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MeSH Review


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Disease relevance of Cheilitis


High impact information on Cheilitis

  • The only toxic effect of isotretinoin therapy was cheilitis in two patients [6].
  • In addition, retinoid-like manifestations such as cutaneous xerosis and cheilitis are frequent mucocutaneous adverse effects related to indinavir [7].
  • DESIGN: Follow-up study in 7 patients with severe persisting macrocheilia, including 3 patients with Melkersson-Rosenthal syndrome and 4 patients with cheilitis granulomatosa in a stable state of disease, treated by reduction cheiloplasty at our hospital between January 1, 1987, and December 31, 2002 [8].
  • Acitretin dose had to be reduced in most patients because of the frequent occurrence of mucocutaneous side effects, such as cheilitis, excessive peeling of the skin, and hair disorders [9].
  • No recurrences were seen among patients who received adjuvant treatment for actinic cheilitis with the carbon dioxide (CO2) laser, had clinical lesions 1 cm or less in diameter, or had post-MMS defects 2 cm or less in diameter [10].

Chemical compound and disease context of Cheilitis


Biological context of Cheilitis


Anatomical context of Cheilitis


Gene context of Cheilitis

  • Altered cytokeratin expression in actinic cheilitis [18].
  • Surgical treatment of persistent macrocheilia in patients with Melkersson-Rosenthal syndrome and cheilitis granulomatosa [8].
  • Cheilitis and cobalt allergy related to ingestion of vitamin B12 [19].
  • METHODS: Actinic cheilitis (n = 15) and normal lip (n = 8) biopsies were stained immunohistochemically for tryptase and enzymehistochemically for chymase to determine MC density and protease content [20].
  • The three most common mucosal changes not related to denture wearing were coated changes of the tongue (7%), angular cheilitis (6%) and varicose veins under the tongue (4%) [21].

