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Chemical Compound Review

SureCN146008     (2S,5R,6R)-6-[[(2R)-2-[[3- (2...

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Disease relevance of BAY Vk 4999

  • Similar morphological alterations are known to develop in wild type E. coli cells when furazlocillin is combined with bulgecin, an antibiotic of unusual glucosaminyl structure [1].
  • The results reveal that PBP-1A and PBP-1Bs functions are not equivalent since furazlocillin affects the morphology, autolysis, and murein synthesis of PBP1A- mutants quite differently from that of PBP-1Bs mutants [2].

High impact information on BAY Vk 4999


Chemical compound and disease context of BAY Vk 4999


Biological context of BAY Vk 4999


Associations of BAY Vk 4999 with other chemical compounds

  • The pharmacokinetics of the novel acylureidopenicillin furazlocillin, 6-[D-2-(3-furfurylidenamino-2-oxo-imidazolidine-1-carboxamido)-2 -(4-hydroxyphenyl)-acetamido]-penicillanic acid and of its penicilloic acid derivative were investigated in five healthy male volunteers after intravenous administration of 2 and 4 g dosages [6].

Gene context of BAY Vk 4999

  • The effect of furazlocillin on the morphology, autolysis, and murein synthesis of E. coli mutants deficient in either PBP-1A, PBP-1Bs, or PBP-2 was studied [2].
  • Potential septation sites that have been structurally blocked by either the SOS division inhibitor, furazlocillin inhibition of PBP3, or inactivation of a TER pathway component, FtsA3, could be reactivated one doubling time after removal of the inhibitory agent in the presence of an active lon gene product [9].

Analytical, diagnostic and therapeutic context of BAY Vk 4999


  1. A murein hydrolase is the specific target of bulgecin in Escherichia coli. Templin, M.F., Edwards, D.H., Höltje, J.V. J. Biol. Chem. (1992) [Pubmed]
  2. Effects of furazlocillin, a beta-lactam antibiotic which binds selectively to penicillin-binding protein 3, on Escherichia coli mutants deficient in other penicillin-binding proteins. Schmidt, L.S., Botta, G., Park, J.T. J. Bacteriol. (1981) [Pubmed]
  3. In vitro activity of furazlocillin (Bay k 4999) compared with those of mezlocillin, piperacillin, and standard beta-lactam antibiotics. Gootz, T.D., Sanders, C.C., Sanders, W.E. Antimicrob. Agents Chemother. (1979) [Pubmed]
  4. Differential effect of mutational impairment of penicillin-binding proteins 1A and 1B on Escherichia coli strains harboring thermosensitive mutations in the cell division genes ftsA, ftsQ, ftsZ, and pbpB. García del Portillo, F., de Pedro, M.A. J. Bacteriol. (1990) [Pubmed]
  5. Rule governing the division pattern in Escherichia coli minB and wild-type filaments. Jaffé, A., Boye, E., D'Ari, R. J. Bacteriol. (1990) [Pubmed]
  6. The pharmacokinetics of furazlocillin in healthy humans. Hinderling, P.H., Gundert-Remy, U., Förster, D., Gau, W. Journal of pharmacokinetics and biopharmaceutics. (1983) [Pubmed]
  7. Interactions of Yersinia pestis penicillin-binding proteins with beta-lactam antibiotics. Ferreira, R.C., Park, J.T., Camelo, D., De Almeida, D.F., Ferreira, L.C. Antimicrob. Agents Chemother. (1995) [Pubmed]
  8. Overview of acylureidopenicillin pharmacokinetics. Bergan, T. Scandinavian journal of infectious diseases. Supplementum. (1981) [Pubmed]
  9. Structural inhibition and reactivation of Escherichia coli septation by elements of the SOS and TER pathways. Dopazo, A., Tormo, A., Aldea, M., Vicente, M. J. Bacteriol. (1987) [Pubmed]
  10. Volume growth, murein synthesis, and murein cross-linkage during the division cycle of Escherichia coli PA3092. Olijhoek, A.J., Klencke, S., Pas, E., Nanninga, N., Schwarz, U. J. Bacteriol. (1982) [Pubmed]
  11. Rate and topography of peptidoglycan synthesis during cell division in Escherichia coli: concept of a leading edge. Wientjes, F.B., Nanninga, N. J. Bacteriol. (1989) [Pubmed]
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