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Chemical Compound Review

Claforan     (6R,7S)-3-(acetyloxymethyl)- 7-[[(2E)-2-(2...

Synonyms: Cefotaxim, cefotaxime, Cephotaxime, CHEMBL102, AC1NUIF8, ...
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Disease relevance of cefotaxime


High impact information on cefotaxime

  • Strains with substitutions within a conserved amino acid motif changing STMK to SAFK and a Leu-to-Val change just before the KSG motif were highly resistant to CTX (MIC, >==2 microgram/ml) [3].
  • The dCTX compound was classified as a drug with a potency superior to a "second-generation" cephalosporin and possessed greater beta-lactamase stability against some enzymes compared to CTX [1].


  1. A review of cephalosporin metabolism: a lesson to be learned for future chemotherapy. Jones, R.N. Diagn. Microbiol. Infect. Dis. (1989) [Pubmed]
  2. In vitro antibacterial activity and beta-lactamase stability of cefodizime, a new cephalosporin antibiotic. Kasai, K., Tsuji, A., Miyazaki, S., Goto, S., Fujimoto, K., Masuyoshi, S., Arai, S. The Japanese journal of antibiotics. (1984) [Pubmed]
  3. Diversity of substitutions within or adjacent to conserved amino acid motifs of penicillin-binding protein 2X in cephalosporin-resistant Streptococcus pneumoniae isolates. Asahi, Y., Takeuchi, Y., Ubukata, K. Antimicrob. Agents Chemother. (1999) [Pubmed]
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