Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Midafotee 4-[(E)-3-phosphonoprop-2- enyl]piperazine-2...

Synonyms: Cppene, CHEMBL224678, SureCN726553, LS-172816, LS-172991, ...

Bespalov, A. et al., Wlaź, P. et al., Bullock, R. et al., Lowe, D.A. et al., Bullock, R. et al., et al.

Bespalov, Kudryashova, Zvartau,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of D-Cpp-ene

We have studied a new high-affinity competitive N-methyl-D-aspartate antagonist, D-CPP-ene (SDZ-EAA 494), in two models of focal cerebral ischemia [1].
The anti-ischaemic action of SDZ EAA 494 encourages further testing in brain trauma, in which the anticonvulsant action of the compound may be an added benefit [2].
From these data we predicted that epileptic patients may exhibit a hypersensitivity to PCP-like adverse effects of competitive NMDA receptor antagonists, which was subsequently confirmed in a clinical trial with D-CPPene (SDZ EAA-494; 3-(2-carboxypiperazine-4-yl)propenyl-1-phosphonate) [3].

High impact information on D-Cpp-ene

The effects of the competitive N-methyl-D-aspartate (NMDA) receptor antagonist D-(E)-4-(3-phosphonoprop-2-enyl)piperazine-2-carboxylic acid (D-CPP-ene; SDZ EAA 494) upon ischemic brain damage have been examined in anesthetized cats [4].
Prolongation of morphine analgesia by competitive NMDA receptor antagonist D-CPPene (SDZ EAA 494) in rats [5].
The excitatory amino acid antagonist D-CPP-ene (SDZ EAA-494) in patients with epilepsy [6].

Gene context of D-Cpp-ene

The present study sought to evaluate the analgesic potency of combined administration of morphine (5-20 mg/kg) and a competitive NMDA receptor antagonist D-CPPene (SDZ EAA 494; 3-(2-carboxypiperazin-4-yl)-1-propenyl-1-phosphonic acid; 0.3-5.6 mg/kg) in the tail-flick and tail-pinch tests with rats [5].

References

Focal ischemic damage is reduced by CPP-ene studies in two animal models. Bullock, R., McCulloch, J., Graham, D.I., Lowe, D., Chen, M.H., Teasdale, G.M. Stroke (1990) [Pubmed]
The pharmacology of SDZ EAA 494, a competitive NMDA antagonist. Lowe, D.A., Emre, M., Frey, P., Kelly, P.H., Malanowski, J., McAllister, K.H., Neijt, H.C., Rüdeberg, C., Urwyler, S., White, T.G. Neurochem. Int. (1994) [Pubmed]
Electrical but not chemical kindling increases sensitivity to some phencyclidine-like behavioral effects induced by the competitive NMDA receptor antagonist D-CPPene in rats. Wlaź, P., Ebert, U., Potschka, H., Löscher, W. Eur. J. Pharmacol. (1998) [Pubmed]
Focal cerebral ischemia in the cat: pretreatment with a competitive NMDA receptor antagonist, D-CPP-ene. Bullock, R., Graham, D.I., Chen, M.H., Lowe, D., McCulloch, J. J. Cereb. Blood Flow Metab. (1990) [Pubmed]
Prolongation of morphine analgesia by competitive NMDA receptor antagonist D-CPPene (SDZ EAA 494) in rats. Bespalov, A., Kudryashova, M., Zvartau, E. Eur. J. Pharmacol. (1998) [Pubmed]
The excitatory amino acid antagonist D-CPP-ene (SDZ EAA-494) in patients with epilepsy. Sveinbjornsdottir, S., Sander, J.W., Upton, D., Thompson, P.J., Patsalos, P.N., Hirt, D., Emre, M., Lowe, D., Duncan, J.S. Epilepsy Res. (1993) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.