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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Asteraceae

  • Both RAST results in 32 adults with summer symptoms previously diagnosed as allergic to Artemisia pollen, and cross-reactivity studies between H. annuus and other Compositae suggested that H. annuus pollen was the main allergen involved in the hypersensitivity reaction of those patients [1].
  • Potential allergens were found among the emitted monoterpenes and their importance in airborne Compositae dermatitis is discussed [2].
  • This report also revises data from a previous publication (Kaiser, A., 1999. Cloning and expression of a cDNA encoding homospermidine synthase from Senecio vulgaris (Asteraceae) in Escherichia coli. Plant J. 19. 195 201.) that is incorrect [3].
  • A decoction of Mikania cordata (Compositae) is commonly used for the treatment of gastric ulcer in the Rajbari district of Bangladesh. We have evaluated the anti-ulcerogenic effect of the alkaloidal fraction from the whole plant of M. cordata on diclofenac sodium-induced gastrointestinal lesion in rats [4].
  • Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells [5].

Psychiatry related information on Asteraceae


High impact information on Asteraceae

  • Irregular monoterpenes are common in Chrysanthemum cinerariaefolium and related members of the Asteraceae family [7].
  • A chloroplast DNA (cpDNA) restriction site analysis of Argyranthemum (Asteraceae: Anthemideae), the largest endemic genus of plants of any volcanic archipelago in the Atlantic Ocean, was performed to examine patterns of plant evolution in Macaronesia. cpDNA data indicated that Argyranthemum is a monophyletic group that has speciated recently [8].
  • Duplication and functional divergence in the chalcone synthase gene family of Asteraceae: evolution with substrate change and catalytic simplification [9].
  • We have recently isolated from Gerbera hybrida (Asteraceae) an unusual CHS-like gene, GCHS2, which codes for an enzyme with structural and enzymatic properties as well as ontogenetic distribution distinct from both CHS and SS [9].
  • Polyphyletic origin of pyrrolizidine alkaloids within the Asteraceae. Evidence from differential tissue expression of homospermidine synthase [10].

Chemical compound and disease context of Asteraceae


Biological context of Asteraceae


Anatomical context of Asteraceae


Associations of Asteraceae with chemical compounds


Gene context of Asteraceae

  • Here, we present genomic DNA fragments obtained by amplification with primers of a conserved region (amino acid positions 550-1,043) between the putative P. falciparum DHS gene ( dhs) and the HSS gene ( hss) from the plant Senecio vulgaris (Asteraceae) [29].
  • Taken together, compound 1 inhibits the production of NO and PGE2 at the transcription of iNOS and COX-2 genes, and would be responsible for the anti-inflammatory activities of the Ligularia fischeri [30].
  • The n-hexane extract of Bidens campylotheca Schultz Bip. ssp campylotheca (Compositae) showed significant in vitro inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO) [31].
  • (Compositae) the first intermediate in DMSP biosynthesis has been shown to be S-methylmethionine (SMM) (A.D. Hanson, J. Rivoal, L. Paquet, D.A. Gage [1994] Plant Physiol 105: 103-110) [32].
  • Diazepam (DZP) and a mixture of Chinese herbs customarily used to treat epilepsy were prepared as an aerosol under the trade name Aerosolum Diaiepami Compositae or Flvalscop (FVS) [33].

