The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Vehicle Emissions

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Vehicle Emissions


High impact information on Vehicle Emissions


Chemical compound and disease context of Vehicle Emissions


Biological context of Vehicle Emissions


Anatomical context of Vehicle Emissions

  • Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element [19].
  • Moreover, rainfall may also contribute to the release of allergens from fungal spores and, along with the release of free allergen molecules from pollen grains, may be able to interact with other particles such as pollutants (i.e. diesel exhaust carbon particles) to trigger allergic asthma [20].
  • The results indicate that, over the range of concentrations tested, pathways for excretion of [14C]NP equivalents in urine and feces were independent of the exposure concentration of NP, whether in its pure form or associated with diesel exhaust particles [21].
  • This study demonstrates that exposure to diesel exhaust induces inflammatory response in healthy human airways, represented by an early increase in interleukin-6 and methylhistamine concentration and the percentage of neutrophils [22].
  • We have previously shown that intratracheal instillation of suspension of diesel exhaust particles enhances allergen-related eosinophilic airway inflammation, airway hyperresponsiveness, and local expression of interleukin (IL)-5 and granulocyte macrophage-colony stimulating factor (GM-CSF) in mice [23].

Associations of Vehicle Emissions with chemical compounds

  • 6-Nitrochrysene (6-NC) is a pollutant generated in diesel exhaust [24].
  • Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern [25].
  • It occurs in air as a product of the natural photooxidation of automobile exhaust, combustion processes, incinerators; formaldehyde has been found in municipal and industrial effluents and is present in food either naturally (fruits and vegetables, in the order of parts per million), or as a result of its use as a food additive [26].
  • Styrene is a component of cigarette smoke and automobile exhaust, and it may occur naturally at low levels in various types of foods [27].
  • OBJECTIVE: Because IL-4 organizes allergic responses in vivo, we have investigated whether pyrene, a major compound of diesel exhaust particles, can affect the production of IL-4 [28].

