disease context of Plants, Medicinal


Biological context of Plants, Medicinal


Anatomical context of Plants, Medicinal


Associations of Plants, Medicinal with chemical compounds


Gene context of Plants, Medicinal


Analytical, diagnostic and therapeutic context of Plants, Medicinal


  1. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor. Stermitz, F.R., Lorenz, P., Tawara, J.N., Zenewicz, L.A., Lewis, K. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  2. Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity. Yip, K.H., Zheng, M.H., Feng, H.T., Steer, J.H., Joyce, D.A., Xu, J. J. Bone Miner. Res. (2004) [Pubmed]
  3. A comparison of human immunodeficiency virus type-1 protease inhibition activities by the aqueous and methanol extracts of Chinese medicinal herbs. Lam, T.L., Lam, M.L., Au, T.K., Ip, D.T., Ng, T.B., Fong, W.P., Wan, D.C. Life Sci. (2000) [Pubmed]
  4. Serum interleukin-6 level is a useful marker in evaluating therapeutic effects of levamisole and Chinese medicinal herbs on patients with oral lichen planus. Sun, A., Chia, J.S., Chang, Y.F., Chiang, C.P. J. Oral Pathol. Med. (2002) [Pubmed]
  5. A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs. Au, T.K., Lam, T.L., Ng, T.B., Fong, W.P., Wan, D.C. Life Sci. (2001) [Pubmed]
  6. Melatonin in feverfew and other medicinal plants. Murch, S.J., Simmons, C.B., Saxena, P.K. Lancet (1997) [Pubmed]
  7. Crystal structures of two tropinone reductases: different reaction stereospecificities in the same protein fold. Nakajima, K., Yamashita, A., Akama, H., Nakatsu, T., Kato, H., Hashimoto, T., Oda, J., Yamada, Y. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  8. Protein kinase C inhibition and x-linked inhibitor of apoptosis protein degradation contribute to the sensitization effect of luteolin on tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in cancer cells. Shi, R.X., Ong, C.N., Shen, H.M. Cancer Res. (2005) [Pubmed]
  9. Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase. Nakshatri, H., Rice, S.E., Bhat-Nakshatri, P. Oncogene (2004) [Pubmed]
  10. Novel antitumor agents from higher plants. Lee, K.H. Medicinal research reviews. (1999) [Pubmed]
  11. A flavonoid from medicinal plants blocks hepatitis B virus-e antigen secretion in HBV-infected hepatocytes. Shin, M.S., Kang, E.H., Lee, Y.I. Antiviral Res. (2005) [Pubmed]
  12. Effect of the traditional medicinal plants Rhazya stricta, Balanitis aegyptiaca and Haplophylum tuberculatum on paracetamol-induced hepatotoxicity in mice. Ali, B.H., Bashir, A.K., Rasheed, R.A. Phytotherapy research : PTR. (2001) [Pubmed]
  13. Antiviral evaluation of plants from Brazilian Atlantic Tropical Forest. Andrighetti-Fröhner, C.R., Sincero, T.C., da Silva, A.C., Savi, L.A., Gaido, C.M., Bettega, J.M., Mancini, M., de Almeida, M.T., Barbosa, R.A., Farias, M.R., Barardi, C.R., Simões, C.M. Fitoterapia (2005) [Pubmed]
  14. Involvement of HSP70 in resveratrol-induced apoptosis of human prostate cancer. Cardile, V., Scifo, C., Russo, A., Falsaperla, M., Morgia, G., Motta, M., Renis, M., Imbriani, E., Silvestre, G. Anticancer Res. (2003) [Pubmed]
  15. Screening of medicinal plants used in South African traditional medicine for genotoxic effects. Elgorashi, E.E., Taylor, J.L., Maes, A., van Staden, J., De Kimpe, N., Verschaeve, L. Toxicol. Lett. (2003) [Pubmed]
  16. Studies on the activities of tannins and related compounds of medicinal plants and drugs. III. Effects of various tannins and related compounds on adrenocorticotropic hormone-induced lipolysis and insulin-induced lipogenesis from glucose in fat cells. (2). Kimura, Y., Okuda, H., Okuda, T., Yoshida, T., Hatano, T., Arichi, S. Chem. Pharm. Bull. (1983) [Pubmed]
  17. Pharmacological activity of South American plants: effects on spontaneous in vivo lipid peroxidation. Desmarchelier, C.J., de Moraes Barros, S.B. Phytotherapy research : PTR. (2003) [Pubmed]
  18. Effects of morin on blood pressure and metabolic changes in fructose-induced hypertensive rats. Kang, D.G., Moon, M.K., Sohn, E.J., Lee, D.H., Lee, H.S. Biol. Pharm. Bull. (2004) [Pubmed]
  19. Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes. Kimura, Y., Okuda, H., Okuda, T., Hatano, T., Arichi, S. J. Nat. Prod. (1987) [Pubmed]
