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Chemical Compound Review:

AC1O5KZF [(14E)-9-[4-dimethylamino-3- hydroxy-5-(4...

Synonyms: LS-87912

Kondo, K., Fujisawa, Y. et al., Kikuchi, M. et al., Uyeda, M. et al.

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Disease relevance of Maridomycin III

Inducible macrolide-lincosamide-streptogramin resistance was found in S. fradiae NRRL 2702 and S. hygroscopicus IFO 12995, which synthesize the macrolides tylosin and maridomycin, respectively, as well as in the lincosamide producer Streptomyces lincolnensis NRRL 2936 and the streptogramin type B producer Streptomyces diastaticus NRRL 2560 [1].
Microbial transformation of maridomycin III by Serratia marcescens [2].
Antibiotics, the activity of which enhanced against Pseudomonas aeruginosa by SP127, were restricted to the basic macrolide antibiotics such as erythromycin, maridomycin and oleandomycin, the neutral macrolide antibiotics such as lankamycin and lankacidin C, vancomycin and enramycin [3].

High impact information on Maridomycin III

A linear relationship was found between the logarithm of the capacity factors (k') and the logarithm of the alkyl carbon numbers in the acyl group at position 4''. This relationship led to the discovery of a new component of maridomycin (3-propionyl-4''-n-butyryl analogue) in a crude sample [4].

Analytical, diagnostic and therapeutic context of Maridomycin III

Analytical studies of maridomycin. I. High-performance liquid chromatography of marido-mycins and some other macrolide antibiotics [4].
Two transformation products of maridomycin (MDM) III, MDM-S1 and MDM-S2 named after Serratia marcescens, were isolated by silica gel chromatography [2].

References

A family of r-determinants in Streptomyces spp. that specifies inducible resistance to macrolide, lincosamide, and streptogramin type B antibiotics. Fujisawa, Y., Weisblum, B. J. Bacteriol. (1981) [Pubmed]
Microbial transformation of maridomycin III by Serratia marcescens. Uyeda, M., Kubota, K., Miyamura, S., Shibata, M. J. Antibiot. (1983) [Pubmed]
Mode of action of the protein, SP127, which enhances the activity of macrolide antibiotics against Pseudomonas aeruginosa. Kikuchi, M., Nakao, Y. J. Antibiot. (1977) [Pubmed]
Analytical studies of maridomycin. I. High-performance liquid chromatography of marido-mycins and some other macrolide antibiotics. Kondo, K. J. Chromatogr. (1979) [Pubmed]

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