Gene context of Vehicle Emissions


Analytical, diagnostic and therapeutic context of Vehicle Emissions


  1. Enhancement of acute lung injury related to bacterial endotoxin by components of diesel exhaust particles. Yanagisawa, R., Takano, H., Inoue, K., Ichinose, T., Sadakane, K., Yoshino, S., Yamaki, K., Kumagai, Y., Uchiyama, K., Yoshikawa, T., Morita, M. Thorax (2003) [Pubmed]
  2. The masculinization of the fetus during pregnancy due to inhalation of diesel exhaust. Watanabe, N., Kurita, M. Environ. Health Perspect. (2001) [Pubmed]
  3. Alterations in the K-ras and p53 genes in rat lung tumors. Belinsky, S.A., Swafford, D.S., Finch, G.L., Mitchell, C.E., Kelly, G., Hahn, F.F., Anderson, M.W., Nikula, K.J. Environ. Health Perspect. (1997) [Pubmed]
  4. Mutagenicity of diesel-exhaust particle extract, 1-nitropyrene, and 2,7-dinitrofluorenone in Salmonella typhimurium under various metabolic activation conditions. Kohan, M., Claxton, L. Mutat. Res. (1983) [Pubmed]
  5. Effect of diesel exhaust particulate on bacillus Calmette-Guerin lung infection in mice and attendant changes in lung interstitial lymphoid subpopulations and IFNgamma response. Saxena, R.K., Saxena, Q.B., Weissman, D.N., Simpson, J.P., Bledsoe, T.A., Lewis, D.M. Toxicol. Sci. (2003) [Pubmed]
  6. Ubiquitous occurrence of 2-nitrofluoranthene and 2-nitropyrene in air. Ramdahl, T., Zielinska, B., Arey, J., Atkinson, R., Winer, A.M., Pitts, J.N. Nature (1986) [Pubmed]
  7. National vehicle emissions policies and practices and declining US carbon monoxide-related mortality. Mott, J.A., Wolfe, M.I., Alverson, C.J., Macdonald, S.C., Bailey, C.R., Ball, L.B., Moorman, J.E., Somers, J.H., Mannino, D.M., Redd, S.C. JAMA (2002) [Pubmed]
  8. 1,N2-propanodeoxyguanosine adducts: potential new biomarkers of smoking-induced DNA damage in human oral tissue. Nath, R.G., Ocando, J.E., Guttenplan, J.B., Chung, F.L. Cancer Res. (1998) [Pubmed]
  9. DNA adduct formation and T-lymphocyte mutation induction in F344 rats implanted with tumorigenic doses of 1,6-dinitropyrene. Smith, B.A., Fullerton, N.F., Heflich, R.H., Beland, F.A. Cancer Res. (1995) [Pubmed]
  10. Oxidative ability and toxicity of n-hexane insoluble fraction of diesel exhaust particles. Shima, H., Koike, E., Shinohara, R., Kobayashi, T. Toxicol. Sci. (2006) [Pubmed]
  11. Methemoglobinemia induced by automobile exhaust fumes. Suyama, H., Morikawa, S., Noma-Tanaka, S., Adachi, H., Kawano, Y., Kaneko, K., Ishihara, S. Journal of anesthesia. (2005) [Pubmed]
  12. Toxicity to rats of methanol-fueled engine exhaust inhaled continuously for 28 days. Maejima, K., Suzuki, T., Niwa, K., Numata, H., Maekawa, A., Nagase, S., Ishinishi, N. Journal of toxicology and environmental health. (1992) [Pubmed]
  13. Malignant lymphomas and leukemias, and exposures in the wood industry: an industry-based case-referent study. Partanen, T., Kauppinen, T., Luukkonen, R., Hakulinen, T., Pukkala, E. International archives of occupational and environmental health. (1993) [Pubmed]
  14. Diesel exhaust enhances allergic airway inflammation and hyperresponsiveness in mice. Miyabara, Y., Takano, H., Ichinose, T., Lim, H.B., Sagai, M. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  15. Generation of reactive oxygen species during interaction of diesel exhaust particle components with NADPH-cytochrome P450 reductase and involvement of the bioactivation in the DNA damage. Kumagai, Y., Arimoto, T., Shinyashiki, M., Shimojo, N., Nakai, Y., Yoshikawa, T., Sagai, M. Free Radic. Biol. Med. (1997) [Pubmed]
  16. 9,10-Phenanthraquinone in diesel exhaust particles downregulates Cu,Zn-SOD and HO-1 in human pulmonary epithelial cells: intracellular iron scavenger 1,10-phenanthroline affords protection against apoptosis. Sugimoto, R., Kumagai, Y., Nakai, Y., Ishii, T. Free Radic. Biol. Med. (2005) [Pubmed]
  17. Combined nasal challenge with diesel exhaust particles and allergen induces In vivo IgE isotype switching. Fujieda, S., Diaz-Sanchez, D., Saxon, A. Am. J. Respir. Cell Mol. Biol. (1998) [Pubmed]
  18. Lung cancer in a nonsmoking underground uranium miner. Mulloy, K.B., James, D.S., Mohs, K., Kornfeld, M. Environ. Health Perspect. (2001) [Pubmed]
  19. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. Li, N., Venkatesan, M.I., Miguel, A., Kaplan, R., Gujuluva, C., Alam, J., Nel, A. J. Immunol. (2000) [Pubmed]