Analytical, diagnostic and therapeutic context of Asteraceae


  1. Sensitization to sunflower pollen: only an occupational allergy? Jiménez, A., Moreno, C., Martínez, J., Martínez, A., Bartolomé, B., Guerra, F., Palacios, R. Int. Arch. Allergy Immunol. (1994) [Pubmed]
  2. Airborne Compositae dermatitis: monoterpenes and no parthenolide are released from flowering Tanacetum parthenium (feverfew) plants. Christensen, L.P., Jakobsen, H.B., Paulsen, E., Hodal, L., Andersen, K.E. Arch. Dermatol. Res. (1999) [Pubmed]
  3. Cloning and expression of homospermidine synthase from Senecio vulgaris: a revision. Ober, D., Harms, R., Hartmann, T. Phytochemistry (2000) [Pubmed]
  4. The anti-ulcerogenic effect of an alkaloidal fraction from Mikania cordata on diclofenac sodium-induced gastrointestinal lesions in rats. Mosaddik, M.A., Alam, K.M. J. Pharm. Pharmacol. (2000) [Pubmed]
  5. Inhibitory effects of luteolin isolated from Ixeris sonchifolia Hance on the proliferation of HepG2 human hepatocellular carcinoma cells. Yee, S.B., Lee, J.H., Chung, H.Y., Im, K.S., Bae, S.J., Choi, J.S., Kim, N.D. Arch. Pharm. Res. (2003) [Pubmed]
  6. Neuropharmacological effect of the aqueous extract of Sphaeranthus senegalensis in mice. Amos, S., Adzu, B., Binda, L., Wambebe, C., Gamaniel, K. Journal of ethnopharmacology. (2001) [Pubmed]
  7. Chrysanthemyl diphosphate synthase: isolation of the gene and characterization of the recombinant non-head-to-tail monoterpene synthase from Chrysanthemum cinerariaefolium. Rivera, S.B., Swedlund, B.D., King, G.J., Bell, R.N., Hussey, C.E., Shattuck-Eidens, D.M., Wrobel, W.M., Peiser, G.D., Poulter, C.D. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Chloroplast DNA evidence of colonization, adaptive radiation, and hybridization in the evolution of the Macaronesian flora. Francisco-Ortega, J., Jansen, R.K., Santos-Guerra, A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  9. Duplication and functional divergence in the chalcone synthase gene family of Asteraceae: evolution with substrate change and catalytic simplification. Helariutta, Y., Kotilainen, M., Elomaa, P., Kalkkinen, N., Bremer, K., Teeri, T.H., Albert, V.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  10. Polyphyletic origin of pyrrolizidine alkaloids within the Asteraceae. Evidence from differential tissue expression of homospermidine synthase. Anke, S., Niemüller, D., Moll, S., Hänsch, R., Ober, D. Plant Physiol. (2004) [Pubmed]
  11. Lymphocyte subsets in patients with compositae oleoresin dermatitis and increased UVA sensitivity during treatment with azathioprine. Baadsgaard, O., Geisler, C., Plesner, T., Thestrup-Pedersen, K. Arch. Dermatol. Res. (1985) [Pubmed]
  12. Occupational allergic contact dermatitis caused by decorative plants. Lamminpää, A., Estlander, T., Jolanki, R., Kanerva, L. Contact Derm. (1996) [Pubmed]
  13. A 6-year experience with compositae mix. Hausen, B.M. Am. J. Contact Dermatitis (1996) [Pubmed]
  14. Isolation, partial characterisation and immunomodulating activities of polysaccharides from Vernonia kotschyana Sch. Bip. ex Walp. Nergard, C.S., Diallo, D., Michaelsen, T.E., Malterud, K.E., Kiyohara, H., Matsumoto, T., Yamada, H., Paulsen, B.S. Journal of ethnopharmacology. (2004) [Pubmed]
  15. T-lymphocyte cytokine profiles in compositae airborne dermatitis. Stingeni, L., Agea, E., Lisi, P., Spinozzi, F. Br. J. Dermatol. (1999) [Pubmed]
  16. H-protein of glycine decarboxylase is encoded by multigene families in Flaveria pringlei and F. cronquistii (Asteraceae). Kopriva, S., Bauwe, H. Mol. Gen. Genet. (1995) [Pubmed]
  17. Protective effect of bioactive fraction of Sphaeranthus indicus Linn. against cyclophosphamide induced suppression of humoral immunity in mice. Bafna, A.R., Mishra, S.H. Journal of ethnopharmacology. (2006) [Pubmed]
  18. Pharmacokinetic study of iodine-labeled silibinins in rat. Skottová, N., SVagera, Z., Vecera, R., Urbánek, K., Jegorov, A., Simánek, V. Pharmacol. Res. (2001) [Pubmed]
  19. Ixeris dentata extract maintains glutathione concentrations in mouse brain tissue under oxidative stress induced by kainic acid. Oh, S.H., Sung, T.H., Kim, M.R. Journal of medicinal food. (2003) [Pubmed]
