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Chemical Compound Review

AC1O5MZE     (2Z,4E,6E,8E)-3,7-dimethyl-9- (2,6,6...

Synonyms: LS-143474, Ro 22-6595, 71748-58-8, Oxoretinoic acid, 4-Oxoisotretinoin, ...
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Disease relevance of Oxoretinoic acid

  • Forty-eight hours later, cheilitis, diffuse cutaneous xerosis and desquamation of the forehead and of the external auditory meatus occurred; cutaneous xerosis and cheilitis resolved spontaneously, We determined the serum level of isotretinoin and of 4-oxo-isotretinoin, its natural metabolite in sera taken 4, 5, 6 and 11 days following ingestion [1].

High impact information on Oxoretinoic acid


Associations of Oxoretinoic acid with other chemical compounds


Analytical, diagnostic and therapeutic context of Oxoretinoic acid


  1. Massive isotretinoin intoxication. Aubin, S., Lorette, G., Muller, C., Vaillant, L. Clin. Exp. Dermatol. (1995) [Pubmed]
  2. In vitro and in vivo metabolism of all-trans- and 13-cis-retinoic acid in hamsters. Identification of 13-cis-4-oxoretinoic acid. Frolik, C.A., Roller, P.P., Roberts, A.B., Sporn, M.B. J. Biol. Chem. (1980) [Pubmed]
  3. Isotretinoin kinetics after 80 to 320 mg oral doses. Colburn, W.A., Gibson, D.M. Clin. Pharmacol. Ther. (1985) [Pubmed]
  4. Pharmacokinetics of retinoids in women after meal consumption or vitamin A supplementation. Chen, C., Mistry, G., Jensen, B., Heizmann, P., Timm, U., van Brummelen, P., Rakhit, A.K. Journal of clinical pharmacology. (1996) [Pubmed]
  5. Teratogenicity and placental transfer of all-trans-, 13-cis-, 4-oxo-all-trans-, and 4-oxo-13-cis-retinoic acid after administration of a low oral dose during organogenesis in mice. Creech Kraft, J., Löfberg, B., Chahoud, I., Bochert, G., Nau, H. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
  6. Pharmacokinetics of isotretinoin during repetitive dosing to patients. Brazzell, R.K., Vane, F.M., Ehmann, C.W., Colburn, W.A. Eur. J. Clin. Pharmacol. (1983) [Pubmed]
  7. Simultaneous analysis of retinol, all-trans- and 13-cis-retinoic acid and 13-cis-4-oxoretinoic acid in plasma by liquid chromatography using on-column concentration after single-phase fluid extraction. Teerlink, T., Copper, M.P., Klaassen, I., Braakhuis, B.J. J. Chromatogr. B Biomed. Sci. Appl. (1997) [Pubmed]
  8. Identification of 4-oxo-13-cis-retinoic acid as the major metabolite of 13-cis-retinoic acid in human blood. Vane, F.M., Buggé, C.J. Drug Metab. Dispos. (1981) [Pubmed]
  9. Pharmacokinetics of the retinoids isotretinoin and etretinate. A comparative review. Brazzell, R.K., Colburn, W.A. J. Am. Acad. Dermatol. (1982) [Pubmed]
  10. Developmental effects of isotretinoin and 4-oxo-isotretinoin: the role of metabolism in teratogenicity. Kochhar, D.M., Penner, J.D. Teratology (1987) [Pubmed]
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