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Chemical Compound Review:

Pseudocyanine (2Z)-1-ethyl-2-[(1- ethylquinolin-2...

Synonyms: Decynium 22, 20766-49-8, Pseudoisocyanine, 977-96-8 (iodide), 1613-31-6 (bromide), ...

Hayer, M. et al., Pasternack, R.F. et al., Brito de Barros, R. et al., Bleasby, K. et al., González, C.B. et al., et al.

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High impact information on Pseudocyanine

The kinetics of J-aggregate formation has been studied for two chromophores, tetrakis-4-sulfonatophenylporphine in an acid medium and pseudoisocyanine on a polyvinylsulfonate template [1].
Decynium-22 inhibited hOCT3 with 10 fold higher potency than hOCT1 and hOCT2 [2].
In contrast, secretion of MPP+ was unaffected by addition of either TEA (2 mM) or decynium-22 (2 microM) to either apical or basolateral membranes [3].
Cytochemical study of pseudoisocyanine stained human chromosomes [4].
When stably expressed in human embryonic kidney (HEK293) cells, only the full length hOCT1 cDNA mediated decynium-22 (D22)-sensitive uptake of tritiated 1-methyl-4-phenylpyridinium ([3H]-MPP+) [5].

Associations of Pseudocyanine with other chemical compounds

Films of pseudoisocyanine iodide in a cellulose acetate matrix were prepared by spin coating and characterized by UV/Vis absorption and fluorescence spectroscopies [6].

Analytical, diagnostic and therapeutic context of Pseudocyanine

Pseudoisocyanine was applied to sections previously used for immunocytochemistry [7].

References

Aggregation kinetics of extended porphyrin and cyanine dye assemblies. Pasternack, R.F., Fleming, C., Herring, S., Collings, P.J., dePaula, J., DeCastro, G., Gibbs, E.J. Biophys. J. (2000) [Pubmed]
Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Hayer-Zillgen, M., Brüss, M., Bönisch, H. Br. J. Pharmacol. (2002) [Pubmed]
Characterization of MPP+ secretion across human intestinal Caco-2 cell monolayers: role of P-glycoprotein and a novel Na(+)-dependent organic cation transport mechanism. Bleasby, K., Chauhan, S., Brown, C.D. Br. J. Pharmacol. (2000) [Pubmed]
Cytochemical study of pseudoisocyanine stained human chromosomes. Vagner-Capodano, A.M., Pinna-Delgrossi, M.H., Stahl, A. Hum. Genet. (1976) [Pubmed]
Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1). Hayer, M., Bönisch, H., Brüss, M. Ann. Hum. Genet. (1999) [Pubmed]
The role of cellulose acetate as a matrix for aggregation of pseudoisocyanine iodide: absorption and emission studies. Brito de Barros, R., Ilharco, L.M. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2001) [Pubmed]
Ultrastructure and immunocytochemistry of neurons in the supraoptic and paraventricular nuclei of the lizard Liolaemus cyanogaster. Evidence for the intracisternal location of the precursor of neurophysin. González, C.B., Rodríguez, E.M. Cell Tissue Res. (1980) [Pubmed]

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