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Chemical Compound Review:

Spinosin 6-[(2S,3S,4R,5R,6R)-4,5- dihydroxy-6...

Synonyms:

Kawashima, K. et al., Li, Y.J. et al., Li, Y.J. et al., Li, Y. et al.

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High impact information on Spinosin

Spinosin from Semen Ziziphi Spinosae, ferulic acid from Rhizoma Chuanxiong, mangiferin from Rhizoma Anemarrhenae and glycyrrhizic acid from Radix Glycyrrhizae were selected as quality control indices [1].
The HPLC method developed has been applied to determine the pharmacokinetics of spinosin in rat plasma after having taken Suanzaoren decoction [2].
In blood, spinosin and feruloyl spinosin were found after the oral administration of a butanol extract of Sansohnin [3].

Associations of Spinosin with other chemical compounds

AIM: To study the pharmacokinetics of spinosin in rat plasma after oral administration of Suanzaoren extract using sulfamethoxazole (SMZ) as internal standard by RP-HPLC method [4].

Analytical, diagnostic and therapeutic context of Spinosin

Pharmacokinetic study on spinosin in rat plasma after oral administration of suanzaoren extract at a single dose [4].
It was assumed that spinosin and feruloyl spinosin circulated through the intestine and liver, therefore, these results will provide support for the sedative and hypnotic use of this crude drug in Oriental medicine [3].

References

Study on the therapeutic material basis of traditional chinese medicinal preparation suanzaoren decoction. Li, Y.J., Bi, K.S. Chem. Pharm. Bull. (2006) [Pubmed]
Determination of spinosin in rat plasma by reversed-phase high-performance chromatography after oral administration of Suanzaoren decoction. Li, Y., Liang, X., Xiao, H., Bi, K. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. (2003) [Pubmed]
Pharmacological properties of traditional medicines. XXIII. Searching for active compounds in the blood and bile of rats after oral administrations of extracts of sansohnin [symbol: see text]. Kawashima, K., Saito, K., Yamada, A., Obara, S., Ozaki, T., Kano, Y. Biol. Pharm. Bull. (1997) [Pubmed]
Pharmacokinetic study on spinosin in rat plasma after oral administration of suanzaoren extract at a single dose. Li, Y.J., Liang, X.M., Xiao, H.B., Bi, K.S. Yao Xue Xue Bao (2003) [Pubmed]

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