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MeSH Review

Maze Learning

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Disease relevance of Maze Learning


Psychiatry related information on Maze Learning


High impact information on Maze Learning


Chemical compound and disease context of Maze Learning


Biological context of Maze Learning


Anatomical context of Maze Learning


Gene context of Maze Learning

  • Music-exposed mice completed a maze learning task with fewer errors than the white noise-exposed mice and had lower levels of BDNF and higher levels of TrkB and PDK1 in the cortex [23].
  • The Morris water maze learning and the LTP in the CA1 area of the hippocampal slice were observed in wild-type mice and mutant mice lacking D-amino-acid oxidase [24].
  • Reciprocal changes in expression of mRNA for nerve growth factor and its receptors TrkA and LNGFR in brain of aged rats in relation to maze learning deficits [25].
  • We report that while episodes of oscillatory activity are found at various frequencies, most of the rhythmic activity during virtual maze learning occurs within the theta band [26].
  • Septal-diagonal band grafts improved open field habituation (within trial decline of ambulatory activity) and radial maze learning; the former was observed only in S16 rats, whereas the latter was observed only in S14 rats [27].

Analytical, diagnostic and therapeutic context of Maze Learning


  1. Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Lee, G.D., Longo, D.L., Wang, Y., Rifkind, J.M., Abdul-Raman, L., Mamczarz, J.A., Duffy, K.B., Spangler, E.L., Taub, D.D., Mattson, M.P., Ingram, D.K. Clin. Cancer Res. (2006) [Pubmed]
  2. Induced PKU in rats: effects of age and melatonin treatment. Butcher, R.E., Vorhees, C.V., Kindt, C.W., Kazmaier-Novak, K.J., Berry, H.K. Pharmacol. Biochem. Behav. (1977) [Pubmed]
  3. Graft-induced behavioral recovery in an animal model of Huntington disease. Isacson, O., Dunnett, S.B., Björklund, A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  4. Effects of septal and/or raphe cell suspension grafts on hippocampal choline acetyltransferase activity, high affinity synaptosomal uptake of choline and serotonin, and behavior in rats with extensive septohippocampal lesions. Cassel, J.C., Neufang, B., Kelche, C., Aiple, F., Will, B.E., Hertting, G., Jackisch, R. Brain Res. (1992) [Pubmed]
  5. Pre-training blocks the improving effect of tetrahydroaminoacridine and D-cycloserine on spatial navigation performance in aged rats. Aura, J., Riekkinen, P. Eur. J. Pharmacol. (2000) [Pubmed]
  6. Complementary memory storage sites in mice: their development as affected by the competitive NMDA receptor antagonist, CPP. Church, A.C., Flexner, J.B., Flexner, L.B. Pharmacol. Biochem. Behav. (1995) [Pubmed]
  7. Impaired maze learning and cerebral glucose utilization in aged hypertensive rats. Mori, S., Kato, M., Fujishima, M. Hypertension (1995) [Pubmed]
  8. A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. Luo, Y., Long, J.M., Lu, C., Chan, S.L., Spangler, E.L., Mascarucci, P., Raz, A., Longo, D.L., Mattson, M.P., Ingram, D.K., Weng, N.P. J. Neurochem. (2002) [Pubmed]
  9. Chronic nimodipine treatment in aged rats: analysis of motor and cognitive effects and muscarinic-induced striatal dopamine release. Ingram, D.K., Joseph, J.A., Spangler, E.L., Roberts, D., Hengemihle, J., Fanelli, R.J. Neurobiol. Aging (1994) [Pubmed]
  10. Delayed maze-learning in rats after prenatal exposure to clorazepate. Pascuzzi Jackson, V., DeMyer, W., Hingtgen, J. Arch. Neurol. (1980) [Pubmed]
  11. Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition. Devan, B.D., Bowker, J.L., Duffy, K.B., Bharati, I.S., Jimenez, M., Sierra-Mercado, D., Nelson, C.M., Spangler, E.L., Ingram, D.K. Psychopharmacology (Berl.) (2006) [Pubmed]
  12. Neuroprotective concentrations of the N-methyl-D-aspartate open-channel blocker memantine are effective without cytoplasmic vacuolation following post-ischemic administration and do not block maze learning or long-term potentiation. Chen, H.S., Wang, Y.F., Rayudu, P.V., Edgecomb, P., Neill, J.C., Segal, M.M., Lipton, S.A., Jensen, F.E. Neuroscience (1998) [Pubmed]