  20. Chinese medicinal herbs Muh-Shiang Bin-Lang-Wan increases the motility of sphincter of Oddi in anesthetized rabbits through activation of M1 muscarinic receptors. Kuo, Y.I., Chiu, J.H., Lin, J.G., Hsieh, C.L., Wu, C.W. Life Sci. (2003) [Pubmed]
  21. Studies on palauan medicinal herbs. II. Activation of mouse macrophages RAW 264.7 by Ongael, leaves of Phaleria cumingii (Meisn.) F. Vill. and its acylglucosylsterols. Matsuda, H., Tokunaga, M., Iwahashi, H., Naruto, S., Yagi, H., Masuko, T., Kubo, M. Biol. Pharm. Bull. (2005) [Pubmed]
  22. Effect of flavonoids from Spanish and Indian medicinal herbs on arachidonate metabolism in rat peritoneal leukocytes. Ferrándiz, M.L., Ramachandran Nair, A.G., Alcaraz, M.J. Die Pharmazie. (1990) [Pubmed]
  23. Effect of ethanol extracts of three Chinese medicinal plants with laxative properties on ion transport of the rat intestinal epithelia. Tsai, J.C., Tsai, S., Chang, W.C. Biol. Pharm. Bull. (2004) [Pubmed]
  24. Effects of ferulic acid on fertile and asthenozoospermic infertile human sperm motility, viability, lipid peroxidation, and cyclic nucleotides. Zheng, R.L., Zhang, H. Free Radic. Biol. Med. (1997) [Pubmed]
  25. Resveratrol analog (Z)-3,5,4'-trimethoxystilbene is a potent anti-mitotic drug inhibiting tubulin polymerization. Schneider, Y., Chabert, P., Stutzmann, J., Coelho, D., Fougerousse, A., Gossé, F., Launay, J.F., Brouillard, R., Raul, F. Int. J. Cancer (2003) [Pubmed]
  26. Natural occurrence of cancer-preventive geranylgeranoic acid in medicinal herbs. Shidoji, Y., Ogawa, H. J. Lipid Res. (2004) [Pubmed]
  27. Analysis of isoquinoline alkaloids in medicinal plants by capillary electrophoresis-mass spectrometry. Sturm, S., Stuppner, H. Electrophoresis (1998) [Pubmed]
  28. Differential inhibitory effects of protoberberines on sterol and chitin biosyntheses in Candida albicans. Park, K.S., Kang, K.C., Kim, J.H., Adams, D.J., Johng, T.N., Paik, Y.K. J. Antimicrob. Chemother. (1999) [Pubmed]
  29. Dioscorin isolated from Dioscorea alata activates TLR4-signaling pathways and induces cytokine expression in macrophages. Fu, S.L., Hsu, Y.H., Lee, P.Y., Hou, W.C., Hung, L.C., Lin, C.H., Chen, C.M., Huang, Y.J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  30. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. Subehan, n.u.l.l., Usia, T., Iwata, H., Kadota, S., Tezuka, Y. Journal of ethnopharmacology. (2006) [Pubmed]
  31. Bio-normalizer modulates interferon-gamma-induced nitric oxide production in the mouse macrophage cell line RAW 264.7. Kobuchi, H., Packer, L. Biochem. Mol. Biol. Int. (1997) [Pubmed]
  32. Inhibition of multidrug resistance of cancer cells by natural diterpenes, triterpenes and carotenoids. Molnár, J., Gyémánt, N., Tanaka, M., Hohmann, J., Bergmann-Leitner, E., Molnár, P., Deli, J., Didiziapetris, R., Ferreira, M.J. Curr. Pharm. Des. (2006) [Pubmed]
  33. Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis. Noreen, Y., Serrano, G., Perera, P., Bohlin, L. Planta Med. (1998) [Pubmed]
  34. Weight reduction by Chinese medicinal herbs may be related to inhibition of fatty acid synthase. Tian, W.X., Li, L.C., Wu, X.D., Chen, C.C. Life Sci. (2004) [Pubmed]
  35. Determination of carbamate insecticides in Chinese medicinal herbs by gas chromatography with a nitrogen-phosphorus detector. Wu, J., Li, L., Zou, Y. Journal of AOAC International. (2005) [Pubmed]
  36. Comparison of the chemical composition of extracts from Scutellaria lateriflora using accelerated solvent extraction and supercritical fluid extraction versus standard hot water or 70% ethanol extraction. Bergeron, C., Gafner, S., Clausen, E., Carrier, D.J. J. Agric. Food Chem. (2005) [Pubmed]
  37. Mutagenic activity of the pyrrolizidine alkaloids seneciphylline and senkirkine in Drosophila and their transfer into rat milk. Candrian, U., Lüthy, J., Graf, U., Schlatter, C. Food Chem. Toxicol. (1984) [Pubmed]
  38. Chips and Qi: microcomponent-based analysis in traditional Chinese medicine. Carles, M., Lee, T., Moganti, S., Lenigk, R., Tsim, K.W., Ip, N.Y., Hsing, I.M., Sucher, N.J. Fresenius' journal of analytical chemistry. (2001) [Pubmed]
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