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Chemical Compound Review:

Quinotolast 4-oxo-1-phenoxy-N-(2H- tetrazol-5...

Synonyms: Quinotolastum, CHEMBL2104625, AC1L2455, AC1Q5BO1, FR 71021, ...

Kobayashi, K. et al.

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Disease relevance of FR 71021

Thus, the effect of quinotolast on type I allergic reaction would seem to be based on an inhibition of mediator release from inflammatory cells including mast cells [1].

High impact information on FR 71021

Furthermore, quinotolast potently inhibited PCA in guinea pigs in which DSCG and other reference drugs showed poor inhibitory activity [1].
Moreover, it was clearly demonstrated that quinotolast and DSCG had a cross tachyphylaxis to inhibit PCA in rats, suggesting that these drugs, at least in part, share the same mechanism of action [1].

Biological context of FR 71021

Quinotolast potently inhibited such type I allergic reactions as passive cutaneous anaphylaxis (PCA) and anaphylactic bronchoconstriction in rats by both intravenous and oral dosing [1].

References

Effects of quinotolast, a new orally active antiallergic drug, on experimental allergic models. Kobayashi, K., Hiroi, J., Kishi, S., Sawase, K., Hirayama, Y., Chihara, S., Imai, T., Shigi, Y., Shimomura, K., Kohsaka, M. Jpn. J. Pharmacol. (1993) [Pubmed]

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