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Chemical Compound Review:

DCVAC (2S)-2-acetamido-3-[(E)-1,2...

Synonyms: N-Acetyl-dcvc, CHEMBL2075003, AC1O5P5G, 104713-70-4, N-Acetyl(1,2-dichloroviny)cysteine, ...

Wolfgang, G.H. et al., Kanhai, W. et al.

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Disease relevance of N-Acetyl-dcvc

AOAA also partially inhibited the toxicity of DCVC and N-acetyl-DCVC as determined by intracellular K+ content, lactate dehydrogenase activity, and histopathology [1].

High impact information on N-Acetyl-dcvc

N-Acetyl-DCVC was shown to be transported via the organic anion system by its ability to inhibit PAH transport by the cells and the ability of probenecid to decrease uptake (80%) and toxicity of N-acetyl-DCVC [1].
Biliary cannulation did not influence the renal excretion of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine, indicating that glutathione conjugate formation occurs in the kidney [2].

Chemical compound and disease context of N-Acetyl-dcvc

Renal cortical slices were used to determine the toxicity of N-acetyl-S-(1,2-dichlorovinyl)-L-cysteine (N-acetyl-DCVC) as well as to investigate the transport and metabolism of S-(1,2-dichlorovinyl)-L-cysteine (DCVC) and the N-acetyl derivative [1].

References

N-acetyl S-(1,2-dichlorovinyl)-L-cysteine produces a similar toxicity to S-(1,2-dichlorovinyl)-L-cysteine in rabbit renal slices: differential transport and metabolism. Wolfgang, G.H., Gandolfi, A.J., Stevens, J.L., Brendel, K. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
Metabolism of 14C-dichloroethyne in rats. Kanhai, W., Koob, M., Dekant, W., Henschler, D. Xenobiotica (1991) [Pubmed]

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