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Chemical Compound Review:

Iobenguane 2-[(3- iodophenyl)methyl]guanidine

Synonyms: MIBG, CHEMBL818, Lopac-I-9890, AGN-PC-00DVB3, SureCN140591, ...

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Disease relevance of Iobenguane

To our knowledge pheochromocytoma was always diagnosed by increased urinary catecholamine, computerized tomography, magnetic resonance imaging and 131iodine iobenguane scintigraphy [1].
Secondly, Parkinson's disease is a cause of primary autonomic failure with an involvement of the peripheral autonomic system as shown by the ubiquitous distribution of Lewy bodies and reduced iobenguane [metaiodobenzylguanidine (MIBG)] cardiac uptake [2].
131I iobenguane scanning is useful in locating extra-adrenal disease and may have a role in the treatment of metastases [3].

High impact information on Iobenguane

Techniques include ultrasonography, barium studies, endoscopy, computed tomography, magnetic resonance imaging, somatostatin receptor scintigraphy, iobenguane scintigraphy, and, in select cases, positron emission tomography [4].

References

Experience with retroperitoneal laparoscopic adrenalectomy for pheochromocytoma. Salomon, L., Rabii, R., Soulie, M., Mouly, P., Hoznek, A., Cicco, A., Saint, F., Alame, W., Antiphon, P., Chopin, D., Plante, P., Abbou, C.C. J. Urol. (2001) [Pubmed]
Orthostatic hypotension in patients with Parkinson's disease: pathophysiology and management. Senard, J.M., Brefel-Courbon, C., Rascol, O., Montastruc, J.L. Drugs & aging. (2001) [Pubmed]
Recent advances in the surgical management of pheochromocytoma. Hoover, E.L., Weaver, W.L. Journal of the National Medical Association. (1989) [Pubmed]
Anatomic and functional imaging of metastatic carcinoid tumors. Scarsbrook, A.F., Ganeshan, A., Statham, J., Thakker, R.V., Weaver, A., Talbot, D., Boardman, P., Bradley, K.M., Gleeson, F.V., Phillips, R.R. Radiographics : a review publication of the Radiological Society of North America, Inc (2007) [Pubmed]

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