  13. Cognitive impairment and synaptosomal choline uptake in rats following impact acceleration injury. Schmidt, R.H., Scholten, K.J., Maughan, P.H. J. Neurotrauma (2000) [Pubmed]
  14. Differential ethanol intake in Tryon maze-bright and Tryon maze-dull rats: implications for the validity of the animal model of selectively bred rats for high ethanol consumption. Amit, Z., Smith, B.R. Psychopharmacology (Berl.) (1992) [Pubmed]
  15. Intakes of dietary docosahexaenoic acid ethyl ester and egg phosphatidylcholine improve maze-learning ability in young and old mice. Lim, S.Y., Suzuki, H. J. Nutr. (2000) [Pubmed]
  16. Insulin receptor signaling in long-term memory consolidation following spatial learning. Dou, J.T., Chen, M., Dufour, F., Alkon, D.L., Zhao, W.Q. Learn. Mem. (2005) [Pubmed]
  17. Sex differences in the acquisition of a radial maze task in the CD-1 mouse. LaBuda, C.J., Mellgren, R.L., Hale, R.L. Physiol. Behav. (2002) [Pubmed]
  18. Effect of the novel high affinity choline uptake enhancer 2-(2-oxopyrrolidin-1-yl)-N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b] quinolin-4-yl)acetoamide on deficits of water maze learning in rats. Bessho, T., Takashina, K., Tabata, R., Ohshima, C., Chaki, H., Yamabe, H., Egawa, M., Tobe, A., Saito, K. Arzneimittel-Forschung. (1996) [Pubmed]
  19. Involvement of dopamine D(2) receptors in complex maze learning and acetylcholine release in ventral hippocampus of rats. Umegaki, H., Munoz, J., Meyer, R.C., Spangler, E.L., Yoshimura, J., Ikari, H., Iguchi, A., Ingram, D.K. Neuroscience (2001) [Pubmed]
  20. Water maze learning and forebrain mRNA expression of the neural cell adhesion molecule L1. Venero, C., Tilling, T., Hermans-Borgmeyer, I., Herrero, A.I., Schachner, M., Sandi, C. J. Neurosci. Res. (2004) [Pubmed]
  21. Morris water maze learning in two rat strains increases the expression of the polysialylated form of the neural cell adhesion molecule in the dentate gyrus but has no effect on hippocampal neurogenesis. Van der Borght, K., Wallinga, A.E., Luiten, P.G., Eggen, B.J., Van der Zee, E.A. Behav. Neurosci. (2005) [Pubmed]
  22. Graft-induced learning impairment despite graft-enhanced cholinergic functions in the hippocampus of rats with septohippocampal lesions. Cassel, J.C., Kelche, C., Hornsperger, J.M., Jackisch, R., Hertting, G., Will, B.E. Brain Res. (1990) [Pubmed]
  23. Exposure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults. Chikahisa, S., Sei, H., Morishima, M., Sano, A., Kitaoka, K., Nakaya, Y., Morita, Y. Behav. Brain Res. (2006) [Pubmed]
  24. Spatial learning and long-term potentiation of mutant mice lacking D-amino-acid oxidase. Maekawa, M., Watanabe, M., Yamaguchi, S., Konno, R., Hori, Y. Neurosci. Res. (2005) [Pubmed]
  25. Reciprocal changes in expression of mRNA for nerve growth factor and its receptors TrkA and LNGFR in brain of aged rats in relation to maze learning deficits. Hasenöhrl, R.U., Söderstróm, S., Mohammed, A.H., Ebendal, T., Huston, J.P. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1997) [Pubmed]
  26. Distinct patterns of brain oscillations underlie two basic parameters of human maze learning. Caplan, J.B., Madsen, J.R., Raghavachari, S., Kahana, M.J. J. Neurophysiol. (2001) [Pubmed]
  27. Graft-induced behavioral recovery from subcallosal septohippocampal damage in rats depends on maturity stage of donor tissue. Cassel, J.C., Kelche, C., Peterson, G.M., Ballough, G.P., Goepp, I., Will, B. Neuroscience (1991) [Pubmed]
  28. Intrahypothalamic microinjections of noradrenaline with and without induction of the alimentary drive as a reward in a T maze learning in rats. Cytawa, J., Jurkowlaniec, E. Acta neurobiologiae experimentalis. (1979) [Pubmed]
  29. Effects of local infusion of methylmercury on the rat brain: GFAP immunohistochemistry and water maze learning. Juárez, B.I., Martínez, L.M., Castillo, C.G., Giordano, M., García, C., Jiménez-Capdeville, M.E. Proc. West. Pharmacol. Soc. (2003) [Pubmed]
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