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MeSH Review

Follicular Cyst

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Disease relevance of Follicular Cyst


High impact information on Follicular Cyst

  • Besides normal hair formation, follicular cysts, misoriented and dysplastic follicles, together with aberrant hair cycling, were also observed in the p107/p130 skin transplants [6].
  • Effects observed include development of dermal follicular cysts, excessive skin wrinkling, enhanced nail growth, alopecia, and spontaneous tumor development [7].
  • Preceding the development of follicular cysts, there is an increase in intraovarian synthesis of nerve growth factor (NGF) and the low affinity NGF receptor (p75 NGFR) [8].
  • The steroidal responses of the gland to beta-adrenergic receptor stimulation and hCG were examined in vitro 60 days after EV administration, i.e. at the time when follicular cysts are well established [9].
  • The ability of these cysts to produce 1-2 ng estradiol in medium alone and even greater amounts of estradiol in the presence of exogenous androgen indicates that inhibition of the ability of FSH to induce and stimulate follicular aromatase activity is not a prerequisite for the induction of follicular cysts in these animals [10].

Chemical compound and disease context of Follicular Cyst

  • Finally, the increasing ability to accumulate androstenedione in the presence of exogenous testosterone suggests that follicular 17 beta-hydroxysteroid oxidoreductase activity increases in response to chronic stimulation by low doses of LH-like activity during the development of follicular cysts [10].
  • The effects of RU486 are reversible: 4 to 5 weeks after the end of treatment ovarian activity seems normal (as evidenced by reduction of ovarian weights and 5-day vaginal cycles) except for the presence of occasional large follicular cysts which may require longer periods for their regression [11].
  • The increase in PRL in the Thio, hCG-stimulated group coincides with formation of follicular cysts [12].
  • Unabated stimulation by low doses of LH-like activity produces ovarian follicular cysts in both progesterone-synchronized immature rats and pregnant rats [13].
  • Perturbation of estradiol-feedback control of luteinizing hormone secretion by immunoneutralization induces development of follicular cysts in cattle [14].

Biological context of Follicular Cyst


Anatomical context of Follicular Cyst


Gene context of Follicular Cyst

  • Women (n = 20) with ovarian endometriomata and 10 women with follicular cysts were enrolled in this study to investigate the role of VEGF and IL-8 in the development and maintenance of ovarian endometriomata [23].
  • The potential role of estrogen receptor-beta (ERbeta) in normal ovarian folliculogenesis and in reproductive disorders such as ovarian follicular cysts has not been well defined [24].
  • Dominant bovine ovarian follicular cysts express increased levels of messenger RNAs for luteinizing hormone receptor and 3 beta-hydroxysteroid dehydrogenase delta(4),delta(5) isomerase compared to normal dominant follicles [25].
  • Numerous keratin-filled follicular cysts develop over extensive areas of the skin, usually between the age of 2 and 26 years [26].
  • However, the ovaries from the cases demonstrated a significantly greater number of follicular cysts with staining for StAR immunoreactivity in the thecal cells than did the ovaries from healthy women (100% vs 38%, P <.05) [27].

