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Chemical Compound Review:

Iralukast 7-[(2S,3E,5Z)-10-(4-ethanoyl- 3-hydroxy-2...

Synonyms: AC1O637I, 151581-24-7, Iralukast [INN], UNII-L1E28E0J8F

Majumdar, T.K. et al., Colussi, D. et al., Wolber, C. et al., Capra, V. et al.

Majumdar, Bakhtiar, Melamed, Tse,

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High impact information on Iralukast

The first phase of the response to ovalbumin was abolished by the 5-hydroxytryptamine (5-HT)2 receptor antagonist, methysergide and unaffected by the cysteinyl leukotriene receptor antagonist, iralukast [1].
In whole blood, iralukast was distributed between plasma and erythrocytes in the proportion (%) 90/10 [2].
Evaluation of the pharmacological activity of the pure cysteinyl-leukotriene receptor antagonists CGP 45715A (iralukast) and CGP 57698 in human airways [3].

Analytical, diagnostic and therapeutic context of Iralukast

Trace-level quantitation of iralukast in human plasma by microbore liquid chromatography/tandem mass spectrometry [4].
Nonetheless, plasma concentration-time profiles for patients with moderate asthma after oral administration of 200, 500, 1000, and 5000 microgram/kg/day of iralukast were successfully obtained [4].
Binding of iralukast to serum proteins and erythrocytes: measurements using ultrafiltration and an erythrocyte partitioning method [2].

References

Interaction between adenosine and allergen or compound 48/80 on lung parenchymal strips from actively sensitized Brown Norway rats. Wolber, C., Baur, F., Fozard, J.R. Eur. J. Pharmacol. (2004) [Pubmed]
Binding of iralukast to serum proteins and erythrocytes: measurements using ultrafiltration and an erythrocyte partitioning method. Colussi, D., Parisot, C., Lefèvre, G. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (1999) [Pubmed]
Evaluation of the pharmacological activity of the pure cysteinyl-leukotriene receptor antagonists CGP 45715A (iralukast) and CGP 57698 in human airways. Capra, V., Ravasi, S., Bolla, M., Viappiani, S., Pagliardini, S., Belloni, P.A., Mezzetti, M., Folco, G.C., Nicosia, S., Rovati, G.E. Adv. Exp. Med. Biol. (1999) [Pubmed]
Trace-level quantitation of iralukast in human plasma by microbore liquid chromatography/tandem mass spectrometry. Majumdar, T.K., Bakhtiar, R., Melamed, D., Tse, F.L. Rapid Commun. Mass Spectrom. (2000) [Pubmed]

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