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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Light


High impact information on Light


Chemical compound and disease context of Light


Biological context of Light


Anatomical context of Light


Associations of Light with chemical compounds


Gene context of Light

  • Importantly, ppk25 mutant males that show no response to females in the dark execute all of the normal steps of courtship behavior in the presence of visible light, suggesting that ppk25 is required for activation of courtship behavior by chemosensory perception of female pheromones [30].
  • UVR2 and UVR3 products were previously identified as photolyases that remove UV-induced pyrimidine dimers in the presence of visible light [31].
  • The catalytic activity of the recombinant wild-type IVD was the highest in the presence of isovaleryl-CoA, and its UV/visible light spectrum in the presence of isovaleryl-CoA showed quenching of its characteristic absorption in the 445-nm region and appearance of absorption at 600 nm [32].
  • This partial impairment of the cutaneous antioxidant defense system by near ultraviolet/visible light, showing that the most susceptible component in skin is catalase, suggests possible pharmacological interventions [33].
  • METHODS: Wildtype and c-fos-/- mice were exposed to low (roomlight) or high levels of visible light for up to two hours [34].

Analytical, diagnostic and therapeutic context of Light


  1. Immunological suppression in mice treated with hematoporphyrin derivative photoradiation. Elmets, C.A., Bowen, K.D. Cancer Res. (1986) [Pubmed]
  2. Histopathological comparison of the effects of hematoporphyrin derivative on two different murine tumors using computer-enhanced digital video fluorescence microscopy. Nelson, J.S., Wright, W.H., Berns, M.W. Cancer Res. (1985) [Pubmed]
  3. Photosensitization with anticancer agents. 20--EPR studies on the photodynamic action of phleichrome: formation of semiquinone radical and activated oxygen species on illumination with visible light. Diwu, Z., Lown, J.W. Free Radic. Biol. Med. (1995) [Pubmed]
  4. Formation and properties of a covalent complex between elongation factor Tu and Phe-tRNA bearing a photoaffinity probe on its 3-(3-amino-3-carboxypropyl)uridine residue. Kao, T., Miller, D.L., Abo, M., Ofengand, J. J. Mol. Biol. (1983) [Pubmed]
  5. Evaluation of the effects of photoradiation therapy on brain tumors with in vivo P-31 MR spectroscopy. Naruse, S., Horikawa, Y., Tanaka, C., Higuchi, T., Sekimoto, H., Ueda, S., Hirakawa, K. Radiology. (1986) [Pubmed]
  6. Visible-light photocatalysis in nitrogen-doped titanium oxides. Asahi, R., Morikawa, T., Ohwaki, T., Aoki, K., Taga, Y. Science (2001) [Pubmed]
  7. Bacteriophytochromes: phytochrome-like photoreceptors from nonphotosynthetic eubacteria. Davis, S.J., Vener, A.V., Vierstra, R.D. Science (1999) [Pubmed]
  8. Oxidative thymine dimer repair in the DNA helix. Dandliker, P.J., Holmlin, R.E., Barton, J.K. Science (1997) [Pubmed]
  9. Purinergic receptors: photoaffinity analog of adenosine triphosphate is a specific adenosine triphosphate antagonist. Hogaboom, G.K., O'Donnell, J.P., Fedan, J.S. Science (1980) [Pubmed]
  10. Photoradiation in the treatment of recurrent breast carcinoma. Dougherty, T.J., Lawrence, G., Kaufman, J.H., Boyle, D., Weishaupt, K.R., Goldfarb, A. J. Natl. Cancer Inst. (1979) [Pubmed]
  11. Photosensitization with anticancer agents 19. EPR studies of photodynamic action of calphostin C: formation of semiquinone radical and activated oxygen on illumination with visible light. Diwu, Z., Lown, J.W. Free Radic. Biol. Med. (1994) [Pubmed]
  12. Efficient photoinduced conversion of an azo dye on hexachloroplatinate(IV)-modified TiO2 surfaces under visible light irradiation-A photosensitization pathway. Zhao, W., Chen, C., Ma, W., Zhao, J., Wang, D., Hidaka, H., Serpone, N. Chemistry (Weinheim an der Bergstrasse, Germany) (2003) [Pubmed]
  13. Substrate specificity of the Escherichia coli Fpg protein (formamidopyrimidine-DNA glycosylase): excision of purine lesions in DNA produced by ionizing radiation or photosensitization. Boiteux, S., Gajewski, E., Laval, J., Dizdaroglu, M. Biochemistry (1992) [Pubmed]
  14. Systemic photodynamic therapy with aminolevulinic acid induces apoptosis in lesional T lymphocytes of psoriatic plaques. Bissonnette, R., Tremblay, J.F., Juzenas, P., Boushira, M., Lui, H. J. Invest. Dermatol. (2002) [Pubmed]
  15. Suppression of graft-versus-host reactivity in the mouse popliteal node by UVB radiation. Morison, W.L., Pike, R.A. J. Invest. Dermatol. (1985) [Pubmed]
  16. Phototransformation of green fluorescent protein with UV and visible light leads to decarboxylation of glutamate 222. van Thor, J.J., Gensch, T., Hellingwerf, K.J., Johnson, L.N. Nat. Struct. Biol. (2002) [Pubmed]
