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Gene Review

ESP  -  epithiospecifier protein

Arabidopsis thaliana

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Disease relevance of ESP

  • A 43 kDa protein with ESP activity and sequence homology to the ESP of Arabidopsis thaliana was cloned from the broccoli cv. Packman and expressed in Escherichia coli [1].
  • In no-choice experiments, where larvae were confined on one or the other ecotype, weight gain was more rapid on Landsberg erecta than on Columbia. Genetic mapping of this difference in insect susceptibility using recombinant inbred lines resulted in the discovery of the TASTY locus near 85 cM on chromosome 1 of Arabidopsis [2].

High impact information on ESP


Biological context of ESP

  • This observation suggests that ESP is likely to be involved in jasmonate-mediated defence and disease resistance mechanisms [5].
  • 3. The amino acid sequence of several tryptic peptides of ESP (accounting for about 50% of the total sequence) made it possible to establish the high similarity (81% identity) with a hypothetical 37 kDa protein (TrEMBL data base accession number Q39104) and several jasmonate-inducible proteins from Arabidopsis thaliana [5].

Associations of ESP with chemical compounds


Other interactions of ESP


Analytical, diagnostic and therapeutic context of ESP


  1. Epithiospecifier protein from broccoli (Brassica oleracea L. ssp. italica) inhibits formation of the anticancer agent sulforaphane. Matusheski, N.V., Swarup, R., Juvik, J.A., Mithen, R., Bennett, M., Jeffery, E.H. J. Agric. Food Chem. (2006) [Pubmed]
  2. The TASTY locus on chromosome 1 of Arabidopsis affects feeding of the insect herbivore Trichoplusia ni. Jander, G., Cui, J., Nhan, B., Pierce, N.E., Ausubel, F.M. Plant Physiol. (2001) [Pubmed]
  3. The gene controlling the quantitative trait locus EPITHIOSPECIFIER MODIFIER1 alters glucosinolate hydrolysis and insect resistance in Arabidopsis. Zhang, Z., Ober, J.A., Kliebenstein, D.J. Plant Cell (2006) [Pubmed]
  4. The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and influences Trichoplusia ni herbivory. Lambrix, V., Reichelt, M., Mitchell-Olds, T., Kliebenstein, D.J., Gershenzon, J. Plant Cell (2001) [Pubmed]
  5. Isolation of the epithiospecifier protein from oil-rape (Brassica napus ssp. oleifera) seed and its characterization. Bernardi, R., Negri, A., Ronchi, S., Palmieri, S. FEBS Lett. (2000) [Pubmed]
  6. Characterisation of recombinant epithiospecifier protein and its over-expression in Arabidopsis thaliana. Zabala, M.d.e. .T., Grant, M., Bones, A.M., Bennett, R., Lim, Y.S., Kissen, R., Rossiter, J.T. Phytochemistry (2005) [Pubmed]
  7. Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli. Matusheski, N.V., Juvik, J.A., Jeffery, E.H. Phytochemistry (2004) [Pubmed]
  8. Microarray and differential display identify genes involved in jasmonate-dependent anther development. Mandaokar, A., Kumar, V.D., Amway, M., Browse, J. Plant Mol. Biol. (2003) [Pubmed]
  9. The antagonist function of Arabidopsis WRKY53 and ESR/ESP in leaf senescence is modulated by the jasmonic and salicylic acid equilibrium. Miao, Y., Zentgraf, U. Plant. Cell (2007) [Pubmed]
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