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Chemical Compound Review:

AC1NUQM6 sodium(6R,7S)-7-[[(2Z)-2-(2- amino-1,3...

Synonyms:

This record was replaced with 6336466.

Angehrn, P. et al., Hoogkamer, J.F. et al., Pfaller, M.A. et al., Wüst, J. et al.

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Disease relevance of (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-(azidomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Ro 40-6890 was active against members of the family Enterobacteriaceae, Moraxella catarrhalis, pneumococci, other Streptococcus spp., and methicillin-susceptible staphylococci [1].
Ro 41-3399 is a novel orally active ester of Ro 40-6890, an aminothiazolyl cephalosporin with potent in vitro activities against commonly encountered aerobic gram-positive bacteria (streptococci and methicillin-susceptible staphylococci) and gram-negative bacteria (members of the family Enterobacteriaceae, haemophili, meningococci, and gonococci) [2].
Prevotella, Porphyromonas, Peptostreptococcus, Fusobacterium and Clostridium spp. were susceptible to Ro 40-6890, with few exceptions [3].

Psychiatry related information on (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-(azidomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Pharmacodynamic activity of a cephalosporin, Ro 40-6890, in human skin blister fluid: antibiotic activity in concert with host defense mechanisms [4].

High impact information on (6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-(azidomethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Ro 40-6890 distributed well from plasma into CBF [4].
Ro 40-6890 showed a high affinity for the essential penicillin-binding proteins of susceptible bacteria and was resistant to hydrolysis by a broad array of beta-lactamases [2].

References

Antimicrobial activity and disk diffusion susceptibility testing of Ro 40-6890, the active metabolite of the new cephalosporin ester, Ro 41-3399. Pfaller, M.A., Barry, A.L., Fuchs, P.C. Antimicrob. Agents Chemother. (1993) [Pubmed]
Antibacterial properties of Ro 40-6890, a broad-spectrum cephalosporin, and its novel orally absorbable ester, Ro 41-3399. Angehrn, P., Hohl, P., Hubschwerlen, C., Page, M., Then, R. Antimicrob. Agents Chemother. (1992) [Pubmed]
Comparative in vitro activity of Ro 40-6890, Ro 41-3399, and other antimicrobial agents against anaerobic bacteria. Wüst, J., Hardegger, U. Eur. J. Clin. Microbiol. Infect. Dis. (1992) [Pubmed]
Pharmacodynamic activity of a cephalosporin, Ro 40-6890, in human skin blister fluid: antibiotic activity in concert with host defense mechanisms. Hoogkamer, J.F., Hesse, W.H., Sansano, S., Zimmerli, W. Antimicrob. Agents Chemother. (1993) [Pubmed]

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