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MeSH Review

Exercise Test

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Disease relevance of Exercise Test


Psychiatry related information on Exercise Test


High impact information on Exercise Test

  • In the first part of the study, we performed treadmill exercise tests in 10 patients (group 1) at a constant maximal workload to assess the effects of 10 mg of inhaled methoxamine on the duration of exercise (a measure of endurance) [11].
  • On each test day, subjects performed two symptom-limited incremental exercise tests on a treadmill; the tests were separated by a recovery period and 50 to 70 minutes of exposure to either room air or air containing one of two concentrations of carbon monoxide (117 +/- 4.4 ppm or 253 +/- 6.1 ppm) [12].
  • We studied the value of thallium imaging as compared with clinical and exercise-test variables in predicting cardiac events occurring over five years in 525 consecutive patients referred for thallium-exercise testing in 1979 [13].
  • Six healthy subjects were given maximal exercise stress tests under three conditions: with no medication (control), during beta-blockade with propranolol, and during alpha-blockade with phentolamine [14].
  • INTERVENTIONS: All patients underwent 2 symptom-limited supine bicycle echocardiograms separated by an interval of 1 to 3 days after receiving a single dose of sildenafil (50 or 100 mg) or placebo 1 hour before each exercise test [15].

Chemical compound and disease context of Exercise Test


Biological context of Exercise Test


Anatomical context of Exercise Test


Associations of Exercise Test with chemical compounds


Gene context of Exercise Test

  • CFS patients did have a marginally reduced suppression of IGFBP-1 during the insulin stress test [36].
  • No evidence of insulin-like growth factor-binding protein 3 proteolysis during a maximal exercise test in elite athletes [37].
  • Net release rates of t-PA roughly doubled in response to the stress test (0.4 to 0.8 and 0.2 to 0.5 ng x min(-1) x 100 ml(-1) for t-PA antigen and activity, respectively, p <0.05 for both) [38].
  • Although the different sympathetic stimuli (90 degrees tilting, handgrip, treadmill test, bicycle test) caused a significant increase of the plasma epinephrine (E) and norepinephrine (NE) levels, they did not modify the beta-TG and PF4 levels in any of the groups studied [39].
  • During a maximal exercise test in 39 LQT1 patients carrying an identical KCNQ1 mutation (G589D) and showing a prolonged QT interval (>440 ms), QT intervals were longer in patients carrying the 897T allele than in those homozygous for the 897K allele [40].

