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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Lumbosacral Region

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Disease relevance of Lumbosacral Region


High impact information on Lumbosacral Region

  • A comparison of the distribution of these peptides reveals an exceptional pattern for VIP, with relatively much higher levels in the lumbosacral region [6].
  • Skeletal analysis revealed homeotic transformations corresponding to anteriorisations of vertebrae #21 to #25 (L1 to L5) in the lumbar region of Hoxa-9-/- mutants; vertebrae #23 to #25 (L3 to L5) in the lumbar region together with vertebrae #28, #30 and #31 (S2, S4 and Ca1) in the sacrum and tail were anteriorized in Hoxd-9-/- mutants [7].
  • Whereas E13 1/2 homozygous Wsh/Wsh embryos essentially lacked c-kit-positive cells in the skin, E13 1/2 heterozygous Wsh/+ embryos had reduced numbers of melanoblasts compared to +/+ with few or none in the lumbar region (future sash) [8].
  • At E13 1/2 +/+ embryos had a graded distribution of melanoblasts from cranial to caudal with a minimum in the lumbar region [8].
  • This work defines a critical window of development in the late gastrula-stage embryo when vitamin A is essential for normal axial skeletal patterning and shows that vitamin A deficiency causes anterior homeotic transformations extending from the cervical to lumbosacral regions [9].

