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Chemical Compound Review

Elziverina     1-[(3,4- dimethoxyphenyl)methyl]- 6,7...

Synonyms: Elziverine, Elziverinum, SureCN195183, CHEMBL2104212, Ro-224839, ...
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Disease relevance of Ro 22-4839

  • The long-term treatment with Ro 22-4839 prevented the progress of stroke and cerebral edema, although the deteriorated cardiovascular parameters were not prevented by the treatment [1].
  • In the video camera system monitoring the constrictory response of feline pial small vessels of the parietal cortex to hypocapnia, Ro 22-4839 was found to reverse vasoconstriction of both pial arteries and veins at the dose of 0.3 mg/kg i.v./min, which did not dilate these vessels under normocapnia [2].

High impact information on Ro 22-4839


Biological context of Ro 22-4839


Anatomical context of Ro 22-4839


Associations of Ro 22-4839 with other chemical compounds

  • Vasodilating action of a new calmodulin antagonist, 6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-4-([4-(2-methoxyphenyl)- 1-piperazinyl]methyl) isoquinoline (Ro 22-4839), was examined in anesthetized animals [2].

Gene context of Ro 22-4839

  • These findings indicate that Ro 22-4839 exerts the spasmolytic effects on cerebral vessels through calmodulin antagonistic properties combined with alpha 1-adrenoceptor blocking action [5].


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