The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Cyperquat     1-methyl-4-phenyl-pyridine

Synonyms: MPP+, CHEBI:641, SureCN37321, CHEMBL311617, CCRIS 2187, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Cyperquat


Psychiatry related information on Cyperquat


High impact information on Cyperquat


Chemical compound and disease context of Cyperquat


Biological context of Cyperquat


Anatomical context of Cyperquat


Associations of Cyperquat with other chemical compounds


Gene context of Cyperquat


Analytical, diagnostic and therapeutic context of Cyperquat


  1. Defective Fas expression exacerbates neurotoxicity in a model of Parkinson's disease. Landau, A.M., Luk, K.C., Jones, M.L., Siegrist-Johnstone, R., Young, Y.K., Kouassi, E., Rymar, V.V., Dagher, A., Sadikot, A.F., Desbarats, J. J. Exp. Med. (2005) [Pubmed]
  2. The neurotoxin 1-methyl-4-phenylpyridinium: a selective cytostatic agent in small-cell lung cancer cell lines with neuroendocrine properties. Marini, A.M., Fridman, R., Kanemoto, T., Martin, G.R., Guo, Y., Passaniti, A. J. Natl. Cancer Inst. (1992) [Pubmed]
  3. D-beta-hydroxybutyrate protects neurons in models of Alzheimer's and Parkinson's disease. Kashiwaya, Y., Takeshima, T., Mori, N., Nakashima, K., Clarke, K., Veech, R.L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. Homology of a vesicular amine transporter to a gene conferring resistance to 1-methyl-4-phenylpyridinium. Stern-Bach, Y., Keen, J.N., Bejerano, M., Steiner-Mordoch, S., Wallach, M., Findlay, J.B., Schuldiner, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells. Bollimuntha, S., Singh, B.B., Shavali, S., Sharma, S.K., Ebadi, M. J. Biol. Chem. (2005) [Pubmed]
  6. Behavioral and biochemical changes following acute administration of MPTP and MPP+. Tadano, T., Satoh, N., Sakuma, I., Matsumura, T., Kisara, K., Arai, Y., Kinemuchi, H. Life Sci. (1987) [Pubmed]
  7. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Du, Y., Ma, Z., Lin, S., Dodel, R.C., Gao, F., Bales, K.R., Triarhou, L.C., Chernet, E., Perry, K.W., Nelson, D.L., Luecke, S., Phebus, L.A., Bymaster, F.P., Paul, S.M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  8. Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Przedborski, S., Jackson-Lewis, V., Yokoyama, R., Shibata, T., Dawson, V.L., Dawson, T.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  9. Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Frim, D.M., Uhler, T.A., Galpern, W.R., Beal, M.F., Breakefield, X.O., Isacson, O. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  10. Structural dependence of the inhibition of mitochondrial respiration and of NADH oxidase by 1-methyl-4-phenylpyridinium (MPP+) analogs and their energized accumulation by mitochondria. Ramsay, R.R., Youngster, S.K., Nicklas, W.J., McKeown, K.A., Jin, Y.Z., Heikkila, R.E., Singer, T.P. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  11. Nitric oxide donors protect cultured rat astrocytes from 1-methyl-4-phenylpyridinium-induced toxicity. Tsai, M.J., Lee, E.H. Free Radic. Biol. Med. (1998) [Pubmed]
  12. A dopaminergic cell line variant resistant to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Denton, T., Howard, B.D. J. Neurochem. (1987) [Pubmed]
  13. Brain-derived neurotrophic factor protects dopamine neurons against 6-hydroxydopamine and N-methyl-4-phenylpyridinium ion toxicity: involvement of the glutathione system. Spina, M.B., Squinto, S.P., Miller, J., Lindsay, R.M., Hyman, C. J. Neurochem. (1992) [Pubmed]
  14. Evaluation of the protective effect of oestradiol against toxicity induced by 6-hydroxydopamine and 1-methyl-4-phenylpyridinium ion (Mpp+) towards dopaminergic mesencephalic neurones in primary culture. Callier, S., Le Saux, M., Lhiaubet, A.M., Di Paolo, T., Rostène, W., Pelaprat, D. J. Neurochem. (2002) [Pubmed]
  15. The role of glutathione in dopaminergic neuronal survival. Nakamura, K., Wang, W., Kang, U.J. J. Neurochem. (1997) [Pubmed]
  16. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Zhu, J.H., Horbinski, C., Guo, F., Watkins, S., Uchiyama, Y., Chu, C.T. Am. J. Pathol. (2007) [Pubmed]
  17. Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons. Holtz, W.A., O'Malley, K.L. J. Biol. Chem. (2003) [Pubmed]
  18. The p53-activated gene, PAG608, requires a zinc finger domain for nuclear localization and oxidative stress-induced apoptosis. Higashi, Y., Asanuma, M., Miyazaki, I., Haque, M.E., Fujita, N., Tanaka, K., Ogawa, N. J. Biol. Chem. (2002) [Pubmed]