  20. Photoinactivation of human erythrocyte enzymes by alpha-terthienyl and phenylheptatriyne, naturally occurring compounds in the Asteraceae. Yamamoto, E., Wat, C.K., MacRae, W.D., Towers, G.H., Chan, C.F. FEBS Lett. (1979) [Pubmed]
  21. Xanthorrhizol induces endothelium-independent relaxation of rat thoracic aorta. Campos, M.G., Oropeza, M.V., Villanueva, T., Aguilar, M.I., Delgado, G., Ponce, H.A. Life Sci. (2000) [Pubmed]
  22. A cytotoxic diterpene from Alomia myriadenia. Zani, C.L., Alves, T.M., Queiróz, R., Fontes, E.S., Shin, Y.G., Cordell, G.A. Phytochemistry (2000) [Pubmed]
  23. Effect of seneciphylline and senecionine on hepatic drug metabolizing enzymes in rats. Kakrani, H.K., Kalyani, G.A. Journal of ethnopharmacology. (1984) [Pubmed]
  24. Novel hypotensive agents from Verbesina caracasana: structure, synthesis and pharmacology. Botta, B., Carmignani, M., Volpe, A.R., Botta, M., Corelli, F., Delle Monache, G. Current medicinal chemistry. (2003) [Pubmed]
  25. A bHLH transcription factor mediates organ, region and flower type specific signals on dihydroflavonol-4-reductase (dfr) gene expression in the inflorescence of Gerbera hybrida (Asteraceae). Elomaa, P., Mehto, M., Kotilainen, M., Helariutta, Y., Nevalainen, L., Teeri, T.H. Plant J. (1998) [Pubmed]
  26. Dimethylsulfoniopropionate biosynthesis in Spartina alterniflora1. Evidence that S-methylmethionine and dimethylsulfoniopropylamine are intermediates. Kocsis, M.G., Nolte, K.D., Rhodes, D., Shen, T.L., Gage, D.A., Hanson, A.D. Plant Physiol. (1998) [Pubmed]
  27. Partial purification, kinetic analysis, and amino acid sequence information of a flavonol 3-O-methyltransferase from Serratula tinctoria. Huang, T.S., Anzellotti, D., Dedaldechamp, F., Ibrahim, R.K. Plant Physiol. (2004) [Pubmed]
  28. Transgenic production of epoxy fatty acids by expression of a cytochrome P450 enzyme from Euphorbia lagascae seed. Cahoon, E.B., Ripp, K.G., Hall, S.E., McGonigle, B. Plant Physiol. (2002) [Pubmed]
  29. Targeting enzymes involved in spermidine metabolism of parasitic protozoa--a possible new strategy for anti-parasitic treatment. Kaiser, A., Gottwald, A., Maier, W., Seitz, H.M. Parasitol. Res. (2003) [Pubmed]
  30. Furanoligularenone, an eremophilane from Ligularia fischeri, inhibits the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells. Hwang, B.Y., Lee, J.H., Koo, T.H., Kim, H.S., Hong, Y.S., Ro, J.S., Lee, K.S., Lee, J.J. Planta Med. (2002) [Pubmed]
  31. Anti-inflammatory active polyacetylenes from Bidens campylotheca. Redl, K., Breu, W., Davis, B., Bauer, R. Planta Med. (1994) [Pubmed]
  32. Evidence implicating dimethylsulfoniopropionaldehyde as an intermediate in dimethylsulfoniopropionate biosynthesis. James, F., Paquet, L., Sparace, S.A., Gage, D.A., Hanson, A.D. Plant Physiol. (1995) [Pubmed]
  33. Rapid arrest of seizures with an inhalation aerosol containing diazepam. Xi, L.Y., Zheng, W.M., Zhen, S.M., Xian, N.S. Epilepsia (1994) [Pubmed]
  34. Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook. Xia, Q., Chou, M.W., Lin, G., Fu, P.P. Chem. Res. Toxicol. (2004) [Pubmed]
  35. Search for chlorinated sesquiterpene lactones in the neurotoxic thistle Centaurea solstitialis by liquid chromatography-mass spectrometry, and model studies on their possible artifactual formation. Hamburger, M., Wolfender, J.L., Hostettmann, K. Nat. Toxins (1993) [Pubmed]
  36. Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart. Gamberini, M.T., Skorupa, L.A., Souccar, C., Lapa, A.J. Mem. Inst. Oswaldo Cruz (1991) [Pubmed]
  37. Patch test sensitization to Compositae mix, sesquiterpene-lactone mix, Compositae extracts, laurel leaf, Chlorophorin, Mansonone A, and dimethoxydalbergione. Kanerva, L., Estlander, T., Alanko, K., Jolanki, R. Am. J. Contact Dermatitis (2001) [Pubmed]
  38. Experimental study on relationship between exogenous estrogen and breast cancer risk. Zeng, X., Yao, Z. Chin. Med. J. (1997) [Pubmed]
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