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MeSH Review


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Disease relevance of Bacteriolysis


High impact information on Bacteriolysis

  • The time-course and dose dependency of bacteriolysis in the isolated system were identical to those in C4-depleted serum [5].
  • In vitro analyses using (125)I-CD59 and bacteriolysis assays showed that protectin bound to H. pylori and protected CagA(+) strains against complement killing [6].
  • Humoral IgA, separated and purified from human sera drawn 12, 27, and 33 days after infection with serogroups B, Y, and C meningococci, respectively, has been shown to inhibit complement-mediated bacteriolysis by IgG and IgM purified from the same sera [7].
  • Saturation of one or more PBPs also resulted in a different rate of bacteriolysis, the highest rate being obtained by the cefsulodin-mecillinam combination and by 5 micrograms of either imipenem or meropenem per ml [8].
  • Experiments were therefore undertaken to assess stimulation of human monocytes by components released from Escherichia coli following bacteriolysis by the cell wall-active antibiotic ceftazidime [9].

Chemical compound and disease context of Bacteriolysis


Anatomical context of Bacteriolysis

  • Neither an enhancement of autolytic wall degradation nor an inhibition of the incorporation of cell wall material are pre-requisites for penicillin-induced bacteriolysis in staphylococci [11].

Associations of Bacteriolysis with chemical compounds


Gene context of Bacteriolysis

  • Transmission electron microscopic studies revealed that FK037 inhibited septum formation and induced thick cross walls and bacteriolysis at the division sites in MRSA after 4 h incubation [16].
  • Overexpression of the emtA gene did not result in bacteriolysis in vivo, but the enzyme was shown to hydrolyze glycan strands isolated from murein by amidase treatment [17].
  • The two OS of a gonococcal strain sensitive to normal human serum (NHS) bacteriolysis (sers) varied in their ability to inhibit the binding of NHS immunoglobulin M to their parental LOS [18].
  • It is suggested that the augmented killing could be due to bacteriolysis by beta-glucuronidase [19].
  • Bacteriolysis induced by the antibiotic can be modulated by addition of EDTA, divalent cations and autolysin activators (trypsin) or inhibitors (cardiolipin), suggesting that topologic regulation of the autolysins is involved in the process [20].

Analytical, diagnostic and therapeutic context of Bacteriolysis


  1. Penicillin-binding protein inactivation by human neutrophil myeloperoxidase. Rakita, R.M., Rosen, H. J. Clin. Invest. (1991) [Pubmed]
  2. Complement-mediated bactericidal activity of human antibodies to poly alpha 2-->8 N-acetylneuraminic acid, the capsular polysaccharide of Neisseria meningitidis serogroup B. Mandrell, R.E., Azmi, F.H., Granoff, D.M. J. Infect. Dis. (1995) [Pubmed]
  3. Suppression of penicillin-induced lysis of Staphylococcus aureus by cibacron blue 3G-A. Sugai, M., Ooku, K., Akiyama, T., Inoue, S., Iseda, S., Miyake, Y., Suginaka, H. FEMS Microbiol. Lett. (1991) [Pubmed]
  4. Failure to trigger the autolytic enzymes in minicells of Escherichia coli. Markiewicz, Z., Höltje, J.V. FEMS Microbiol. Lett. (1992) [Pubmed]
  5. Bactericidal activity of the alternative complement pathway generated from 11 isolated plasma proteins. Schreiber, R.D., Morrison, D.C., Podack, E.R., Müller-Eberhard, H.J. J. Exp. Med. (1979) [Pubmed]
  6. Survival of Helicobacter pylori From complement lysis by binding of GPI-anchored protectin (CD59). Rautemaa, R., Rautelin, H., Puolakkainen, P., Kokkola, A., Kärkkäinen, P., Meri, S. Gastroenterology (2001) [Pubmed]
  7. Bactericidal activity of meningococcal antisera. Blocking by IgA of lytic antibody in human convalescent sera. Griffiss, J.M. J. Immunol. (1975) [Pubmed]
  8. Target for bacteriostatic and bactericidal activities of beta-lactam antibiotics against Escherichia coli resides in different penicillin-binding proteins. Satta, G., Cornaglia, G., Mazzariol, A., Golini, G., Valisena, S., Fontana, R. Antimicrob. Agents Chemother. (1995) [Pubmed]
  9. Evidence for lipopolysaccharide as the predominant proinflammatory mediator in supernatants of antibiotic-treated bacteria. Leeson, M.C., Fujihara, Y., Morrison, D.C. Infect. Immun. (1994) [Pubmed]
  10. Monobactam antibiotics in subinhibitory concentrations enhance opsonophagocytosis and serum bacteriolysis in certain Escherichia coli strains. Veringa, E., Box, A., Rozenberg-Arska, M., Verhoef, J. Drugs under experimental and clinical research. (1988) [Pubmed]
  11. Neither an enhancement of autolytic wall degradation nor an inhibition of the incorporation of cell wall material are pre-requisites for penicillin-induced bacteriolysis in staphylococci. Reinicke, B., Blümel, P., Labischinski, H., Giesbrecht, P. Arch. Microbiol. (1985) [Pubmed]
  12. A murein hydrolase is the specific target of bulgecin in Escherichia coli. Templin, M.F., Edwards, D.H., Höltje, J.V. J. Biol. Chem. (1992) [Pubmed]
  13. Surface action of gentamicin on Pseudomonas aeruginosa. Kadurugamuwa, J.L., Clarke, A.J., Beveridge, T.J. J. Bacteriol. (1993) [Pubmed]
  14. Antibody-mediated bacteriolysis: enhanced killing of cyclacillin-treated bacteria. Friedman, H., Warren, G.H. Proc. Soc. Exp. Biol. Med. (1976) [Pubmed]
  15. Onset of penicillin-induced bacteriolysis in staphylococci is cell cycle dependent. Maidhof, H., Johannsen, L., Labischinski, H., Giesbrecht, P. J. Bacteriol. (1989) [Pubmed]
  16. In vitro and in vivo antibacterial activities of FK037, a new parenteral cephalosporin. Nishino, T., Otsuki, M., Hatano, K., Nishihara, Y. Chemotherapy. (1994) [Pubmed]
  17. Membrane-bound lytic endotransglycosylase in Escherichia coli. Kraft, A.R., Templin, M.F., Höltje, J.V. J. Bacteriol. (1998) [Pubmed]
  18. Physical heterogeneity of neisserial lipooligosaccharides reflects oligosaccharides that differ in apparent molecular weight, chemical composition, and antigenic expression. Griffiss, J.M., O'Brien, J.P., Yamasaki, R., Williams, G.D., Rice, P.A., Schneider, H. Infect. Immun. (1987) [Pubmed]
  19. Synergism of cephalosporins at subinhibitory concentrations and polymorphonuclear leukocytes on phagocytic killing of Escherichia coli and its mode of action. Watanabe, Y., Tawara, S., Mine, Y., Kikuchi, H., Goto, S., Kuwahara, S. J. Antibiot. (1986) [Pubmed]
  20. Induction of autolysis in Enterococcus faecalis S-47 by peptide AS-48. Gálvez, A., Valdivia, E., Martínez-Bueno, M., Maqueda, M. J. Appl. Bacteriol. (1990) [Pubmed]
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