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Chemical Compound Review

AC1O530E     (2R)-2-[[(2S)-2-amino-4- methyl...

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Disease relevance of Leu-Trp


High impact information on Leu-Trp

  • The four LHRHs known to occur in nature involve a total of six amino acids (Tyr, His, Leu, Trp, Arg, Gln) in positions 5, 7, and 8 [3].
  • To determine whether such contacts influence the dNTP-binding pocket, we performed a limited vertical scanning mutagenesis (Phe --> Ala, Leu, Trp, or Tyr) at Phe(61) [4].
  • Furthermore, in reticulocytes, distinct types of the N-end-recognizing activity are shown to be specific for three classes of primary destabilizing residues: basic (Arg, Lys, His), bulky hydrophobic (Phe, Leu, Trp, Tyr), and small uncharged (Ala, Ser, Thr) [5].
  • There was geographic variation in the frequency of occurrence of particular rpoB mutations, with the Ser531 --> Leu/Trp codon mutation found in 59/113 of isolates [6].

Analytical, diagnostic and therapeutic context of Leu-Trp

  • These peptides were identified by amino acid composition analysis, sequence analysis, and liquid chromatography-mass spectrometry (LC-MS), as Val-Tyr (IC(50) = 35.2 microM), Ile-Tyr (6.1 microM), Ala-Trp (18.8 microM), Phe-Tyr (42.3 microM), Val-Trp (3.3 microM), Ile-Trp (1.5 microM), and Leu-Trp (23.6 microM) [7].


  1. Enzymatic modification of tryptophan residues by tryptophan side chain oxidase I and II from Pseudomonas. Ito, S., Takai, K., Tokuyama, T., Hayaishi, O. J. Biol. Chem. (1981) [Pubmed]
  2. The characterization of mutant Bacillus subtilis adenylosuccinate lyases corresponding to severe human adenylosuccinate lyase deficiencies. Palenchar, J.B., Crocco, J.M., Colman, R.F. Protein Sci. (2003) [Pubmed]
  3. Decapeptides as effective agonists from L-amino acids biologically equivalent to the luteinizing hormone-releasing hormone. Folkers, K., Bowers, C.Y., Tang, P.F., Kubota, M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  4. Substitutions of Phe61 located in the vicinity of template 5'-overhang influence polymerase fidelity and nucleoside analog sensitivity of HIV-1 reverse transcriptase. Fisher, T.S., Prasad, V.R. J. Biol. Chem. (2002) [Pubmed]
  5. Universality and structure of the N-end rule. Gonda, D.K., Bachmair, A., Wünning, I., Tobias, J.W., Lane, W.S., Varshavsky, A. J. Biol. Chem. (1989) [Pubmed]
  6. Comparison of PCR-heteroduplex characterization by automated DNA sequencing and line probe assay for the detection of rifampicin resistance in Mycobacterium tuberculosis isolates from KwaZulu-Natal, South Africa. Kiepiela, P., Bishop, K., Kormuth, E., Roux, L., York, D.F. Microb. Drug Resist. (1998) [Pubmed]
  7. Angiotensin I-converting enzyme inhibitory peptides derived from wakame (Undaria pinnatifida) and their antihypertensive effect in spontaneously hypertensive rats. Sato, M., Hosokawa, T., Yamaguchi, T., Nakano, T., Muramoto, K., Kahara, T., Funayama, K., Kobayashi, A., Nakano, T. J. Agric. Food Chem. (2002) [Pubmed]
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