Analytical, diagnostic and therapeutic context of Cheilitis


  1. Phase I evaluation of all-trans-retinoic acid in adults with solid tumors. Lee, J.S., Newman, R.A., Lippman, S.M., Huber, M.H., Minor, T., Raber, M.N., Krakoff, I.H., Hong, W.K. J. Clin. Oncol. (1993) [Pubmed]
  2. Side-effect profile of acitretin therapy in psoriasis. Gupta, A.K., Goldfarb, M.T., Ellis, C.N., Voorhees, J.J. J. Am. Acad. Dermatol. (1989) [Pubmed]
  3. Circumoral dermatitis and cheilitis caused by tartar control dentifrices. Beacham, B.E., Kurgansky, D., Gould, W.M. J. Am. Acad. Dermatol. (1990) [Pubmed]
  4. Orofacial granulomatosis in a patient with Crohn's disease. van de Scheur, M.R., van der Waal, R.I., Völker-Dieben, H.J., Klinkenberg-Knol, E.C., Starink, T.M., van der Waal, I. J. Am. Acad. Dermatol. (2003) [Pubmed]
  5. Risk factors associated with oral lesions in HIV-infected heterosexual people and intravenous drug users in Thailand. Nittayananta, W., Chanowanna, N., Sripatanakul, S., Winn, T. J. Oral Pathol. Med. (2001) [Pubmed]
  6. A pilot study of isotretinoin in the treatment of juvenile chronic myelogenous leukemia. Castleberry, R.P., Emanuel, P.D., Zuckerman, K.S., Cohn, S., Strauss, L., Byrd, R.L., Homans, A., Chaffee, S., Nitschke, R., Gualtieri, R.J. N. Engl. J. Med. (1994) [Pubmed]
  7. Indinavir-induced retinoid-like effects: incidence, clinical features and management. García-Silva, J., Almagro, M., Peña-Penabad, C., Fonseca, E. Drug safety : an international journal of medical toxicology and drug experience. (2002) [Pubmed]
  8. Surgical treatment of persistent macrocheilia in patients with Melkersson-Rosenthal syndrome and cheilitis granulomatosa. Kruse-Lösler, B., Presser, D., Metze, D., Joos, U. Archives of dermatology. (2005) [Pubmed]
  9. Acitretin treatment of premalignant and malignant skin disorders in renal transplant recipients: clinical effects of a randomized trial comparing two doses of acitretin. de Sévaux, R.G., Smit, J.V., de Jong, E.M., van de Kerkhof, P.C., Hoitsma, A.J. J. Am. Acad. Dermatol. (2003) [Pubmed]
  10. Squamous cell carcinoma of the lip treated with Mohs micrographic surgery: outcome at 5 years. Holmkvist, K.A., Roenigk, R.K. J. Am. Acad. Dermatol. (1998) [Pubmed]
  11. Carbon dioxide laser treatment of actinic cheilitis. Clinicohistopathologic correlation to determine the optimal depth of destruction. Johnson, T.M., Sebastien, T.S., Lowe, L., Nelson, B.R. J. Am. Acad. Dermatol. (1992) [Pubmed]
  12. Microscopically proven cure of actinic cheilitis by CO2 laser. Whitaker, D.C. Lasers in surgery and medicine. (1987) [Pubmed]
  13. Treatment of recalcitrant cheilitis granulomatosa with metronidazole. Kano, Y., Shiohara, T., Yagita, A., Nagashima, M. J. Am. Acad. Dermatol. (1992) [Pubmed]
  14. Cheilitis granulomatosa. Successful treatment with combined local triamcinolone injections and surgery. Krutchkoff, D., James, R. Archives of dermatology. (1978) [Pubmed]
  15. Photodynamic therapy with 5-aminolevulinic acid in the treatment of actinic cheilitis. Stender, I.M., Wulf, H.C. Br. J. Dermatol. (1996) [Pubmed]
  16. Cheilitis granulomatosa: overview of 13 patients with long-term follow-up--results of management. van der Waal, R.I., Schulten, E.A., van der Meij, E.H., van de Scheur, M.R., Starink, T.M., van der Waal, I. International journal of dermatology. (2002) [Pubmed]
  17. Adjuvant treatment with a vitamin A analogue (etretinate) after transurethral resection of superficial bladder tumors. Final analysis of a prospective, randomized multicenter trial in Switzerland. Studer, U.E., Jenzer, S., Biedermann, C., Chollet, D., Kraft, R., von Toggenburg, H., Vonbank, F. Eur. Urol. (1995) [Pubmed]
  18. Altered cytokeratin expression in actinic cheilitis. dos Santos, J.N., de Sousa, S.O., Nunes, F.D., Sotto, M.N., de Araújo, V.C. J. Cutan. Pathol. (2003) [Pubmed]
  19. Cheilitis and cobalt allergy related to ingestion of vitamin B12. Price, M.L., MacDonald, D.M. Contact Derm. (1981) [Pubmed]
  20. Increased mast cell density and protease content in actinic cheilitis. Rojas, I.G., Martínez, A., Pineda, A., Spencer, M.L., Jiménez, M., Rudolph, M.I. J. Oral Pathol. Med. (2004) [Pubmed]
  21. Oral mucosal lesions and oral hygiene habits in the home-living elderly. Nevalainen, M.J., Närhi, T.O., Ainamo, A. Journal of oral rehabilitation. (1997) [Pubmed]
  22. Allergic contact cheilitis due to effervescent dental cleanser: combined responsibilities of the allergen persulfate and prosthesis porosity. Le Coz, C.J., Bezard, M. Contact Derm. (1999) [Pubmed]
  23. Kveim test reactivity in Melkersson-Rosenthal syndrome (cheilitis granulomatosa). Lindelöf, B., Eklund, A., Lidén, S. Acta Derm. Venereol. (1985) [Pubmed]
  24. Carbon dioxide laser vermilionectomy for actinic cheilitis. Alamillos-Granados, F.J., Naval-Gías, L., Dean-Ferrer, A., Alonso del Hoyo, J.R. J. Oral Maxillofac. Surg. (1993) [Pubmed]
  25. Nonmelanoma skin cancer. Risks, treatment options, and tips on prevention. Kibarian, M.A., Hruza, G.J. Postgraduate medicine. (1995) [Pubmed]
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