Disease relevance of Fertirelin

• This field study compared the efficacy of a single injection of 200 mug fertirelin with that of 20 mug buserelin in shortening the recovery period of 68 laotating Holstein-Friesian cows with ovarian follicular cysts 65 d post partum or later [1].

High impact information on Fertirelin

• Mice in the superovulated with GnRH pretreatment group were given GnRH (20 mg/kg Fertirelin, i.m.), 24 h before superovulation [2].
• The effect of using a dose of 50 micro g rather than 100 micro g fertirelin in an ovulation/fixed-time insemination protocol for Holstein-Friesian dairy cows was investigated in three experiments [3].
• In experiment 2, a further 12 cows at 40-60 days postpartum were treated with 100 or 50 micro g fertirelin (n=6 per dose) with treatment commencing in the follicular or luteal phase of the oestrous cycle [3].
• Doses of 50 and 100 micro g fertirelin were compared in experiment 3 using 17 cows to study follicular wave development and synchronization by transrectal ultrasonography, conception rate and corpus luteum function [3].
• The bitches were treated with microencapsulated LA (100 micrograms/kg, s.c.) at 120 or 150 d post partum, or at 1 yr of age, followed by a GnRH-analogue (fertirelin; [Pro9NEt]-GnRH, 3 micrograms/kg, i.m.) on the first day of induced estrus [4].

Chemical compound and disease context of Fertirelin

• These results indicate that ONO-1052 combined with fertirelin may be useful to shorten the interval from treatment to normal estrus and to conception in cows with follicular cysts [5].
• Fertirelin and buserelin compared by LH release, milk progesterone and subsequent reproductive performance in dairy cows treated for follicular cysts [1].
• A further study on the dosage of an analog of luteinizing hormone-releasing hormone (fertirelin; Des-Gly10-LH-RH-ethylamide) for treatment of ovarian follicular cyst in cows [6].
• It was concluded that the administration of fenprostalene following fertirelin treatment is effective in shortening the interval from treatment to conception in cows with follicular cysts [7].

Biological context of Fertirelin

• Two days later, a second dose of fertirelin was given and AI performed 16-19 h later regardless of the incidence of behavioral oestrus.The effect on conception rate was studied in experiment 1 using 114 postpartum anoestrus cows [3].
• Luteinization, indicated by progesterone levels (>/= 1.0 ng/ml) 1 wk after treatment, was evidenced in 75% of the fertirelin group and 72% of the buserelin group [1].

Associations of Fertirelin with other chemical compounds

• Of the 18 cows with luteinized cysts thus confirmed following fertirelin injection and treated with ONO-1052, 15 (83.3 %) cows came into estrus within 26 +/- 14 (mean +/- SD) days after the first treatment; eight cows within three to five days and four cows within 22 to 28 days, and 14 cows (77.8 %) conceived within 100 days (42 +/- 26 days) [5].
• The effect of an intramuscular injection of a new analog of gonadotropin-releasing hormone (GnRH), fertirelin, on the first-service pregnancy rate in cows was investigated by a double blind experiment [8].
• Optimum dose of LH-RH analogue Fertirelin Acetate for the induction of superovulation in mice [9].

Analytical, diagnostic and therapeutic context of Fertirelin

• Enzyme immunoassay for the determination of des-Gly10-NH2-LH-RH-ethylamide (fertirelin) in bovine plasma [10].
• Seventy-five cows with follicular cysts diagnosed by rectal palpation were treated intramuscularly (i.m.) with 400 mug fertirelin (an analog of GnRH) [5].

References