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Chemical Compound Review:

Tomatotone 2-(4-chlorophenoxy)ethanoic acid

Synonyms: Sure-Set, FRUITONE(R), Tomato Fix, PubChem20127, PS39_SUPELCO, ...

Lundgren, B. et al., Itoh, K. et al., Mészáros, J. et al., Streber, W.R. et al.

Itoh, Tashiro, Uobe, Kamagata, Suyama, Yamamoto,

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Disease relevance of Tomato hold

Although all root nodule Bradyrhizobium strains were unable to degrade 2,4-D, three strains carrying cadA homologs degraded 4-chlorophenoxyacetate with the accumulation of 4-chlorophenol as an intermediate, suggesting the involvement of cadA homologs in the cleavage of the aryl ether linkage [1].
Pseudomonas sp. strain B13, containing the cloned tfdA, was able to degrade phenoxyacetic acid and 4-chlorophenoxyacetic acid [2].

Psychiatry related information on Tomato hold

The effects of three-day treatment with meclophenoxate (Centrophenoxin) and its components, p-chlorophenoxyacetic acid and dimethylaminoethanol, on the aggressiveness and pain threshold in mice were investigated. p-Chlorophenoxyacetic acid increased the aggressiveness and pain sensitivity [3].

High impact information on Tomato hold

The effects of dietary exposure to 0.125% (w/w) p-chlorophenoxyacetic acid, 2,4-dichlorophenoxyacetic acid or 2,4,5-trichlorophenoxyacetic acid on the content of peroxisomes and levels of certain xenobiotic-metabolizing enzymes in mouse liver have been investigated [4].
Induction of cytosolic and microsomal epoxide hydrolases and proliferation of peroxisomes and mitochondria in mouse liver after dietary exposure to p-chlorophenoxyacetic acid, 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid [4].

References

Root nodule Bradyrhizobium spp. harbor tfdAalpha and cadA, homologous with genes encoding 2,4-dichlorophenoxyacetic acid-degrading proteins. Itoh, K., Tashiro, Y., Uobe, K., Kamagata, Y., Suyama, K., Yamamoto, H. Appl. Environ. Microbiol. (2004) [Pubmed]
Analysis, cloning, and high-level expression of 2,4-dichlorophenoxyacetate monooxygenase gene tfdA of Alcaligenes eutrophus JMP134. Streber, W.R., Timmis, K.N., Zenk, M.H. J. Bacteriol. (1987) [Pubmed]
Further study on pharmacology of meclophenoxate and it components in mice. Mészáros, J., Gajewska, S. Polish journal of pharmacology and pharmacy. (1976) [Pubmed]
Induction of cytosolic and microsomal epoxide hydrolases and proliferation of peroxisomes and mitochondria in mouse liver after dietary exposure to p-chlorophenoxyacetic acid, 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid. Lundgren, B., Meijer, J., DePierre, J.W. Biochem. Pharmacol. (1987) [Pubmed]

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