  19. 6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation. Alves da Costa, C., Dunys, J., Brau, F., Wilk, S., Cappai, R., Checler, F. J. Biol. Chem. (2006) [Pubmed]
  20. Proteasome-dependent degradation of cyclin D1 in 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell cycle arrest. Bai, J., Nakamura, H., Ueda, S., Kwon, Y.W., Tanaka, T., Ban, S., Yodoi, J. J. Biol. Chem. (2004) [Pubmed]
  21. Subcellular compartmentalization of 1-methyl-4-phenylpyridinium with catecholamines in adrenal medullary chromaffin vesicles may explain the lack of toxicity to adrenal chromaffin cells. Reinhard, J.F., Diliberto, E.J., Viveros, O.H., Daniels, A.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  22. IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity. Jiang, W., Prokopenko, O., Wong, L., Inouye, M., Mirochnitchenko, O. Mol. Cell. Biol. (2005) [Pubmed]
  23. Energy-driven uptake of the neurotoxin 1-methyl-4-phenylpyridinium into chromaffin granules via the catecholamine transporter. Daniels, A.J., Reinhard, J.F. J. Biol. Chem. (1988) [Pubmed]
  24. Identification and characterization of a novel monoamine transporter in the human brain. Engel, K., Zhou, M., Wang, J. J. Biol. Chem. (2004) [Pubmed]
  25. Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions. Sawada, H., Kohno, R., Kihara, T., Izumi, Y., Sakka, N., Ibi, M., Nakanishi, M., Nakamizo, T., Yamakawa, K., Shibasaki, H., Yamamoto, N., Akaike, A., Inden, M., Kitamura, Y., Taniguchi, T., Shimohama, S. J. Biol. Chem. (2004) [Pubmed]
  26. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. Yang, L., Matthews, R.T., Schulz, J.B., Klockgether, T., Liao, A.W., Martinou, J.C., Penney, J.B., Hyman, B.T., Beal, M.F. J. Neurosci. (1998) [Pubmed]
  27. Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos. Son, J.H., Chun, H.S., Joh, T.H., Cho, S., Conti, B., Lee, J.W. J. Neurosci. (1999) [Pubmed]
  28. cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney. Urakami, Y., Akazawa, M., Saito, H., Okuda, M., Inui, K. J. Am. Soc. Nephrol. (2002) [Pubmed]
  29. Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. Masuda, S., Terada, T., Yonezawa, A., Tanihara, Y., Kishimoto, K., Katsura, T., Ogawa, O., Inui, K. J. Am. Soc. Nephrol. (2006) [Pubmed]
  30. Local striatal infusion of MPP+ does not result in increased hydroxylation after systemic administration of 4-hydroxybenzoate. Ste-Marie, L., Vachon, L., Bémeur, C., Lambert, J., Montgomery, J. Free Radic. Biol. Med. (1999) [Pubmed]
  31. Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. Wu, X., Kekuda, R., Huang, W., Fei, Y.J., Leibach, F.H., Chen, J., Conway, S.J., Ganapathy, V. J. Biol. Chem. (1998) [Pubmed]
  32. Akt1/PKBalpha protects PC12 cells against the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium and reduces the levels of oxygen-free radicals. Salinas, M., Martín, D., Alvarez, A., Cuadrado, A. Mol. Cell. Neurosci. (2001) [Pubmed]
  33. Interaction among mitochondria, mitogen-activated protein kinases, and nuclear factor-kappaB in cellular models of Parkinson's disease. Cassarino, D.S., Halvorsen, E.M., Swerdlow, R.H., Abramova, N.N., Parker, W.D., Sturgill, T.W., Bennett, J.P. J. Neurochem. (2000) [Pubmed]
  34. Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells. Chu, C.T., Zhu, J.H., Cao, G., Signore, A., Wang, S., Chen, J. J. Neurochem. (2005) [Pubmed]
  35. The role of tissue transglutaminase in 1-methyl-4-phenylpyridinium (MPP+)-induced toxicity in differentiated human SH-SY5Y neuroblastoma cells. Beck, K.E., De Girolamo, L.A., Griffin, M., Billett, E.E. Neurosci. Lett. (2006) [Pubmed]
  36. 1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis. Leist, M., Volbracht, C., Fava, E., Nicotera, P. Mol. Pharmacol. (1998) [Pubmed]
  37. Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode. Davey, G.P., Tipton, K.F., Murphy, M.P. Biochem. J. (1992) [Pubmed]
  38. Toxicity of 1-methyl-4-phenylpyridinium for rat dopaminergic neurons in culture: selectivity and irreversibility. Michel, P.P., Dandapani, B.K., Knusel, B., Sanchez-Ramos, J., Hefti, F. J. Neurochem. (1990) [Pubmed]
  39. Immortalized dopamine neurons: A model to study neurotoxicity and neuroprotection. Clarkson, E.D., Edwards-Prasad, J., Freed, C.R., Prasad, K.N. Proc. Soc. Exp. Biol. Med. (1999) [Pubmed]
  40. Studies on 4-benzyl-1-methyl-1,2,3,6-tetrahydropyridine, a nonneurotoxic analogue of the parkinsonian inducing agent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Naiman, N., Rollema, H., Johnson, E., Castagnoli, N. Chem. Res. Toxicol. (1990) [Pubmed]
WikiGenes - Universities