Analytical, diagnostic and therapeutic context of Exercise Test


  1. Predictors of reinfarction and sudden death in a high-risk group of acute myocardial infarction survivors. Hunt, D., Baker, G., Hamer, A., Penington, C., Duffield, A., Sloman, G. Lancet (1979) [Pubmed]
  2. Cardiac rupture during dobutamine stress test. Reisenhofer, B., Squarcini, G., Picano, E. Ann. Intern. Med. (1998) [Pubmed]
  3. Efficacy of mibefradil compared with amlodipine in suppressing exercise-induced and daily silent ischemia: results of a multicenter, placebo-controlled trial. Tzivoni, D., Kadr, H., Braat, S., Rutsch, W., Ramires, J.A., Kobrin, I. Circulation (1997) [Pubmed]
  4. Effects of treatment on outcome in mildly symptomatic patients with ischemia during daily life. The Atenolol Silent Ischemia Study (ASIST). Pepine, C.J., Cohn, P.F., Deedwania, P.C., Gibson, R.S., Handberg, E., Hill, J.A., Miller, E., Marks, R.G., Thadani, U. Circulation (1994) [Pubmed]
  5. Acute anti-ischemic effect of testosterone in men with coronary artery disease. Rosano, G.M., Leonardo, F., Pagnotta, P., Pelliccia, F., Panina, G., Cerquetani, E., della Monica, P.L., Bonfigli, B., Volpe, M., Chierchia, S.L. Circulation (1999) [Pubmed]
  6. GABRA6 gene polymorphism and an attenuated stress response. Uhart, M., McCaul, M.E., Oswald, L.M., Choi, L., Wand, G.S. Mol. Psychiatry (2004) [Pubmed]
  7. Effects of sildenafil on cardiopulmonary responses during stress. Stanopoulos, I., Hatzichristou, D., Tryfon, S., Tzortzis, V., Apostolidis, A., Argyropoulou, P. J. Urol. (2003) [Pubmed]
  8. Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. Nakamura, K., Kurasawa, M. Eur. J. Pharmacol. (2001) [Pubmed]
  9. Psychological factors in silent myocardial ischemia. Freedland, K.E., Carney, R.M., Krone, R.J., Smith, L.J., Rich, M.W., Eisenkramer, G., Fischer, K.C. Psychosomatic medicine. (1991) [Pubmed]
  10. Correlations between event-related potential components and nitric oxide in maximal anaerobic exercise among sportsmen trained at various levels. Duzova, H., Ozişik, H.I., Polat, A., Emre, M.H., Gullu, E. Int. J. Neurosci. (2005) [Pubmed]
  11. Improvement in exercise performance by inhalation of methoxamine in patients with impaired left ventricular function. Cabanes, L., Costes, F., Weber, S., Regnard, J., Benvenuti, C., Castaigne, A., Guerin, F., Lockhart, A. N. Engl. J. Med. (1992) [Pubmed]
  12. Short-term effects of carbon monoxide exposure on the exercise performance of subjects with coronary artery disease. Allred, E.N., Bleecker, E.R., Chaitman, B.R., Dahms, T.E., Gottlieb, S.O., Hackney, J.D., Pagano, M., Selvester, R.H., Walden, S.M., Warren, J. N. Engl. J. Med. (1989) [Pubmed]
  13. Prognostic importance of thallium uptake by the lungs during exercise in coronary artery disease. Gill, J.B., Ruddy, T.D., Newell, J.B., Finkelstein, D.M., Strauss, H.W., Boucher, C.A. N. Engl. J. Med. (1987) [Pubmed]
  14. Catecholamine modulation of rapid potassium shifts during exercise. Williams, M.E., Gervino, E.V., Rosa, R.M., Landsberg, L., Young, J.B., Silva, P., Epstein, F.H. N. Engl. J. Med. (1985) [Pubmed]
  15. Cardiovascular effects of sildenafil during exercise in men with known or probable coronary artery disease: a randomized crossover trial. Arruda-Olson, A.M., Mahoney, D.W., Nehra, A., Leckel, M., Pellikka, P.A. JAMA (2002) [Pubmed]
  16. Prognostic utility of the exercise thallium-201 test in ambulatory patients with chest pain: comparison with cardiac catheterization. Kaul, S., Lilly, D.R., Gascho, J.A., Watson, D.D., Gibson, R.S., Oliner, C.A., Ryan, J.M., Beller, G.A. Circulation (1988) [Pubmed]
  17. Dobutamine-atropine stress echocardiography and clinical data for predicting late cardiac events in patients with suspected coronary artery disease. Poldermans, D., Fioretti, P.M., Boersma, E., Cornel, J.H., Borst, F., Vermeulen, E.G., Arnese, M., el-Hendy, A., Roelandt, J.R. Am. J. Med. (1994) [Pubmed]
  18. Clinical efficacy of sildenafil in primary pulmonary hypertension: a randomized, placebo-controlled, double-blind, crossover study. Sastry, B.K., Narasimhan, C., Reddy, N.K., Raju, B.S. J. Am. Coll. Cardiol. (2004) [Pubmed]
  19. Improved exercise capacity with acute aminophylline administration in patients with syndrome X. Emdin, M., Picano, E., Lattanzi, F., L'Abbate, A. J. Am. Coll. Cardiol. (1989) [Pubmed]
  20. Endurance testing for evaluation of antianginal therapy with amlodipine, a calcium channel blocking agent. Kinnard, D.R., Harris, M., Hossack, K.F. J. Am. Coll. Cardiol. (1988) [Pubmed]
  21. Energy expenditure with indoor exercise machines. Zeni, A.I., Hoffman, M.D., Clifford, P.S. JAMA (1996) [Pubmed]
  22. Anabolic effects of nandrolone decanoate in patients receiving dialysis: a randomized controlled trial. Johansen, K.L., Mulligan, K., Schambelan, M. JAMA (1999) [Pubmed]
  23. Transmyocardial laser revascularisation compared with continued medical therapy for treatment of refractory angina pectoris: a prospective randomised trial. ATLANTIC Investigators. Angina Treatments-Lasers and Normal Therapies in Comparison. Burkhoff, D., Schmidt, S., Schulman, S.P., Myers, J., Resar, J., Becker, L.C., Weiss, J., Jones, J.W. Lancet (1999) [Pubmed]
