Disease relevance of Bicuspid

• Congenital heart defects included bicuspid aortic valve (two), pulmonary valvular stenosis (one), ventricular septal defect (two), and an atrial septal defect (one) [1].
• Stenotic bicuspid aortic valve associated with a ventricular septal defect in an adult presenting with congestive heart failure: a rare observation [2].
• We designed this study to examine the potential for alternative restorative techniques for pulpless teeth, using strain gauges mounted on extracted maxillary second premolars to measure strains generated by nondestructive occlusal loading [3].
• His mother had LWD plus additional findings of Turner syndrome (TS): high arched palate, bicuspid aortic valve, aortic stenosis, and premature ovarian failure [4].
• RESULTS: Total matrix metalloproteinase-2 activity was greater in aneurysms associated with bicuspid valves when compared with those from tricuspid valves (43 +/- 11 ng/mg vs 14 +/- 2 ng/mg, P =.02) [5].

High impact information on Bicuspid

• ATD6-96 is the left half of a gracile mandible belonging to a probably female adult individual with premolars and molars in place [6].
• RESULTS: The majority of the surgically removed tricuspid and bicuspid valves expressed adhesion molecules (E-selectin, 75% and 100%; ICAM-1, 75% and 80%; VCAM-1, 69% and 60%, respectively) [7].
• However, after correction for age, height, weight, and presence of bicuspid aortic valve and coarctation, using a multiple regression, neither history of GH treatment nor the length of GH treatment had an effect on the aortic diameter [8].
• The typical lingual canal locations were the midline of the mandible and the premolar region [9].
• MSX1-associated oligodontia typically includes missing maxillary and mandibular second bicuspids and maxillary first bicuspids [10].

Chemical compound and disease context of Bicuspid

• After exclusion of wisdom teeth and premolars extracted for orthodontic reasons (intact teeth with attachment > 90%), coronal and root caries, fillings, pulp exposure and incomplete root fillings (based on X-rays) were registered [11].
• 6 beagle dogs with experimentally-induced periodontitis on the mandibular 2nd, 3rd and 4th premolars were treated with metronidazole 10% dental paste 2 x daily for 4 weeks in an open placebo-controlled study using a split-mouth design [12].
• We have previously shown that a 2-wk local infusion of bafilomycin A1, an inhibitor of vacuolar H(+)-ATPases in osteoclasts, into the crypts of erupting mandibular premolars in dogs blocks bone resorption during this period and eruption of these teeth is delayed for 8 wk [13].
• Subgroup analysis demonstrated that the association between elevated serum cholesterol concentrations and calcific aortic stenosis was particularly strong in patients with tricuspid aortic valves (6.4+/-1.2 vs. 5.3+/-1.1 mmol/l; p < 0.001) compared with those with bicuspid valves (5.9+/-1.1 vs. 5.3+/-1.1 mmol/l; p = 0.06) [14].
• After mechanical preparation and removal of smear layer, 41 human premolar teeth were stored individually in flasks containing 800 ml of ultra-pure deionized water for 2855 h [15].

Biological context of Bicuspid

• Since a missense mutation in the homeobox gene, MSX1, was previously linked to tooth agenesis in a single family lacking second premolars and third molars, we performed a mutational analysis of MSX1 by PCR [16].
• The fluoride content of the enamel and dentine of premolars was used as a determinant of the availability of ingested fluoride in New Zealand prior to and following the introduction of water fluoridation 40 years ago [17].
• Digital image analysis in dental research applied for treatment of fissures on occlusal surfaces of premolars [18].
• Cocaine inhalation triggered pain in the premolar zone of the upper jaw, followed by spread of pain to the periorbital region on the same side [19].
• The purpose of this study was to evaluate effects of periradicular lesions on osseointegration of existing implants.Study design Forty titanium solid root-form implants were placed close to premolars in dogs [20].

Anatomical context of Bicuspid

• Four of nine noted obligate carriers of hypodontia gene had dental anomalies, including small upper lateral incisors, ectopic canines, taurodontism, and rotated premolars [21].
• OBJECTIVE: This study aimed to assess extracellular matrix protein expression patterns at the convexity (right anterolateral wall) and the concavity of the dilated ascending aorta in patients with bicuspid aortic valve disease [22].
• Besides malposition of cuspids, the members also showed varying combinations of other anomalies: malposition, malformation or hypodontia of upper lateral incisors, second bicuspids and lower central incisors [23].
• Two premolars displayed the interglobular dentine in the coronal half of the root (type B) [24].
• Class V cavity preparations with occlusal margins in enamel and gingival margins in cementum were prepared both on labial and lingual surfaces of extracted premolar teeth [25].

Associations of Bicuspid with chemical compounds

• They showed more interdental spacing in the premolar regions, more anterior teeth in occlusal contact, and lower alveolar bone scores [26].
• The aim of this study was to determine the feasibility of using fatigue-testing of a complex dental restoration and to evaluate the mechanical fatigue behavior of premolar teeth restored with a titanium alloy post and an amalgam or composite core [27].
• Deafferentation was produced by endodontic removal, under sterile conditions, of the coronal pulp of the canine, premolar, and molar teeth [28].
• Tritiated proline was administered to domestic cats during the development of their permanent premolars [29].
• Autogenous dentin and bone matrix, obtained from the crowns of primary molars or maxillary cortical bone, respectively, were demineralized with 3% acetic acid and implanted into pulpal or papilla sites of erupting dog teeth: first molars, fourth premolars, and canines [30].

Gene context of Bicuspid

• Freshly exposed molar and premolar pulps were treated with varying amounts of a complex comprising hOP-1 and a carrier matrix of purified bovine type-1 collagen powder (CM) moistened with sterile saline [31].
• Mild prolongation of P-R interval in females and an increased frequency of stenotic bicuspid aortic valves were also features of the Nkx2-5 heterozygous phenotype [32].
• CONCLUSIONS: Deficient fibrillin-1 content in the vasculature of patients with bicuspid aortic valves might trigger matrix metalloproteinase production, leading to matrix disruption and dilatation [33].
• In bicuspid aortic valve disease a deficiency of fibrillin-1 and increased matrix metalloproteinase matrix degradation might result in aortic degeneration and dilatation [33].
• CONCLUSIONS: MMP-9 expression was significantly higher in bicuspid aortic valves compared to normal valves (P<0.05) [34].

Analytical, diagnostic and therapeutic context of Bicuspid

• Echocardiography reveals a high incidence of bicuspid aortic valve in Turner syndrome [35].
• Replicas of 15 premolars restored with Class II ceramic inlays at the time of placement and eight years after restoration were used for morphological measurement by means of the CCD laser scanner system [36].
• METHODS: Five mongrel dogs received apically positioned flaps, osteotomy/plasty, and RAI (restorative alveolar interface technique) on the maxillary right third bicuspid and first molar; on the same teeth on the left side, a large tissue excision similar to gingivectomy and RAI were performed [37].
• Periodontal healing after use of Atrisorb barrier material (polylactic acid) for guided tissue regeneration was studied in the premolar and molar teeth of six beagle dogs [38].
• METHODS: Coronal segments of 30 premolars, randomly allocated to three equal groups, were assessed by fluid filtration [39].

References