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Chemical Compound Review:

AC1LDQBC 4-[(1R,2S)-2-amino-1- hydroxy...

Synonyms: FT-0603517

Guglielmo, A. et al., Taylor, S.E. et al.

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Disease relevance of levonordefrin

Both epinephrine and levonordefrin decreased the toxicity and lethality of procaine with respect to dose [1].

High impact information on levonordefrin

CONCLUSIONS: We concluded that intraosseous injection of 1.8 mL of 2% lidocaine with 1:100,000 epinephrine or 2% mepivacaine with 1:20,000 levonordefrin, used to supplement an IAN block, significantly increased anesthetic success in first molars and second premolars [2].

Chemical compound and disease context of levonordefrin

Epinephrine, but not levonordefrin, increased the toxicity and lethality of bupivacaine as well as the lethality of tetracaine [1].

References

Modification of local anesthetic toxicity by vasoconstrictors. Taylor, S.E., Dorris, R.L. Anesthesia progress. (1989) [Pubmed]
Anesthetic efficacy and heart rate effects of the supplemental intraosseous injection of 2% mepivacaine with 1:20,000 levonordefrin. Guglielmo, A., Reader, A., Nist, R., Beck, M., Weaver, J. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (1999) [Pubmed]

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