The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Cysltr1  -  cysteinyl leukotriene receptor 1

Rattus norvegicus

Synonyms: CysLTR1, Cyslt1, Cysteinyl leukotriene receptor 1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Cysltr1

 

High impact information on Cysltr1

  • This and other previously reported proinflammatory effects of LTD4 may contribute significantly to its overall influential role in the pathophysiology of asthma, and may underlie the therapeutic benefit of CysLT receptor antagonists, such as pranlukast, in this disorder [4].
  • The leukotriene receptor B4 and the cysteinyl leukotriene receptor type 1 were selectively expressed in the glomerulus, whereas cysteinyl receptor type 2 was not found in any nephron segment [5].
  • In the ischemic core, cysteinyl leukotriene receptor 1 was primarily localized in neurons 24 h, and in macrophage/microglia 14 days after reperfusion; while in the boundary zone it was localized in proliferated astrocytes 14 days after reperfusion [1].
  • Inclusion of the selective 5-lipoxygenase inhibitor AA-861 or the cysteinyl leukotriene receptor antagonist MK-571 significantly reduced the vasoconstrictor responses to angiotensin II but not to endothelin-1 and potassium chloride [6].
  • The present study aimed to investigate the possible protective effect of montelukast, a selective antagonist of cysteinyl leukotriene receptor 1 (leukotriene CysLT1), against Escherichia coli-induced oxidative injury and scarring in renal tissue [7].
 

Biological context of Cysltr1

  • A selective CysLT(1) receptor antagonist montelukast did not affect OGD-induced apoptosis; while non-selective CysLT receptor antagonist Bay u9773 inhibited OGD-induced apoptosis, especially in CysLT(2) receptor over-expressing cells [8].
 

Anatomical context of Cysltr1

  • The effects of BAY u9773 (6(R)-(4'-carboxyphenylthio)-5(S)-hydroxy-7(E),9(E), 11(Z),14(Z)-eicosatetraenoic acid), a cysteinyl-leukotriene analogue, were investigated on a variety of smooth muscle preparations in order to determine its profile as a cysteinyl-leukotriene receptor antagonist [9].
 

Associations of Cysltr1 with chemical compounds

 

Analytical, diagnostic and therapeutic context of Cysltr1

  • We found that cysteinyl leukotriene receptor 1 mRNA expression was up-regulated in the ischemic core both 3-12 h and 7-14 days, and in the boundary zone 7-14 days after reperfusion [1].

References

  1. Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats. Fang, S.H., Wei, E.Q., Zhou, Y., Wang, M.L., Zhang, W.P., Yu, G.L., Chu, L.S., Chen, Z. Neuroscience (2006) [Pubmed]
  2. Evaluating the prophylactic potential of zafirlukast against the toxic effects of acetic acid on the rat colon. Mahgoub, A.A., El-Medany, A.A., Hager, H.H., Mustafa, A.A., El-Sabah, D.M. Toxicol. Lett. (2003) [Pubmed]
  3. ONO-1078 reduces NMDA-induced brain injury and vascular cell adhesion molecule-1 expression in rats. Zhang, L.H., Wei, E.Q. Acta Pharmacol. Sin. (2005) [Pubmed]
  4. Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody. Underwood, D.C., Osborn, R.R., Newsholme, S.J., Torphy, T.J., Hay, D.W. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  5. Gene expression of 5-, 12-, and 15-lipoxygenases and leukotriene receptors along the rat nephron. Reinhold, S.W., Vitzthum, H., Filbeck, T., Wolf, K., Lattas, C., Riegger, G.A., Kurtz, A., Krämer, B.K. Am. J. Physiol. Renal Physiol. (2006) [Pubmed]
  6. Cysteinyl leukotrienes mediate enhanced vasoconstriction to angiotensin II but not endothelin-1 in SHR. Shastri, S., McNeill, J.R., Wilson, T.W., Poduri, R., Kaul, C., Gopalakrishnan, V. Am. J. Physiol. Heart Circ. Physiol. (2001) [Pubmed]
  7. Oxidative renal damage in pyelonephritic rats is ameliorated by montelukast, a selective leukotriene CysLT1 receptor antagonist. Tuğtepe, H., Sener, G., Cetinel, S., Velioğlu-Oğünç, A., Yeğen, B.C. Eur. J. Pharmacol. (2007) [Pubmed]
  8. Distinct roles of CysLT1 and CysLT2 receptors in oxygen glucose deprivation-induced PC12 cell death. Sheng, W.W., Li, C.T., Zhang, W.P., Yuan, Y.M., Hu, H., Fang, S.H., Zhang, L., Wei, E.Q. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  9. BAY u9773, a novel antagonist of cysteinyl-leukotrienes with activity against two receptor subtypes. Tudhope, S.R., Cuthbert, N.J., Abram, T.S., Jennings, M.A., Maxey, R.J., Thompson, A.M., Norman, P., Gardiner, P.J. Eur. J. Pharmacol. (1994) [Pubmed]
  10. Interaction between adenosine and allergen or compound 48/80 on lung parenchymal strips from actively sensitized Brown Norway rats. Wolber, C., Baur, F., Fozard, J.R. Eur. J. Pharmacol. (2004) [Pubmed]
  11. Biphasic response to lipopolysaccharide from E. coli in the isolated ventilated blood-perfused rat lung. Chlopicki, S., Bartuś, J.B., Gryglewski, R.J. J. Physiol. Pharmacol. (1999) [Pubmed]
  12. Leukotrienes mediate 5-hydroxytryptamine-induced plasma extravasation in the rat knee joint via CysLT-type receptors. Wang, Y., Mitchell, J., Sharma, M., Gabriel, A., Moriyama, K., Palmer, P.P. Inflamm. Res. (2004) [Pubmed]
  13. 6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant. Levy, A.S., Simon, O., Shelly, J., Gardener, M. BMC Pharmacol. (2006) [Pubmed]
 
WikiGenes - Universities