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Chemical Compound Review:

Stilbamidine 4-[(E)-2-(4- carbamimidoylphenyl) ethenyl]be...

Synonyms: Stilbamidinum, CHEMBL142304, SureCN208655, CCG-36712, NSC-35605, ...

Mesa-Valle, C.M. et al., Utz, J.P., Newsom, B.D. et al.

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Disease relevance of BA 2652

The second drug with efficacy was stilbamidine, and its currently available successor, hydroxystilbamidine isethionate, still has a role in therapy of some patients with nonprogressive blastomycosis of the skin [1].

High impact information on BA 2652

Amphotericin B was the mainstay of drug therapy, but upon occasion stilbamidine, penicillin, sulfonamides, and other agents were useful in specific circumstances [2].
The cytotoxicity assays on the macrophage cell line J-774 showed high cytotoxicity for the salt [PtIVBr6]H2 (stilbamidine) with a percentage of specific 51Cr release of 58.2% at 24 h of incubation and 100 microg/ml [3].

References

Chemotherapy for the systemic mycoses: the prelude to ketoconazole. Utz, J.P. Rev. Infect. Dis. (1980) [Pubmed]
Pulmonary fungal infection. Survey of 159 cases with surgical implications. Newsom, B.D., Hardy, J.D. J. Thorac. Cardiovasc. Surg. (1982) [Pubmed]
In vitro and in vivo activity of two Pt(IV) salts against leishmania donovani. Mesa-Valle, C.M., Rodriguez-Cabezas, M.N., Moraleda-Lindez, V., Craciunescu, D., Sanchez-Moreno, M., Osuna, A. Pharmacology (1998) [Pubmed]

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