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Chemical Compound Review

Delprostenate     methyl(2Z,5Z)-7-[(2S)-2- [(E,3S)-4-(3...

Synonyms: Delprostenato, Delprostenatum, CHEMBL2104606, AC1O5IEM, LS-74202, ...
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Disease relevance of Delprostenate


High impact information on Delprostenate

  • On the other hand, the five control cows with luteinized cysts that were not treated with ONO-1052 required significantly longer to exhibit normal estrus (54 +/- 13 days; P<0.05) and to conceive (54 +/- 13 days) [1].

Associations of Delprostenate with other chemical compounds

  • Of the 18 cows with luteinized cysts thus confirmed following fertirelin injection and treated with ONO-1052, 15 (83.3 %) cows came into estrus within 26 +/- 14 (mean +/- SD) days after the first treatment; eight cows within three to five days and four cows within 22 to 28 days, and 14 cows (77.8 %) conceived within 100 days (42 +/- 26 days) [1].
  • A-2774 and SV-626 were the two most sensitive lines, especially when exposed to high concentrations of TNF [2].

Analytical, diagnostic and therapeutic context of Delprostenate

  • Only in the cows with luteinized cysts which were confirmed by serum progesterone analysis; increased from a pretreatment level below 1.0 ng/ml to a value of 1.0 ng/ml or higher 10 to 14 days after treatment, effects of ONO-1052 combined with fertirelin were investigated [1].


  1. Effects of an analog of PGF2(alpha) (ONO-1052) on cows with luteinized ovarian cysts following treatment with GnRH analog (fertirelin acetate). Nakao, T., Sugihashi, A., Kawata, K., Nakamura, H., Shirakawa, J., Iinuma, M., Tsurubayashi, M., Horiuchi, S. Theriogenology (1985) [Pubmed]
  2. Effect of recombinant human TNF on human ovarian cancer cell lines. Vigani, A., Miglietta, L., Chiara, S., Repetto, L., Pichi, E., Cimoli, G., Morelli, L., Poggi, L., Billi, G., Parodi, S. Boll. Soc. Ital. Biol. Sper. (1990) [Pubmed]
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