Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

AG-G-13673 nitromethanamine

Synonyms: AC1L1UML, CTK2B0925, AKOS006360142, 62885-54-5, Methanamine, 1-nitro-, ...

Hassel, M. et al., Frei, E. et al., Frei, E. et al., Hassel, M. et al., Frei, E. et al., et al.

Frei, Gilberg, Schröder, Breuer, Edler, Wiessler,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on nitromethanamine

It can be demethylated to N-nitromethylamine and formaldehyde and reduced to N-nitroso-dimethylamine (NDMA): a potent liver carcinogen and also of the nasal cavity if activation in the liver is blocked [1].
Pharmacokinetics of N-nitrodimethylamine and N-nitromethylamine in the rat [2].
N-Nitrodimethylamine was cleared rapidly from rat blood, while N-nitromethylamine was rapidly distributed into body water but had a long elimination half-life [2].
N- Nitromethylamine was not mutagenic with or without the metabolic activation system [3].
All four compounds and N-nitromethylamine were tested for their ability to induce DNA single strand breaks in hepatocytes and in SV 40-transformed Chinese hamster embryo cell lines [4].

Biological context of nitromethanamine

N-Nitromethylamine is also carcinogenic and was reduced by liver cytoplasm to a protein binding species (methyldiazohydroxide?) [5].

Anatomical context of nitromethanamine

N-Nitromethylamine (NTMA), a product of the oxidative metabolism of NTDMA, was also carcinogenic, leading to neurogenic tumours of the lumbar region of the spine [6].

References

Analysis of the inhibition of N-nitroso-dimethylamine activation in the liver by N-nitro-dimethylamine using a new non-linear statistical method. Frei, E., Gilberg, F., Schröder, M., Breuer, A., Edler, L., Wiessler, M. Carcinogenesis (1999) [Pubmed]
Pharmacokinetics of N-nitrodimethylamine and N-nitromethylamine in the rat. Hassel, M., Frei, E., Streeter, A.J., Wiessler, M. Carcinogenesis (1990) [Pubmed]
Formaldehyde as a possible mutagenic metabolite of N-nitrodimethylamine and of other agents which are suggested to yield non-alkylating species in vitro. Pool, B.L., Frei, E., Plesch, W.J., Romruen, K., Wiessler, M. Carcinogenesis (1984) [Pubmed]
Determination of DNA single strand breaks and selective DNA amplification by N-nitrodimethylamine and analogs, and estimation of the indicator cells' metabolic capacities. Frei, E., Pool, B.L., Glatt, H.R., Gemperlein-Mertes, I., Oesch, F., Schlehofer, J.R., Schmezer, P., Weber, H., Wiessler, M. J. Cancer Res. Clin. Oncol. (1986) [Pubmed]
Subcellular fractions of rat organs contain nitroreductases which reduce N-nitrodimethylamine to N-nitrosodimethylamine. Frei, E., Hassel, M., Spiegelhalder, B., Wiessler, M. IARC Sci. Publ. (1991) [Pubmed]
Investigation into the pharmacodynamics of the carcinogen N-nitrodimethylamine. Hassel, M., Frei, E., Scherf, H.R., Wiessler, M. IARC Sci. Publ. (1987) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.