  24. Black-white differences in exercise blood pressure. The Lipid Research Clinics Program Prevalence Study. Ekelund, L.G., Suchindran, C.M., Karon, J.M., McMahon, R.P., Tyroler, H.A. Circulation (1990) [Pubmed]
  25. The diagnostic and prognostic significance of an asymptomatic positive exercise test. Weiner, D.A. Circulation (1987) [Pubmed]
  26. Influence of autonomic nervous system dysfunction on the development of type 2 diabetes: the CARDIA study. Carnethon, M.R., Jacobs, D.R., Sidney, S., Liu, K. Diabetes Care (2003) [Pubmed]
  27. Adrenergic regulation of human adipose tissue metabolism in situ during mental stress. Hagström-Toft, E., Arner, P., Wahrenberg, H., Wennlund, A., Ungerstedt, U., Bolinder, J. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  28. Comparison of DDD and 'VVI-R like' pacing during moderate exercise: echo-Doppler study. Lascault, G., Frank, R., Iwa, T., Girodo, S., Fontaine, G., Grosgogeat, Y. Eur. Heart J. (1992) [Pubmed]
  29. Quantitative myocardial mapping of perfusion and metabolism using parametric polar map displays in cardiac PET. Blanksma, P.K., Willemsen, A.T., Meeder, J.G., de Jong, R.M., Anthonio, R.L., Pruim, J., Vaalburg, W., Lie, K.I. J. Nucl. Med. (1995) [Pubmed]
  30. Syndrome X and endothelial dysfunction. Bellamy, M.F., Goodfellow, J., Tweddel, A.C., Dunstan, F.D., Lewis, M.J., Henderson, A.H. Cardiovasc. Res. (1998) [Pubmed]
  31. The hazards of bedside Bayes. Harris, J.M. JAMA (1981) [Pubmed]
  32. Vascular endothelial dysfunction resulting from L-arginine deficiency in a patient with lysinuric protein intolerance. Kamada, Y., Nagaretani, H., Tamura, S., Ohama, T., Maruyama, T., Hiraoka, H., Yamashita, S., Yamada, A., Kiso, S., Inui, Y., Ito, N., Kayanoki, Y., Kawata, S., Matsuzawa, Y. J. Clin. Invest. (2001) [Pubmed]
  33. Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial. Cleare, A.J., Heap, E., Malhi, G.S., Wessely, S., O'Keane, V., Miell, J. Lancet (1999) [Pubmed]
  34. Noradrenergic activity and silent ischaemia in hypertensive patients with stable angina: effect of metoprolol. Lee, D.D., Kimura, S., DeQuattro, V. Lancet (1989) [Pubmed]
  35. Verapamil in chronic stable angina. A controlled study with computerized multistage treadmill exercise. Subramanian, V.B., Lahiri, A., Paramasivan, R., Raftery, E.B. Lancet (1980) [Pubmed]
  36. Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome. Cleare, A.J., Sookdeo, S.S., Jones, J., O'Keane, V., Miell, J.P. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  37. No evidence of insulin-like growth factor-binding protein 3 proteolysis during a maximal exercise test in elite athletes. Dall, R., Lange, K.H., Kjaer, M., Jørgensen, J.O., Christiansen, J.S., Orskov, H., Flyvbjerg, A. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  38. Sympathoadrenal activation and muscarinic receptor stimulation induce acute release of tissue-type plasminogen activator but not von Willebrand factor across the human forearm. Jern, C., Selin, L., Tengborn, L., Jern, S. Thromb. Haemost. (1997) [Pubmed]
  39. Beta-TG and plasma catecholamines levels after sympathetic stimuli in hypertensives and patients with peripheral vascular disease. Catalano, M., Russo, U., Belletti, S., Colombo, F., Belloni, A., del Rosso, G., Lombardi, F., Libretti, A. Thromb. Haemost. (1990) [Pubmed]
  40. Functional characterization of the common amino acid 897 polymorphism of the cardiac potassium channel KCNH2 (HERG). Paavonen, K.J., Chapman, H., Laitinen, P.J., Fodstad, H., Piippo, K., Swan, H., Toivonen, L., Viitasalo, M., Kontula, K., Pasternack, M. Cardiovasc. Res. (2003) [Pubmed]
  41. Exercise testing in patients with variant angina: results, correlation with clinical and angiographic features and prognostic significance. Waters, D.D., Szlachcic, J., Bourassa, M.G., Scholl, J.M., Théroux, P. Circulation (1982) [Pubmed]
  42. Noninvasive diagnosis of coronary artery disease: the cardiokymographic stress test. Silverberg, R.A., Diamond, G.A., Vas, R., Tzivoni, D., Swan, H.J., Forrester, J.S. Circulation (1980) [Pubmed]
  43. Comparison of propranolol, diltiazem, and nifedipine in the treatment of ambulatory ischemia in patients with stable angina. Differential effects on ambulatory ischemia, exercise performance, and anginal symptoms. The ASIS Study Group. Stone, P.H., Gibson, R.S., Glasser, S.P., DeWood, M.A., Parker, J.D., Kawanishi, D.T., Crawford, M.H., Messineo, F.C., Shook, T.L., Raby, K. Circulation (1990) [Pubmed]
  44. Prediction of long-term clinical outcome with final translesional pressure gradient during coronary angioplasty. Hodgson, J.M., Reinert, S., Most, A.S., Williams, D.O. Circulation (1986) [Pubmed]
  45. Improvement of the age-related impairment in left ventricular diastolic filling with verapamil in the normal human heart. Arrighi, J.A., Dilsizian, V., Perrone-Filardi, P., Diodati, J.G., Bacharach, S.L., Bonow, R.O. Circulation (1994) [Pubmed]
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