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Chemical Compound Review:

AG-G-89788 ethyl icosa-2,4,6,8,10-pentaenoate

Synonyms: CTK5D7766, Eicosapentaenoic acid,ethyl ester, EPA 90E;Ethyl icosapentate; Incromega E 7010

Teraoka, R. et al., Kusunoki, M. et al., Konya, E. et al., Nakamura, H. et al.

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Disease relevance of ethyl icosapentate

Ethyl icosapentate (EPA) is known to improve insulin resistance in non-insulin-dependent diabetes mellitus (NIDDM); however, its mechanism is unclear [1].
Evaluation of ethyl icosapentate in the treatment of hypercholesterolemia in kidney transplant recipients [2].
BACKGROUND: The effect of ethyl icosapentate (EPA-E) on urinary calcium and oxalic acid excretion was examined to evaluate whether EPA-E is useful in the prevention of calcium-containing urinary stones [3].

High impact information on ethyl icosapentate

Chemical stability of ethyl icosapentate against autoxidation. II. Effect of photoirradiation on oxidation kinetics [4].
Ethyl icosapentate (omega-3 fatty acid) causes accumulation of lipids in skeletal muscle but suppresses insulin resistance in OLETF rats. Otsuka Long-Evans Tokushima Fatty [1].

Analytical, diagnostic and therapeutic context of ethyl icosapentate

The effect of ultraviolet (UV) or visible light (VIS) irradiation on the chemical stability of ethyl icosapentate [ethyl-(all-cis)-5,8,11,14,17-icosapentaenoate] (EPA) was investigated at 45 degrees C by means of HPLC and by measuring the peroxide value (POV) [4].

References

Ethyl icosapentate (omega-3 fatty acid) causes accumulation of lipids in skeletal muscle but suppresses insulin resistance in OLETF rats. Otsuka Long-Evans Tokushima Fatty. Kusunoki, M., Tsutsumi, K., Hara, T., Ogawa, H., Nakamura, T., Miyata, T., Sakakibara, F., Fukuzawa, Y., Suga, T., Kato, K., Hirooka, Y., Nakaya, Y. Metab. Clin. Exp. (2003) [Pubmed]
Evaluation of ethyl icosapentate in the treatment of hypercholesterolemia in kidney transplant recipients. Nakamura, H., Asano, T., Suzuki, S., Tokonabe, S., Hayakawa, M. Transplant. Proc. (1998) [Pubmed]
Effect of ethyl icosapentate on urinary calcium and oxalate excretion. Konya, E., Tsuji, H., Umekawa, T., Kurita, T., Iguchi, M. International journal of urology : official journal of the Japanese Urological Association. (2000) [Pubmed]
Chemical stability of ethyl icosapentate against autoxidation. II. Effect of photoirradiation on oxidation kinetics. Teraoka, R., Otsuka, M., Matsuda, Y. Pharm. Res. (1994) [Pubmed]

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