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Chemical Compound Review:

D-myo-PI[5]P [(1S,2R,3R,4R,5R,6R)-3- [[(2R)-2,3...

Synonyms: PtdIns(5)P, PI5P, AG-L-65915, P1168_SIGMA, CTK8G0702, ...

Di Lello, P. et al., Pendaries, C. et al., Mason, D. et al.

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Disease relevance of dipalmitoylphosphoinositol

The virulence factor IpgD, delivered into nonphagocytic cells by the type III secretion system of the pathogen Shigella flexneri, is a phosphoinositide 4-phosphatase generating phosphatidylinositol 5 monophosphate (PtdIns5P) [1].
Here we report that SigD, a phosphatase derived from Salmonella, can effectively hydrolyze PtdIns(4,5)P(2), generating PtdIns(5)P [2].

High impact information on dipalmitoylphosphoinositol

NMR chemical shift mapping demonstrated that the PtdIns(5)P binding site on Tfb1 (p62) is located in the basic pocket formed by beta-strands beta5-beta7 of the PH domain fold [3].
Interestingly, the structural composition of the PtdIns(5)P binding site is different from the composition of the binding sites for phosphoinositides on prototypic PH domains [3].

Associations of dipalmitoylphosphoinositol with other chemical compounds

In addition, we have performed in vitro binding studies that demonstrate that the PH domains of Tfb1 and p62 specifically bind to monophosphorylated inositides [PtdIns(5)P and PtdIns(3)P] [3].

References

PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. Pendaries, C., Tronchère, H., Arbibe, L., Mounier, J., Gozani, O., Cantley, L., Fry, M.J., Gaits-Iacovoni, F., Sansonetti, P.J., Payrastre, B. EMBO J. (2006) [Pubmed]
Alteration of Epithelial Structure and Function Associated with PtdIns(4,5)P2 Degradation by a Bacterial Phosphatase. Mason, D., Mallo, G.V., Terebiznik, M.R., Payrastre, B., Finlay, B.B., Brumell, J.H., Rameh, L., Grinstein, S. J. Gen. Physiol. (2007) [Pubmed]
NMR structure of the amino-terminal domain from the Tfb1 subunit of TFIIH and characterization of its phosphoinositide and VP16 binding sites. Di Lello, P., Nguyen, B.D., Jones, T.N., Potempa, K., Kobor, M.S., Legault, P., Omichinski, J.G. Biochemistry (2005) [Pubmed]

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