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Gene Review

Pcas  -  passive cutaneous anaphylaxis

Mus musculus

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Disease relevance of Pcas


Psychiatry related information on Pcas


High impact information on Pcas


Chemical compound and disease context of Pcas


Biological context of Pcas


Anatomical context of Pcas


Associations of Pcas with chemical compounds


Regulatory relationships of Pcas


Other interactions of Pcas


Analytical, diagnostic and therapeutic context of Pcas

  • Significant PCA reactions were elicited, however, with PI-specific IgG1 from IL-12-/- or anti-IFN-gamma Ab-treated mice, although less Ab was measured by ELISA [37].
  • Depletion with anti-IL-4 antibody led to profound suppression of IgE-eosinophil-mediated antibody-dependent cell-mediated cytotoxicity and passive cutaneous anaphylaxis responses against the parasite and no effect on IgG2a antibody, Ag-mediated blast transformation, or resistance [38].
  • The recombinant protein is able to induce a passive cutaneous anaphylaxis reaction in rat, and it behaves similarly to the native Equ c1 in several immunological tests with allergic patients' IgE antibodies, mouse monoclonal antibodies, or rabbit polyclonal IgG antibodies [39].
  • The potency measured by PCA inhibition in the mouse-to-rat system was compared with that of protein nitrogen (PN) content, end point of prick test in humans, and 50% radioallergosorbent test (RAST) inhibition [40].
  • These findings are of particular interest to those who are seeking (i) to measure food-extract-specific IgE antibody in animal models and (ii) an alternative to the animal-based PCA method to measure mouse IgE antibodies [41].


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  33. Inhibition of IgE-dependent mouse triphasic cutaneous reaction by a boiling water fraction separated from mycelium of Phellinus linteus. Inagaki, N., Shibata, T., Itoh, T., Suzuki, T., Tanaka, H., Nakamura, T., Akiyama, Y., Kawagishi, H., Nagai, H. Evidence-based complementary and alternative medicine : eCAM. (2005) [Pubmed]
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  35. Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase. Kanaoka, Y., Maekawa, A., Penrose, J.F., Austen, K.F., Lam, B.K. J. Biol. Chem. (2001) [Pubmed]
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  37. Cutting edge: mouse IgG1 antibodies comprise two functionally distinct types that are differentially regulated by IL-4 and IL-12. Faquim-Mauro, E.L., Coffman, R.L., Abrahamsohn, I.A., Macedo, M.S. J. Immunol. (1999) [Pubmed]
  38. Resistance in murine schistosomiasis is contingent on activated IL-2 receptor-bearing L3T4+ lymphocytes, negatively regulated by Lyt-2+ cells, and uninfluenced by the presence of IL-4. Phillips, S.M., Lin, J.J., Galal, N., Tung, A.S., Linette, G.P., Perrin, P.J. J. Immunol. (1991) [Pubmed]
  39. cDNA cloning and sequencing reveal the major horse allergen Equ c1 to be a glycoprotein member of the lipocalin superfamily. Gregoire, C., Rosinski-Chupin, I., Rabillon, J., Alzari, P.M., David, B., Dandeu, J.P. J. Biol. Chem. (1996) [Pubmed]
  40. A new method of allergen standardization. Passive cutaneous anaphylaxis inhibition in a mouse-to-rat system in comparison with other methods. Akiyama, K., Miyamoto, T., Horiuchi, Y. J. Allergy Clin. Immunol. (1979) [Pubmed]
  41. An ELISA-based method for measurement of food-specific IgE antibody in mouse serum: an alternative to the passive cutaneous anaphylaxis assay. Birmingham, N., Payankaulam, S., Thanesvorakul, S., Stefura, B., HayGlass, K., Gangur, V. J. Immunol. Methods (2003) [Pubmed]
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