Disease relevance of Indigotindisulfonate sodium

• Polyps from the first 12 patients (phase 1) were sprayed with 10 mL of 0.2% indigo carmine dye, and a biopsy was performed or a specimen removed and submitted for histological analysis [1].
• Pancolonic indigo carmine dye spraying for the detection of dysplasia in ulcerative colitis [2].
• To investigate the potential mechanisms by which indigo carmine produces hypertension, we tested the hypothesis that indigo carmine inhibits endothelium-dependent vasodilation and determined the possible site of the inhibition (endothelium versus smooth muscle) [3].
• The kinetics of reduction of indigocarmine-dye-oxidized Fe protein of nitrogenase from Klebsiella pneumoniae (Kp2ox) by sodium dithionite in the presence and absence of MgADP were studied by stopped-flow spectrophotometry at 23 degrees C and at pH 7 [4].
• Hypotension after indigo carmine [5].

High impact information on Indigotindisulfonate sodium

• This study was designed to report our experience using a high-resolution colonoscope combined with indigo carmine dye to diagnosis diminutive colorectal polyps [1].
• We conclude that bleaching of indigo carmine cannot be used to invoke ozone production by neutrophils [6].
• Methylene blue but not indigo carmine causes DNA damage to colonocytes in vitro and in vivo at concentrations used in clinical chromoendoscopy [7].
• METHODS: Consecutive patients attending for routine colonoscopy were randomised to either pan-chromoscopy using 0.5% indigo carmine (IC) or targeted chromoscopy (control group) [8].
• Three types of mucosal patterns were noted within the columnar mucosa after spraying indigo carmine and using MCE: ridged/villous pattern, circular pattern, and irregular/distorted pattern [9].

Chemical compound and disease context of Indigotindisulfonate sodium

• In order to examine these possibilities, indigo carmine was injected into the bladder of 19-day fetuses previously exposed to ethanol on Day 10 of gestation and the presence of hydronephrosis and/or reflux determined [10].
• We aimed to compare the accuracy of predicting polyp histology at magnification colonoscopy, using acetic acid and indigo carmine, either alone or in combination [11].
• Reductive and hydrolytic activities on two food colours namely metanil yellow and indigo carmine by different strains of enteric bacteria were evaluated [12].

Biological context of Indigotindisulfonate sodium

• Indigo carmine inhibits endothelium-dependent and -independent vasodilation [3].
• Thus, indigo carmine may elevate blood pressure by interfering with these nitric oxide-mediated vasodilatory mechanisms [3].
• The commonly encountered cardiovascular effects of intravenous indigo carmine administration is transient alpha-receptor stimulation, namely increased total peripheral resistance, diastolic and systolic blood pressure, and central venous pressure with decreased cardiac output, stroke volume and heart rate [13].
• Indigo carmine may be safely used as a tissue stain or vasography agent with a minimal effect on sperm motility in dilutions of 4x and higher [14].
• Under careful sonographic control and using indigo carmine as a marker, a technique for amniocentesis in a triplet gestation is presented [15].

Anatomical context of Indigotindisulfonate sodium

• In addition, indigo carmine appears to inhibit vascular smooth muscle guanylyl cyclase [3].
• The major action of indigo carmine appears to be at the level of nitric oxide generation and/or release from the endothelial cell [3].
• Function of the minor duodenal papilla in pancreas divisum as determined by duodenoscopy using indigo carmine dye and a pH sensor [16].
• After a careful examination of the whole colon, a defined segment of the sigmoid colon and rectum (0-30 cm from the anal verge) was stained with 20 ml of 0.2% indigocarmine solution with a spraying catheter [17].
• A volume of 0.1-0.3 ml 1 per cent indigo carmine solution was injected directly into lymphatic vessels of the gallbladder in eight patients and into lymph nodes (cystic node or pericholedochal nodes) in 13 patients during radical surgery for biliary tract cancer [18].

Associations of Indigotindisulfonate sodium with other chemical compounds

• In contrast, indigo carmine (10(-4) mol/L) had no effect on the vasodilation induced by isoproterenol (an activator of adenylyl cyclase), indicating that indigo carmine selectively inhibits nitric oxide-mediated responses [3].
• The influence of the aerosols in vivo was measured in human volunteers as changes in mucus transport time (MTT) with the indigocarmine/saccharine sodium method [19].
• The effects of 4 permitted food dyes, i.e., fast green FCF, indigo carmine, orange G and tartrazine, and the non-permitted dye metanil yellow on chromosomes of Allium cepa are reported [20].
• Effect of methylene blue, indigo carmine, and Renografin on human sperm motility [14].
• Anthrachinonic dyes (Lanaset Blue 2R, Terasil Pink 2GLA), some azo dyes, Indigo Carmine, and the triphenylmethane dye Crystal Violet were efficiently decolorized [21].

Gene context of Indigotindisulfonate sodium

• Analysis of the conversion of indigo into indigo carmine dye using SERRS [22].
• The reaction of pancreatic juice excreted via the minor papilla was evaluated after intravenous administration of secretin, by observing the repulsion of indigo carmine dye scattered on the surface of the minor papilla [16].
• METHODS: In 21 men who had dilated seminal vesicles and/or midline cysts on TRUS, a mixture of contrast media and indigocarmine was injected and then pelvic radiographs were taken [23].
• Indigo carmine was injected to ensure sampling of both amniotic sacs [24].
• These results indicate that indigocarmine is reduced by P450 reductase to its leuco form, and superoxide radical is produced by autoxidation of the leuco form, through a mechanism known as futile redox cycling [25].

Analytical, diagnostic and therapeutic context of Indigotindisulfonate sodium

• EMR was performed for lesions suspected of being neoplastic tumors via magnification colonoscopy with the indigo carmine dye spray method [26].
• Techniques for intraoperative localization of the stone bearing diverticulum included retrograde injection of indigo carmine, fluoroscopy and/or laparoscopic ultrasound [27].
• Endoscopic assessment was performed by cystoscopic inspection of stained urine flow from the orifices following the administration of intravenous dye (indigo carmine) or by retrograde ureteral catheterization [28].
• Impermeability of the laparoscopy sack after morcellation was also evaluated using indigo carmine stained normal saline placed in the used sack [29].
• Indigo carmine-induced severe hypotension in patients undergoing radical prostatectomy [30].

References