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Chemical Compound Review:

AC1L1HIO (1-methyl-3,4,5,6-tetrahydro- 2H-pyridin-3...

Synonyms: LS-11364, LS-11365, PM 170, EINECS 279-575-7, Acetic acid, (4-chlorophenoxy)-, (2S-cis)-

This record was replaced with 54673.

Massicot, F. et al., Massicot, F. et al.

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Disease relevance of 2-(4-chlorophenoxy)acetic acid (1-methyl-3-piperidyl)methyl ester

The body weight and body fat were significantly increased by GTG injection and these increases in the GTG-obese group were reduced by PM 170 [1].

High impact information on 2-(4-chlorophenoxy)acetic acid (1-methyl-3-piperidyl)methyl ester

Activation of energy expenditure in the rat by a new non-amphetaminic compound: the (4-chlorophenoxyacetate) N-methyl 3-hydroxymethyl piperidine, hydrochloride (PM 170) [2].
After an acute treatment PM 170 increases energy expenditure by increasing resting oxygen consumption (VO2) and in the doses used, produced dose-related increases in VO2 [2].

References

Effects of a new anorectic drug (PM 170) on development of gold thioglucose-induced obesity in mice. Massicot, F., Falcou, R., Heymans, F., Godfroid, J.J., Apfelbaum, M. Gen. Pharmacol. (1987) [Pubmed]
Activation of energy expenditure in the rat by a new non-amphetaminic compound: the (4-chlorophenoxyacetate) N-methyl 3-hydroxymethyl piperidine, hydrochloride (PM 170). Massicot, F., Ricquier, D., Godfroid, J.J., Apfelbaum, M. International journal of obesity. (1985) [Pubmed]

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