  17. Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea. Kutty, R.K., Kutty, G., Wiggert, B., Chader, G.J., Darrow, R.M., Organisciak, D.T. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  18. Relationship of mitochondrial function and cellular adenosine triphosphate levels to hematoporphyrin derivative-induced photosensitization in R3230AC mammary tumors. Hilf, R., Murant, R.S., Narayanan, U., Gibson, S.L. Cancer Res. (1986) [Pubmed]
  19. The assessment of bone formation and bone resorption in osteoporosis: a comparison between tetracycline-based iliac histomorphometry and whole body 85Sr kinetics. Reeve, J., Arlot, M.E., Chavassieux, P.M., Edouard, C., Green, J.R., Hesp, R., Tellez, M., Meunier, P.J. J. Bone Miner. Res. (1987) [Pubmed]
  20. Mimicking biological electron transport in sol-gel glass: photoinduced electron transfer from zinc cytochrome C to plastocyanin or cytochrome C mediated by mobile inorganic complexes. Pletneva, E.V., Crnogorac, M.M., Kostić, N.M. J. Am. Chem. Soc. (2002) [Pubmed]
  21. P-glycoprotein targeting: a unique strategy to selectively eliminate immunoreactive T cells. Guimond, M., Balassy, A., Barrette, M., Brochu, S., Perreault, C., Roy, D.C. Blood (2002) [Pubmed]
  22. Photoradiation models for the clinical ex vivo treatment of autologous bone marrow grafts. Atzpodien, J., Gulati, S.C., Strife, A., Clarkson, B.D. Blood (1987) [Pubmed]
  23. Inhibition of mammalian DNA polymerases by hematoporphyrin derivative and photoradiation. Crute, J.J., Wahl, A.F., Bambara, R.A., Murant, R.S., Gibson, S.L., Hilf, R. Cancer Res. (1986) [Pubmed]
  24. In vitro studies on the photobiological properties of aloe emodin and aloin A. Wamer, W.G., Vath, P., Falvey, D.E. Free Radic. Biol. Med. (2003) [Pubmed]
  25. Mutagenicity of the fullerene C60-generated singlet oxygen dependent formation of lipid peroxides. Sera, N., Tokiwa, H., Miyata, N. Carcinogenesis (1996) [Pubmed]
  26. Mechanisms of resistance to beta-lactam antibiotics in strains of Staphylococcus aureus. Sabath, L.D. Ann. Intern. Med. (1982) [Pubmed]
  27. Crystal structure of thermostable DNA photolyase: pyrimidine-dimer recognition mechanism. Komori, H., Masui, R., Kuramitsu, S., Yokoyama, S., Shibata, T., Inoue, Y., Miki, K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  28. Chemistry for the analysis of protein-protein interactions: rapid and efficient cross-linking triggered by long wavelength light. Fancy, D.A., Kodadek, T. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  29. Cytochrome oxidase (a3) heme and copper observed by low-temperature Fourier transform infrared spectroscopy of the CO complex. Alben, J.O., Moh, P.P., Fiamingo, F.G., Altschuld, R.A. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  30. A Drosophila DEG/ENaC channel subunit is required for male response to female pheromones. Lin, H., Mann, K.J., Starostina, E., Kinser, R.D., Pikielny, C.W. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  31. Repair of UV damage in plants by nucleotide excision repair: Arabidopsis UVH1 DNA repair gene is a homolog of Saccharomyces cerevisiae Rad1. Liu, Z., Hossain, G.S., Islas-Osuna, M.A., Mitchell, D.L., Mount, D.W. Plant J. (2000) [Pubmed]
  32. Identification of the active site catalytic residue in human isovaleryl-CoA dehydrogenase. Mohsen, A.W., Vockley, J. Biochemistry (1995) [Pubmed]
  33. Acute effects of near ultraviolet and visible light on the cutaneous antioxidant defense system. Fuchs, J., Huflejt, M.E., Rothfuss, L.M., Wilson, D.S., Carcamo, G., Packer, L. Photochem. Photobiol. (1989) [Pubmed]
  34. Gene expression in the mouse retina: the effect of damaging light. Grimm, C., Wenzel, A., Hafezi, F., Remé, C.E. Mol. Vis. (2000) [Pubmed]
  35. Effects of photosensitization by hematoporphyrin derivative on mitochondrial adenosine triphosphatase-mediated proton transport and membrane integrity of R3230AC mammary adenocarcinoma. Perlin, D.S., Murant, R.S., Gibson, S.L., Hilf, R. Cancer Res. (1985) [Pubmed]
  36. Photoreduction of the fluorescent dye 2'-7'-dichlorofluorescein: a spin trapping and direct electron spin resonance study with implications for oxidative stress measurements. Marchesi, E., Rota, C., Fann, Y.C., Chignell, C.F., Mason, R.P. Free Radic. Biol. Med. (1999) [Pubmed]
  37. High-pressure liquid chromatographic analysis of anaerobic photoproducts of bilirubin-IX alpha in vitro and its comparison with photoproducts in vivo. Onishi, S., Kawade, N., Itoh, S., Isobe, K., Sugiyama, S. Biochem. J. (1980) [Pubmed]
  38. Light history and age-related changes in retinal light damage. Organisciak, D.T., Darrow, R.M., Barsalou, L., Darrow, R.A., Kutty, R.K., Kutty, G., Wiggert, B. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  39. Cervical tissue and plasma concentrations of alpha-carotene and beta-carotene in women are correlated. Gamboa-Pinto, A.J., Rock, C.L., Ferruzzi, M.G., Schowinsky, A.B., Schwartz, S.J. J. Nutr. (1998) [Pubmed]
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