Analytical, diagnostic and therapeutic context of Follicular Cyst


  1. Transient induction of polycystic ovary-like syndrome in immature hypothyroid rats. Bagavandoss, P., England, B., Asirvatham, A., Bruot, B.C. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  2. Vascular endothelial growth factor and interleukin-8 in ovarian cystic pathology. Fasciani, A., D'Ambrogio, G., Bocci, G., Luisi, S., Artini, P.G., Genazzani, A.R. Fertil. Steril. (2001) [Pubmed]
  3. Involvement of nitric oxide and the ovarian blood follicle barrier in murine follicular cyst development. Nemade, R.V., Carrette, O., Larsen, W.J., Markoff, E. Fertil. Steril. (2002) [Pubmed]
  4. Reproductive performance of lactating Holstein cows fed supplemental beta-carotene. Akordor, F.Y., Stone, J.B., Walton, J.S., Leslie, K.E., Buchanan-Smith, J.G. J. Dairy Sci. (1986) [Pubmed]
  5. Aspiration cytology of ovarian cysts and cystic neoplasms. A study of 235 aspirates. Mulvany, N.J. Acta Cytol. (1996) [Pubmed]
  6. Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130. Ruiz, S., Segrelles, C., Bravo, A., Santos, M., Perez, P., Leis, H., Jorcano, J.L., Paramio, J.M. Development (2003) [Pubmed]
  7. Increased frequency of spontaneous skin tumors in transgenic mice which overexpress ornithine decarboxylase. Megosh, L., Gilmour, S.K., Rosson, D., Soler, A.P., Blessing, M., Sawicki, J.A., O'Brien, T.G. Cancer Res. (1995) [Pubmed]
  8. Intraovarian excess of nerve growth factor increases androgen secretion and disrupts estrous cyclicity in the rat. Dissen, G.A., Lara, H.E., Leyton, V., Paredes, A., Hill, D.F., Costa, M.E., Martinez-Serrano, A., Ojeda, S.R. Endocrinology (2000) [Pubmed]
  9. Ovarian steroidal response to gonadotropins and beta-adrenergic stimulation is enhanced in polycystic ovary syndrome: role of sympathetic innervation. Barria, A., Leyton, V., Ojeda, S.R., Lara, H.E. Endocrinology (1993) [Pubmed]
  10. Induction of ovarian cysts in progesterone-synchronized immature rats: evidence that suppression of follicular aromatase activity is not a prerequisite for the induction of cystic follicles. Bogovich, K. Endocrinology (1989) [Pubmed]
  11. Effects of the progesterone antagonist RU486 on ovarian activity in the rat. van der Schoot, P., Bakker, G.H., Klijn, J.G. Endocrinology (1987) [Pubmed]
  12. Relationship of polycystic ovary induction to prolactin secretion: prevention of cyst formation by bromocriptine in the rat. Copmann, T.L., Adams, W.C. Endocrinology (1981) [Pubmed]
  13. Follicle-stimulating hormone plays a role in the induction of ovarian follicular cysts in hypophysectomized rats. Bogovich, K. Biol. Reprod. (1992) [Pubmed]
  14. Perturbation of estradiol-feedback control of luteinizing hormone secretion by immunoneutralization induces development of follicular cysts in cattle. Kaneko, H., Todoroki, J., Noguchi, J., Kikuchi, K., Mizoshita, K., Kubota, C., Yamakuchi, H. Biol. Reprod. (2002) [Pubmed]
  15. Use of milk progesterone enzyme immunoassay for differential diagnosis of follicular cyst, luteal cyst, and cystic corpus luteum in cows. Nakao, T., Sugihashi, A., Saga, N., Tsunoda, N., Kawata, K. Am. J. Vet. Res. (1983) [Pubmed]
  16. The role of LH pulse frequency in ACTH-induced ovarian follicular cysts in heifers. Ribadu, A.Y., Nakada, K., Moriyoshi, M., Zhang, W.C., Tanaka, Y., Nakao, T. Anim. Reprod. Sci. (2000) [Pubmed]
  17. Reproductive performance of dairy cows with cystic ovaries following administration of Procystin. Ax, R.L., Bellin, M.E., Schneider, D.K., Haase-Hardie, J.A., Mares, S.E. J. Dairy Sci. (1986) [Pubmed]
  18. An ultrasonographic study of bovine cystic ovarian disease and its treatment. Jeffcoate, I.A., Ayliffe, T.R. Vet. Rec. (1995) [Pubmed]
  19. A comparison of adrenal gland function in lactating dairy cows with or without ovarian follicular cysts. Silvia, W.J., McGinnis, A.S., Hatler, T.B. Reproductive biology. (2005) [Pubmed]
  20. Multiple pigmented follicular cysts of the vulva successfully treated with CO2 laser: case report and literature review. Chuang, Y.H., Hong, H.S., Kuo, T.T. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. (2004) [Pubmed]
  21. A follicular cyst during tamoxifen therapy in a premenopausal breast cancer woman. Terada, S., Uchide, K., Suzuki, N., Akasofu, K. Gynecol. Obstet. Invest. (1993) [Pubmed]
  22. Ovarian pathology in chronic pelvic inflammatory disease. Bychkov, V. Gynecol. Obstet. Invest. (1990) [Pubmed]
  23. High concentrations of the vascular endothelial growth factor and interleukin-8 in ovarian endometriomata. Fasciani, A., D'Ambrogio, G., Bocci, G., Monti, M., Genazzani, A.R., Artini, P.G. Mol. Hum. Reprod. (2000) [Pubmed]
  24. Cloning, sequencing, and localization of bovine estrogen receptor-beta within the ovarian follicle. Rosenfeld, C.S., Yuan, X., Manikkam, M., Calder, M.D., Garverick, H.A., Lubahn, D.B. Biol. Reprod. (1999) [Pubmed]
  25. Dominant bovine ovarian follicular cysts express increased levels of messenger RNAs for luteinizing hormone receptor and 3 beta-hydroxysteroid dehydrogenase delta(4),delta(5) isomerase compared to normal dominant follicles. Calder, M.D., Manikkam, M., Salfen, B.E., Youngquist, R.S., Lubahn, D.B., Lamberson, W.R., Garverick, H.A. Biol. Reprod. (2001) [Pubmed]
  26. Atrichia with papular lesions. Kanzler, M.H., Rasmussen, J.E. Archives of dermatology. (1986) [Pubmed]
  27. Steroidogenic acute regulatory protein (StAR) in the ovaries of healthy women and those with polycystic ovary syndrome. Kahsar-Miller, M.D., Conway-Myers, B.A., Boots, L.R., Azziz, R. Am. J. Obstet. Gynecol. (2001) [Pubmed]
  28. Formation of ovarian follicular cysts and corpora lutea after treatment with antihistamine or indomethacin in prepubertal gilts. Hall, J.A., Meisterling, E.M., Lewis, P.E., Dailey, R.A. Biol. Reprod. (1989) [Pubmed]
  29. Effect of LHRH agonist, Zoladex, on ovarian histology. Williamson, K., Robertson, J.F., Ellis, I.O., Elston, C.W., Nicholson, R.I., Blamey, R.W. The British journal of surgery. (1988) [Pubmed]
  30. Transrectal ultrasonic diagnosis of ovarian follicular cysts in goats and treatment with GnRH. Medan, M.S., Watanabe, G., Sasaki, K., Taya, K. Domest. Anim. Endocrinol. (2004) [Pubmed]
  31. Dexamethasone-suppressible hypercorticosteronism in two 46,XX subjects with ambiguous genitalia and ovarian cysts. Partial defect of 17 alpha-hydroxylase or 17-20-desmolase. Roger, M., Merceron, R.E., Girard, F., Canlorbe, P., Dehennin, L., Konopka, P., Seneze, J., Toublanc, J.E. Horm. Res. (1982) [Pubmed]
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