Disease relevance of LS-1091

• The treated females consumed 273.6, 545.7, and 939.3 mg FD&C Red No. 40 per kg body weight per day, respectively, for the three dose levels [1].
• Developmental toxicity and psychotoxicity of FD and C red dye No. 40 (allura red AC) in rats [2].

Psychiatry related information on LS-1091

• There were few adverse effects of Allura Red AC on either movement activity or maze learning in F1 generation mice, compared with controls in each sex [3].

High impact information on LS-1091

• Eight synthetic food colorants (Amaranth, Brilliant Blue, Indigo Carmine, New Red, Ponceau 4R, Sunset Yellow, Tartrazine, Allura Red) were determined by high-performance ion chromatography on an anion-exchange analytical column with very low hydrophobicity and visible absorbance detection [4].
• FD&C Red No. 40 in the drinking water at a level of 0, 0.2, 0.4, or 0.7% was available ad libitum to female Osborne-Mendel rats throughout gestation [1].
• Determination of p-cresidine in FD&C red no. 40 by the diazotization and coupling procedure followed by reversed-phase high-performance liquid chromatography [5].
• Adsorptive voltammetric peak current showed a linear response for Allura Red in the concentration range of 2.5 x 10(-8) to 2.0 x 10(-7) mol/L (r = 0.998) [6].
• Optimum chromatographic separation of SUN and TAR with allura red as the internal standard (IS) was obtained by using a Waters Symmetry C18 column, 5 microm, 4.6 x 250 mm, and 0.2 M acetate buffer (pH 5)-acetonitrile-methano-bidistilled water (55 + 20 + 15 + 10, v/v) as the mobile phase at a flow rate of 1.9 mL/min [7].

Biological context of LS-1091

• There were few adverse effects of Allura Red AC on either litter size or weight, and ratio of male to female was significantly reduced in the lowest dosed group [3].

References