Chemical compound and disease context of Lumbosacral Region


Biological context of Lumbosacral Region


Anatomical context of Lumbosacral Region


Associations of Lumbosacral Region with chemical compounds


Gene context of Lumbosacral Region


Analytical, diagnostic and therapeutic context of Lumbosacral Region


  1. Distribution of retroperitoneal lymph node metastases in patients with non-seminomatous testicular cancer in clinical stage I. Fosså, S.D., Ous, S., Stenwig, A.E., Lien, H.H., Aass, N., Kaalhus, O. Eur. Urol. (1990) [Pubmed]
  2. Rhabdomyolysis following laparoscopic gastric bypass. Filis, D., Daskalakis, M., Askoxylakis, I., Metaxari, M., Melissas, J. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (2005) [Pubmed]
  3. Pachymeningeal gadolinium enhancement of the lumbar region secondary to neuraxis hypotension. Fedder, S.L. Spine. (1999) [Pubmed]
  4. Comparison of ultrasonography and pharmacokinetic analysis of creatine kinase release for quantitative assessment of postinjection muscle damage in sheep. Ferré, P.J., Concordet, D., Laroute, V., Chanoit, G.P., Ferré, J.P., Manesse, M., Lefebvre, H.P. Am. J. Vet. Res. (2001) [Pubmed]
  5. Expression of a new mutation (Axd) causing axial defects in mice correlates with maternal phenotype and age. Essien, F.B., Haviland, M.B., Naidoff, A.E. Teratology (1990) [Pubmed]
  6. A VIP-containing system concentrated in the lumbosacral region of human spinal cord. Anand, P., Gibson, S.J., McGregor, G.P., Blank, M.A., Ghatei, M.A., Bacarese-Hamilton, A.J., Polak, J.M., Bloom, S.R. Nature (1983) [Pubmed]
  7. Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning. Fromental-Ramain, C., Warot, X., Lakkaraju, S., Favier, B., Haack, H., Birling, C., Dierich, A., Doll e, P., Chambon, P. Development (1996) [Pubmed]
  8. W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis. Duttlinger, R., Manova, K., Chu, T.Y., Gyssler, C., Zelenetz, A.D., Bachvarova, R.F., Besmer, P. Development (1993) [Pubmed]
  9. Vitamin A deficiency in the late gastrula stage rat embryo results in a one to two vertebral anteriorization that extends throughout the axial skeleton. Kaiser, M.E., Merrill, R.A., Stein, A.C., Breburda, E., Clagett-Dame, M. Dev. Biol. (2003) [Pubmed]
  10. Surgically confirmed myelographic classification of congenital intraspinal lipoma in the lumbosacral region. Sato, K., Shimoji, T., Sumie, H., Yaguchi, K., Yagishita, A., Kuru, Y., Ishii, S. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (1985) [Pubmed]
  11. Combination chemotherapy (cisplatin, vinblastin) and low-dose irradiation in the treatment of pineal parenchymal cell tumors. Kurisaka, M., Arisawa, M., Mori, T., Sakamoto, T., Seike, M., Mori, K., Okada, T., Wakiguchi, H., Kurashige, T. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. (1998) [Pubmed]
  12. The impact of degenerative conditions in the spine on bone mineral density and fracture risk prediction. von der Recke, P., Hansen, M.A., Overgaard, K., Christiansen, C. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (1996) [Pubmed]
  13. Rhythms of serum melatonin in patients with spinal lesions at the cervical, thoracic or lumbar region. Li, Y., Jiang, D.H., Wang, M.L., Jiao, D.R., Pang, S.F. Clin. Endocrinol. (Oxf) (1989) [Pubmed]
  14. Bronchial, cardiovascular and secretory responses after central administration of capsaicin in the guinea-pig. Gamse, R., Martling, C.R., Saria, A., Lundberg, J.M. Naunyn Schmiedebergs Arch. Pharmacol. (1986) [Pubmed]
  15. Assessment of intraspinal and intracranial conduction by P30 and P39 tibial nerve somatosensory evoked potentials in cervical cord, brainstem, and hemispheric lesions. Tinazzi, M., Mauguière, F. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. (1995) [Pubmed]
  16. Influence of slaughter weight on growth and carcass characteristics, commercial cutting and curing yields, and meat quality of barrows and gilts from two genotypes. Cisneros, F., Ellis, M., McKeith, F.K., McCaw, J., Fernando, R.L. J. Anim. Sci. (1996) [Pubmed]
  17. Norepinephrine depletion in the spinal cord gray matter of rats with experimental allergic encephalomyelitis. White, S.R., Bhatnagar, R.K., Bardo, M.T. J. Neurochem. (1983) [Pubmed]
  18. Ossification of the posterior longitudinal ligament: a clinico-radiological study of 74 cases. Nose, T., Egashira, T., Enomoto, T., Maki, Y. J. Neurol. Neurosurg. Psychiatr. (1987) [Pubmed]
  19. Differences in spinal distribution and neurochemical phenotype of colonic afferents in mouse and rat. Christianson, J.A., Traub, R.J., Davis, B.M. J. Comp. Neurol. (2006) [Pubmed]
  20. Spinal cord acetylcholine content: the consequence of transection or treatment with the neurotoxin 6-aminonicotinamide. Potter, P.E., Neff, N.H. Brain Res. (1984) [Pubmed]
  21. Blockade of the spinal excitatory effect of cAMP on the startle reflex by intrathecal administration of the isoquinoline sulfonamide H-8: comparison to the protein kinase C inhibitor H-7. Boulis, N.M., Davis, M. Brain Res. (1990) [Pubmed]
  22. Concentration gradients for HVA, 5-HIAA, ascorbic acid, and uric acid in cerebrospinal fluid. Degrell, I., Nagy, E. Biol. Psychiatry (1990) [Pubmed]
  23. Neonatal guanethidine sympathectomy suppresses autotomy and prevents changes in spinal and supraspinal monoamine levels induced by peripheral deafferentation in rats. Colado, M.I., Del Rio, J., Peralta, E. Pain (1994) [Pubmed]
  24. Intraspinal alumina injection: the relationship between epileptiform focus, root scarring and chronic pain. Loeser, J.D., Peirce, K.R. Pain (1978) [Pubmed]
  25. Central nervous system chloramphenicol concentration in premature infants. Dunkle, L.M. Antimicrob. Agents Chemother. (1978) [Pubmed]
  26. Pharmacokinetics of technetium-99m diphosphonate. Castronovo, F.P., Guiberteau, M.J., Berg, G., McKusick, K.A., Callahan, R.J., Potsaid, M.S. J. Nucl. Med. (1977) [Pubmed]
  27. Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord. Colbert, M.C., Rubin, W.W., Linney, E., LaMantia, A.S. Dev. Dyn. (1995) [Pubmed]
  28. Afferent input modulates neurotrophins and synaptic plasticity in the spinal cord. Gómez-Pinilla, F., Ying, Z., Roy, R.R., Hodgson, J., Edgerton, V.R. J. Neurophysiol. (2004) [Pubmed]
  29. Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling. Tocharus, J., Tsuchiya, A., Kajikawa, M., Ueta, Y., Oka, C., Kawaichi, M. Dev. Growth Differ. (2004) [Pubmed]
  30. Evidence of spinocerebellar mossy fiber segregation in the juvenile staggerer cerebellum. Ji, Z., Jin, Q., Vogel, M.W. J. Comp. Neurol. (1997) [Pubmed]
  31. Expression of splice variants of the NR1 subunit of the N-methyl-D-aspartate receptor in the normal and injured rat spinal cord. Prybylowski, K.L., Grossman, S.D., Wrathall, J.R., Wolfe, B.B. J. Neurochem. (2001) [Pubmed]
  32. Alteration of spinal cord IGF-I receptors and skeletal muscle IGF-I after hind-limb immobilization in the rat. Suliman, I.A., Lindgren, J.U., Gillberg, P.G., Elhassan, A.M., Monneron, C., Adem, A. Neuroreport (1999) [Pubmed]
  33. Neuroendocrine and behavioral effects of intrathecal capsaicin in adult female rats. Nance, D.M., King, T.R., Nance, P.W. Brain Res. Bull. (1987) [Pubmed]
  34. Chronic topical application of all-trans-retinoic acid in man does not affect corneocyte surface area. Robinson, S.M., Poncet, M., Ferracin, J., Czernielewski, J., Verschoore, M. Skin Pharmacol. (1994) [Pubmed]
  35. Autoradiographic localization of substance P receptors in rat spinal cord: effects of experimental spinal transection. Vita, G., Haun, C.K., Hawkins, E.F., Engel, W.K. Funct. Neurol. (1987) [Pubmed]
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