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Chemical Compound Review:

AC1NUOU4 (1Z)-1- (diaminomethylidenehydrazinyli dene)...

Synonyms: SureCN5256658

Singh, R. et al., Dorhout, B. et al., Dorhout, B. et al., Dorhout, B. et al., Seiler, N. et al., et al.

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Disease relevance of Sardomozide

In vivo growth inhibition of L1210 leukemia by 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), a new inhibitor of S-adenosylmethionine decarboxylase [1].

High impact information on Sardomozide

We observed that both SAM-486A and DFMO, either alone or in combination, inhibited cell proliferation, induced p21 and arrested cells in the G(0)-G(1) phase of the cell cycle but failed to activate caspase-3 as assessed by enzymatic assay of caspase-3, western blot analysis of the proteolytic cleavage of caspase-3 protein as well as TUNEL assay [2].
Furthermore, pre-incubation of the cells with SAM-486A and DFMO for 4 days, either alone or in combination significantly inhibited the activation of caspase-3 and apoptosis by NOHA when compared with that observed with cells treated with NOHA alone [2].
4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664), on polyamine metabolism in the mouse leukaemia cell line L1210 [3].
We studied the in vivo effects of 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), alpha-difluoromethylornithine (DFMO) and a combination of CGP 48664A-DFMO on tumor growth, cell-cycle phase distribution and polyamine contents [4].
We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A) [1].

Associations of Sardomozide with other chemical compounds

In vivo manipulation of L1210 cell cycle phase distribution with alpha-difluoromethylornithine, 4-amidinoindan-1-one 2'-amidinohydrazone and N1-acetylspermine [5].
CGP 48664A (2-(4-aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene dihydrochloride, CAS 149400-88-4) is a new potent inhibitor of S-adenosylmethionine decarboxylase with antitumor properties [6].
The competitive S-adenosylmethionine decarboxylase (SAMdc; EC 4.1.1.50) inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A) inhibits growth more effectively than the irreversible SAMdc inhibitor 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine (AbeAdo), while having similar effects on polyamine contents [7].

Gene context of Sardomozide

4-Amidinoindan-1-one 2'-amidinohydrazone: a new potent and selective inhibitor of S-Adenosylmethionine decarboxylase [8].

References

In vivo growth inhibition of L1210 leukemia by 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), a new inhibitor of S-adenosylmethionine decarboxylase. Dorhout, B., Te Velde, R.J., Ferwerda, H., Kingma, A.W., De Hoog, E., Muskiet, F.A. Int. J. Cancer (1995) [Pubmed]
Activation of caspase-3 activity and apoptosis in MDA-MB-468 cells by N(omega)-hydroxy-L-arginine, an inhibitor of arginase, is not solely dependent on reduction in intracellular polyamines. Singh, R., Pervin, S., Wu, G., Chaudhuri, G. Carcinogenesis (2001) [Pubmed]
CGP 48664, a potent and specific S-adenosylmethionine decarboxylase inhibitor: effects on regulation and stability of the enzyme. Svensson, F., Mett, H., Persson, L. Biochem. J. (1997) [Pubmed]
In vivo effects of 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A) and alpha-difluoromethylornithine (DFMO) on L1210 growth, cell-cycle phase distribution and polyamine contents. Dorhout, B., te Velde, R.J., Ferwerda, H., Kingma, A.W., de Hoog, E., Muskiet, F.A. Int. J. Cancer (1995) [Pubmed]
In vivo manipulation of L1210 cell cycle phase distribution with alpha-difluoromethylornithine, 4-amidinoindan-1-one 2'-amidinohydrazone and N1-acetylspermine. Dorhout, B., Ferwerda, H., Kingma, A.W., de Hoog, E., Muskiet, F.A. Biochim. Biophys. Acta (1998) [Pubmed]
Observations with an S-adenosylmethionine decarboxylase inhibitor in rats with prostatic adenocarcinoma. Seiler, N., Delcros, J.G., Cipolla, B., Chamaillard, L., Havouis, R., Quemener, V., Moulinoux, J.P. Arzneimittel-Forschung. (1996) [Pubmed]
4-Amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A) exerts in vitro growth inhibitory effects that are not only related to S-adenosylmethionine decarboxylase (SAMdc) inhibition. Dorhout, B., Odink, M.F., de Hoog, E., Kingma, A.W., van der Veer, E., Muskiet, F.A. Biochim. Biophys. Acta (1997) [Pubmed]
4-Amidinoindan-1-one 2'-amidinohydrazone: a new potent and selective inhibitor of S-Adenosylmethionine decarboxylase. Stanek, J., Caravatti, G., Frei, J., Furet, P., Mett, H., Schneider, P., Regenass, U. J. Med. Chem. (1993) [Pubmed]

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