Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Circulase butyl7-[(4R,5S)-2- butanoyloxy-4-hydroxy-5...

Synonyms: Ecraprost, SureCN1650052, AC1O5VMW, AS 013, 136892-64-3, ...

Hokamura, K. et al., Tsagris, M. et al., Belch, J.J. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Circulase

METHODS AND RESULTS: Eighty patients with stenosis or occlusion, symptoms of intermittent claudication, and maximum walking distance of > or = 30 and < or = 300 m on a standard treadmill test were randomized to placebo or one of three dosage regimens of AS-013 [1].
Effect of lipo-pro-prostaglandin E1, AS-013 on rat inner ear microcirculatory thrombosis [2].

High impact information on Circulase

The new finding that RNase T1 acts as an RNA processing enzyme and, in particular, as an RNA 'circulase' can be explained by the unique structural preconditions inherent in the viroid-specific substrate and by the well characterized two-step cleavage mechanism of the enzyme [3].
We investigated effects of lipo-pro-prostaglandin E1 (lipo-[11alpha, 13E, 15S]-11,15-dihydroxy-9-[1-oxobutoxy]-prosta-8, 13-dien-1-oic acid butyl ester), AS-013 in two models of hearing disturbance and equilibrium dysfunction induced by rat inner ear microcirculatory thrombosis [2].
AS-013 significantly (P<0.05) prolonged time to disappearance of the action potential compared with control group [2].

Anatomical context of Circulase

These results suggest that lipo-pro-prostaglandin E1, AS-013 may prevent hearing disturbance and equilibrium dysfunction due to inner ear microcirculatory disorders [2].

References

Randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of AS-013, a prostaglandin E1 prodrug, in patients with intermittent claudication. Belch, J.J., Bell, P.R., Creissen, D., Dormandy, J.A., Kester, R.C., McCollum, R.D., Mizushima, Y., Ruckley, C.V., Scurr, J.H., Wolfe, J.H. Circulation (1997) [Pubmed]
Effect of lipo-pro-prostaglandin E1, AS-013 on rat inner ear microcirculatory thrombosis. Hokamura, K., Umemura, K., Nakamura, N., Watanabe, M., Takashima, T., Nakashima, M. Prostaglandins Leukot. Essent. Fatty Acids (1998) [Pubmed]
Ribonuclease T1 generates circular RNA molecules from viroid-specific RNA transcripts by cleavage and intramolecular ligation. Tsagris, M., Tabler, M., Sänger, H.L. Nucleic Acids Res. (1991) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.