  20. Concentrations of major grass group 5 allergens in pollen grains and atmospheric particles: implications for hay fever and allergic asthma sufferers sensitized to grass pollen allergens. Schäppi, G.F., Taylor, P.E., Pain, M.C., Cameron, P.A., Dent, A.W., Staff, I.A., Suphioglu, C. Clin. Exp. Allergy (1999) [Pubmed]
  21. Deposition, metabolism, and excretion of 1-[14C]nitropyrene and 1-[14C]nitropyrene coated on diesel exhaust particles as influenced by exposure concentration. Bond, J.A., Sun, J.D., Medinsky, M.A., Jones, R.K., Yeh, H.C. Toxicol. Appl. Pharmacol. (1986) [Pubmed]
  22. Airway inflammation following exposure to diesel exhaust: a study of time kinetics using induced sputum. Nordenhäll, C., Pourazar, J., Blomberg, A., Levin, J.O., Sandström, T., Adelroth, E. Eur. Respir. J. (2000) [Pubmed]
  23. Inhalation of diesel exhaust enhances allergen-related eosinophil recruitment and airway hyperresponsiveness in mice. Takano, H., Ichinose, T., Miyabara, Y., Shibuya, T., Lim, H.B., Yoshikawa, T., Sagai, M. Toxicol. Appl. Pharmacol. (1998) [Pubmed]
  24. Induction of mammary cancer by 6-nitrochrysene in female CD rats. el-Bayoumy, K., Rivenson, A., Upadhyaya, P., Chae, Y.H., Hecht, S.S. Cancer Res. (1993) [Pubmed]
  25. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. Diaz-Sanchez, D., Tsien, A., Fleming, J., Saxon, A. J. Immunol. (1997) [Pubmed]
  26. Oral toxicity of formaldehyde and its derivatives. Restani, P., Galli, C.L. Crit. Rev. Toxicol. (1991) [Pubmed]
  27. Styrene production, use, and human exposure. Miller, R.R., Newhook, R., Poole, A. Crit. Rev. Toxicol. (1994) [Pubmed]
  28. The environmental pollutant pyrene induces the production of IL-4. Bömmel, H., Li-Weber, M., Serfling, E., Duschl, A. J. Allergy Clin. Immunol. (2000) [Pubmed]
  29. Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways. Salvi, S.S., Nordenhall, C., Blomberg, A., Rudell, B., Pourazar, J., Kelly, F.J., Wilson, S., Sandström, T., Holgate, S.T., Frew, A.J. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  30. Synergistic effect of diesel organic extracts and allergen Der p 1 on the release of chemokines by peripheral blood mononuclear cells from allergic subjects: involvement of the map kinase pathway. Fahy, O., Hammad, H., Sénéchal, S., Pestel, J., Tonnel, A.B., Wallaert, B., Tsicopoulos, A. Am. J. Respir. Cell Mol. Biol. (2000) [Pubmed]
  31. The influence of diesel exhaust particles on mononuclear phagocytic cell-derived cytokines: IL-10, TGF-beta and IL-1 beta. Pacheco, K.A., Tarkowski, M., Sterritt, C., Negri, J., Rosenwasser, L.J., Borish, L. Clin. Exp. Immunol. (2001) [Pubmed]
  32. In vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines rantes, MIP-1alpha, and MCP-3 in humans. Diaz-Sanchez, D., Jyrala, M., Ng, D., Nel, A., Saxon, A. Clin. Immunol. (2000) [Pubmed]
  33. Components of diesel exhaust particles differentially affect lung expression of cyclooxygenase-2 related to bacterial endotoxin. Inoue, K., Takano, H., Yanagisawa, R., Ichinose, T., Sadakane, K., Yoshino, S., Yamaki, K., Uchiyama, K., Yoshikawa, T. Journal of applied toxicology : JAT. (2004) [Pubmed]
  34. Secretion of proinflammatory eicosanoid-like substances precedes allergen release from pollen grains in the initiation of allergic sensitization. Behrendt, H., Kasche, A., Ebner von Eschenbach, C., Risse, U., Huss-Marp, J., Ring, J. Int. Arch. Allergy Immunol. (2001) [Pubmed]
  35. Isolation, identification and bacterial mutagenicity of 2-nitro-9-fluorenone from diesel-exhaust particle extracts. Bechtold, W.E., Henderson, T.R., Brooks, A.L. Mutat. Res. (1986) [Pubmed]
  36. Induction of systemic Th1 and Th2 immune responses by oral administration of soluble antigen and diesel exhaust particles. Yoshino, S., Sagai, M. Cell. Immunol. (1999) [Pubmed]
  37. Lung cancer mortality and diesel exhaust: reanalysis of a retrospective cohort study of U.S. railroad workers. Crump, K.S. Inhalation toxicology. (1999) [Pubmed]
  38. Identification, by cDNA microarray, of A-raf and proliferating cell nuclear antigen as genes induced in rat lung by exposure to diesel exhaust. Sato, H., Sagai, M., Suzuki, K.T., Aoki, Y. Res. Commun. Mol. Pathol. Pharmacol. (1999) [Pubmed]
WikiGenes - Universities