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Chemical Compound Review:

CHEMBL256368 (E)-pent-2-enal

Synonyms: CCRIS 3514, CCRIS 4564, AG-H-05011, CHEBI:61722, pent-2-enal, ...

Pan, J. et al., Smith, D. et al.

Smith, Spanĕl, Dabill, Cocker, Rajan,

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High impact information on gamma-Methylcrotonaldehyde

Our previous in vitro study demonstrated that PdG adducts of Acr, Cro, and Pen are predominantly derived from oxidation of omega-3 polyunsaturated fatty acids (PUFAs), whereas the long-chain Hep and HNE adducts are from omega-6 PUFAs [1].
The cyclic 1,N(2)-propanodeoxyguanosine (PdG) adducts are Michael addition products from reactions of deoxyguanosine (dG) with enals, including acrolein (Acr), crotonaldehyde (Cro), pentenal (Pen), heptenal (Hep), and 4-hydroxy-2-nonenal (HNE) [1].
Formaldehyde, acetaldehyde and pentenal, all known respiratory irritants associated with sensitisation to asthma of workers exposed to diesel exhaust, are variously present within the range 100-2000 ppb [2].

References

A solid-phase extraction/high-performance liquid chromatography-based (32)P-postlabeling method for detection of cyclic 1,N(2)-propanodeoxyguanosine adducts derived from enals. Pan, J., Davis, W., Trushin, N., Amin, S., Nath, R.G., Salem, N., Chung, F.L. Anal. Biochem. (2006) [Pubmed]
On-line analysis of diesel engine exhaust gases by selected ion flow tube mass spectrometry. Smith, D., Spanĕl, P., Dabill, D., Cocker, J., Rajan, B. Rapid Commun. Mass Spectrom. (2004) [Pubmed]

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