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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Bicuspid


High impact information on Bicuspid

  • ATD6-96 is the left half of a gracile mandible belonging to a probably female adult individual with premolars and molars in place [6].
  • RESULTS: The majority of the surgically removed tricuspid and bicuspid valves expressed adhesion molecules (E-selectin, 75% and 100%; ICAM-1, 75% and 80%; VCAM-1, 69% and 60%, respectively) [7].
  • However, after correction for age, height, weight, and presence of bicuspid aortic valve and coarctation, using a multiple regression, neither history of GH treatment nor the length of GH treatment had an effect on the aortic diameter [8].
  • The typical lingual canal locations were the midline of the mandible and the premolar region [9].
  • MSX1-associated oligodontia typically includes missing maxillary and mandibular second bicuspids and maxillary first bicuspids [10].

Chemical compound and disease context of Bicuspid

  • After exclusion of wisdom teeth and premolars extracted for orthodontic reasons (intact teeth with attachment > 90%), coronal and root caries, fillings, pulp exposure and incomplete root fillings (based on X-rays) were registered [11].
  • 6 beagle dogs with experimentally-induced periodontitis on the mandibular 2nd, 3rd and 4th premolars were treated with metronidazole 10% dental paste 2 x daily for 4 weeks in an open placebo-controlled study using a split-mouth design [12].
  • We have previously shown that a 2-wk local infusion of bafilomycin A1, an inhibitor of vacuolar H(+)-ATPases in osteoclasts, into the crypts of erupting mandibular premolars in dogs blocks bone resorption during this period and eruption of these teeth is delayed for 8 wk [13].
  • Subgroup analysis demonstrated that the association between elevated serum cholesterol concentrations and calcific aortic stenosis was particularly strong in patients with tricuspid aortic valves (6.4+/-1.2 vs. 5.3+/-1.1 mmol/l; p < 0.001) compared with those with bicuspid valves (5.9+/-1.1 vs. 5.3+/-1.1 mmol/l; p = 0.06) [14].
  • After mechanical preparation and removal of smear layer, 41 human premolar teeth were stored individually in flasks containing 800 ml of ultra-pure deionized water for 2855 h [15].

Biological context of Bicuspid


Anatomical context of Bicuspid


Associations of Bicuspid with chemical compounds

  • They showed more interdental spacing in the premolar regions, more anterior teeth in occlusal contact, and lower alveolar bone scores [26].
  • The aim of this study was to determine the feasibility of using fatigue-testing of a complex dental restoration and to evaluate the mechanical fatigue behavior of premolar teeth restored with a titanium alloy post and an amalgam or composite core [27].
  • Deafferentation was produced by endodontic removal, under sterile conditions, of the coronal pulp of the canine, premolar, and molar teeth [28].
  • Tritiated proline was administered to domestic cats during the development of their permanent premolars [29].
  • Autogenous dentin and bone matrix, obtained from the crowns of primary molars or maxillary cortical bone, respectively, were demineralized with 3% acetic acid and implanted into pulpal or papilla sites of erupting dog teeth: first molars, fourth premolars, and canines [30].

