High impact information on Sulforaphane nitrile

• Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells [1].
• The results show a functional induction of glucuronidation by sulforaphane but not sulforaphane nitrile, and show that the pathway of metabolism of glucosinolates in Brassica vegetables is important in determining the resulting biological and anticarcinogenic activities [1].
• However, a number of studies have demonstrated that sulforaphane yield from glucoraphanin is low, and that a non-bioactive nitrile analog, sulforaphane nitrile, is the primary hydrolysis product when plant tissue is crushed at room temperature [2].
• A significant loss of ESP activity paralleled the decrease in sulforaphane nitrile formation [2].

Analytical, diagnostic and therapeutic context of Sulforaphane nitrile

• Refractive index was used to detect sulforaphane nitrile, and absorbance at 254 nm was used to detect sulforaphane [3].
• Preparative HPLC method for the purification of sulforaphane and sulforaphane nitrile from Brassica oleracea [3].

References