Disease relevance of NSC25499

• The crystal structure of a thermophilic alcohol dehydrogenase (TBAD) from Thermoanaerobacter brockii has been determined in a binary complex with sec-butanol as substrate to a resolution of 3.0 A [1].
• Over a period of 10 years, 20 spina bifida occulta (S.B.O.) and 22 spina bifida aperta (S.B.A.) patients were operated [2].

High impact information on NSC25499

• The effect of temperature and concentration on the structure of sec-butyl alcohol and isobutyl alcohol/water binary mixtures in the alcohol-rich region (mole fraction of water X(H2O) < 0.3) has been studied using Fourier transform (FT) near-infrared (NIR) spectroscopy [3].
• Apparent equilibration time required for surfactant-oil-water systems to emulsify into the morphology imposed by the formulation. Part 2: Effect of sec-butanol concentration and initial location [4].
• One-step extraction and concentration of pigments and acyl lipids by sec-butanol from in vitro and in vivo samples [5].
• This type of model also allows an explanation for the peptization kinetics of systems containing sec-butanol formed during the hydrolysis of trisecbutoxyaluminium [6].
• Sensory irritation due to inhalation of n-pentanol, n-heptanol, sec-butanol and tert-pentanol was determined from the reflexively induced decrease in respiratory rate in CF-1 mice [7].

Anatomical context of NSC25499

• The foramen magnum of the skulls of children with S.B.A. was larger than in normal children [8].

Analytical, diagnostic and therapeutic context of NSC25499

• Pigments extracted with sec-butanol were indistinguishable from those extracted using acetone as determined by quantitative and qualitative HPLC [5].

References