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Chemical Compound Review

Midafotee     4-[(E)-3-phosphonoprop-2- enyl]piperazine-2...

Synonyms: Cppene, CHEMBL224678, SureCN726553, LS-172816, LS-172991, ...
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Disease relevance of D-Cpp-ene


High impact information on D-Cpp-ene


Gene context of D-Cpp-ene

  • The present study sought to evaluate the analgesic potency of combined administration of morphine (5-20 mg/kg) and a competitive NMDA receptor antagonist D-CPPene (SDZ EAA 494; 3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid; 0.3-5.6 mg/kg) in the tail-flick and tail-pinch tests with rats [5].


  1. Focal ischemic damage is reduced by CPP-ene studies in two animal models. Bullock, R., McCulloch, J., Graham, D.I., Lowe, D., Chen, M.H., Teasdale, G.M. Stroke (1990) [Pubmed]
  2. The pharmacology of SDZ EAA 494, a competitive NMDA antagonist. Lowe, D.A., Emre, M., Frey, P., Kelly, P.H., Malanowski, J., McAllister, K.H., Neijt, H.C., Rüdeberg, C., Urwyler, S., White, T.G. Neurochem. Int. (1994) [Pubmed]
  3. Electrical but not chemical kindling increases sensitivity to some phencyclidine-like behavioral effects induced by the competitive NMDA receptor antagonist D-CPPene in rats. Wlaź, P., Ebert, U., Potschka, H., Löscher, W. Eur. J. Pharmacol. (1998) [Pubmed]
  4. Focal cerebral ischemia in the cat: pretreatment with a competitive NMDA receptor antagonist, D-CPP-ene. Bullock, R., Graham, D.I., Chen, M.H., Lowe, D., McCulloch, J. J. Cereb. Blood Flow Metab. (1990) [Pubmed]
  5. Prolongation of morphine analgesia by competitive NMDA receptor antagonist D-CPPene (SDZ EAA 494) in rats. Bespalov, A., Kudryashova, M., Zvartau, E. Eur. J. Pharmacol. (1998) [Pubmed]
  6. The excitatory amino acid antagonist D-CPP-ene (SDZ EAA-494) in patients with epilepsy. Sveinbjornsdottir, S., Sander, J.W., Upton, D., Thompson, P.J., Patsalos, P.N., Hirt, D., Emre, M., Lowe, D., Duncan, J.S. Epilepsy Res. (1993) [Pubmed]
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