Disease relevance of Cheilitis

• Toxicities included cheilitis, skin reactions, headache, and nausea and vomiting, as well as transient elevations of liver enzymes and triglyceride levels [1].
• They were similar to those of etretinate therapy; cheilitis, peeling of palms and soles, and alopecia occurred most frequently [2].
• Circumoral dermatitis and cheilitis caused by tartar control dentifrices [3].
• Orofacial granulomatosis encompasses the previously recognized clinical entities Melkersson-Rosenthal syndrome and cheilitis granulomatosa [4].
• Oral candidiasis was the most common oral lesion among HIV-infected individuals (39.6%), followed by hairy leukoplakia (HL) (26.3%), exfoliative cheilitis (18.3%), and linear gingival erythema (LGE) (11.5%) [5].

High impact information on Cheilitis

• The only toxic effect of isotretinoin therapy was cheilitis in two patients [6].
• In addition, retinoid-like manifestations such as cutaneous xerosis and cheilitis are frequent mucocutaneous adverse effects related to indinavir [7].
• DESIGN: Follow-up study in 7 patients with severe persisting macrocheilia, including 3 patients with Melkersson-Rosenthal syndrome and 4 patients with cheilitis granulomatosa in a stable state of disease, treated by reduction cheiloplasty at our hospital between January 1, 1987, and December 31, 2002 [8].
• Acitretin dose had to be reduced in most patients because of the frequent occurrence of mucocutaneous side effects, such as cheilitis, excessive peeling of the skin, and hair disorders [9].
• No recurrences were seen among patients who received adjuvant treatment for actinic cheilitis with the carbon dioxide (CO2) laser, had clinical lesions 1 cm or less in diameter, or had post-MMS defects 2 cm or less in diameter [10].

Chemical compound and disease context of Cheilitis

• Carbon dioxide laser treatment of actinic cheilitis. Clinicohistopathologic correlation to determine the optimal depth of destruction [11].
• Microscopically proven cure of actinic cheilitis by CO2 laser [12].
• Treatment of recalcitrant cheilitis granulomatosa with metronidazole [13].
• Cheilitis granulomatosa. Successful treatment with combined local triamcinolone injections and surgery [14].
• Photodynamic therapy with 5-aminolevulinic acid in the treatment of actinic cheilitis [15].

Biological context of Cheilitis

• Although a relationship has been proposed between Melkersson-Rosenthal syndrome (and the monosymptomatic form, cheilitis granulomatosa) and Crohn's disease on the basis of the orofacial swelling and similar histology, several studies of Melkersson-Rosenthal syndrome have not found an association with Crohn's disease [16].

Anatomical context of Cheilitis

• The side effects of etretinate (cheilitis, dryness of mucous membranes and skin) were acceptable to most patients [17].

Gene context of Cheilitis

• Altered cytokeratin expression in actinic cheilitis [18].
• Surgical treatment of persistent macrocheilia in patients with Melkersson-Rosenthal syndrome and cheilitis granulomatosa [8].
• Cheilitis and cobalt allergy related to ingestion of vitamin B12 [19].
• METHODS: Actinic cheilitis (n = 15) and normal lip (n = 8) biopsies were stained immunohistochemically for tryptase and enzymehistochemically for chymase to determine MC density and protease content [20].
• The three most common mucosal changes not related to denture wearing were coated changes of the tongue (7%), angular cheilitis (6%) and varicose veins under the tongue (4%) [21].

Analytical, diagnostic and therapeutic context of Cheilitis

• Cleansing agents, adsorbed on tartar and porous resins of worn dental prostheses, should be considered as potential sensitizers and consequently patch tested on such patients with chronic cheilitis [22].
• Allergic contact cheilitis due to effervescent dental cleanser: combined responsibilities of the allergen persulfate and prosthesis porosity [22].
• Kveim test reactivity in Melkersson-Rosenthal syndrome (cheilitis granulomatosa) [23].
• Because it has the advantages of both scalpel vermilionectomy and laser vaporization of the vermilion, CO2 laser vermilionectomy is proposed as a good method of treating actinic cheilitis [24].
• Premalignant actinic keratoses are treated with cryosurgery; the CO2 laser is the treatment of choice for actinic cheilitis [25].

References