Gene context of Bicuspid


Analytical, diagnostic and therapeutic context of Bicuspid


  1. The spectrum of cardiac defects in the Ehlers-Danlos syndrome, types I and III. Leier, C.V., Call, T.D., Fulkerson, P.K., Wooley, C.F. Ann. Intern. Med. (1980) [Pubmed]
  2. Stenotic bicuspid aortic valve associated with a ventricular septal defect in an adult presenting with congestive heart failure: a rare observation. Suzuki, T., Nagai, R., Kurihara, H., Kurihara, Y., Yamazaki, T., Ho, E., Maemura, K., Shiojima, I., Yamaoki, K., Furuse, A. Eur. Heart J. (1994) [Pubmed]
  3. Stiffness of endodontically-treated teeth related to restoration technique. Reeh, E.S., Douglas, W.H., Messer, H.H. J. Dent. Res. (1989) [Pubmed]
  4. A man who inherited his SRY gene and Leri-Weill dyschondrosteosis from his mother and neurofibromatosis type 1 from his father. Wei, F., Cheng, S., Badie, N., Elder, F., Scott, C., Nicholson, L., Ross, J.L., Zinn, A.R. Am. J. Med. Genet. (2001) [Pubmed]
  5. Matrix metalloproteinase activity in thoracic aortic aneurysms associated with bicuspid and tricuspid aortic valves. Boyum, J., Fellinger, E.K., Schmoker, J.D., Trombley, L., McPartland, K., Ittleman, F.P., Howard, A.B. J. Thorac. Cardiovasc. Surg. (2004) [Pubmed]
  6. An Early Pleistocene hominin mandible from Atapuerca-TD6, Spain. Carbonell, E., Bermúdez de Castro, J.M., Arsuaga, J.L., Allue, E., Bastir, M., Benito, A., Cáceres, I., Canals, T., Díez, J.C., van der Made, J., Mosquera, M., Ollé, A., Pérez-González, A., Rodríguez, J., Rodríguez, X.P., Rosas, A., Rosell, J., Sala, R., Vallverdú, J., Vergés, J.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Adhesion molecules in nonrheumatic aortic valve disease: endothelial expression, serum levels and effects of valve replacement. Ghaisas, N.K., Foley, J.B., O'Briain, D.S., Crean, P., Kelleher, D., Walsh, M. J. Am. Coll. Cardiol. (2000) [Pubmed]
  8. Growth hormone treatment and aortic dimensions in turner syndrome. Bondy, C.A., Van, P.L., Bakalov, V.K., Ho, V.B. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  9. Lingual vascular canals of the mandible: evaluation with dental CT. Gahleitner, A., Hofschneider, U., Tepper, G., Pretterklieber, M., Schick, S., Zauza, K., Watzek, G. Radiology. (2001) [Pubmed]
  10. Novel MSX1 Frameshift Causes Autosomal-dominant Oligodontia. Kim, J.W., Simmer, J.P., Lin, B.P., Hu, J.C. J. Dent. Res. (2006) [Pubmed]
  11. Periodontal attachment level of extractions presumably performed for periodontal reasons. Splieth, C., Giesenberg, J., Fanghanel, J., Bernhardt, O., Kocher, T. Journal of clinical periodontology. (2002) [Pubmed]
  12. The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog. Klinge, B., Kuvatanasuhati, J., Attström, R., Kalfas, S., Edwardsson, S. Journal of clinical periodontology. (1992) [Pubmed]
  13. Bafilomycin A1 in bone resorption and tooth eruption in dogs. Marks, S.C., Sundquist, K.T. Eur. J. Oral Sci. (1995) [Pubmed]
  14. Association between calcific aortic stenosis and hypercholesterolemia: is there a need for a randomized controlled trial of cholesterol-lowering therapy? Chui, M.C., Newby, D.E., Panarelli, M., Bloomfield, P., Boon, N.A. Clinical cardiology. (2001) [Pubmed]
  15. Ca2+ diffusion through dentin of Ca(OH)2 associated with seven different vehicles. Camões, I.C., Salles, M.R., Chevitarese, O. Journal of endodontics. (2003) [Pubmed]
  16. Clinical, radiographic, and genetic evaluation of a novel form of autosomal-dominant oligodontia. Goldenberg, M., Das, P., Messersmith, M., Stockton, D.W., Patel, P.I., D'Souza, R.N. J. Dent. Res. (2000) [Pubmed]
  17. Fluoride content of the enamel and dentine of human premolars prior to and following the introduction of fluoridation in New Zealand. Cutress, T.W., Coote, G.E., Shu, M., Pearce, E.I. Caries Res. (1996) [Pubmed]
  18. Digital image analysis in dental research applied for treatment of fissures on occlusal surfaces of premolars. Kaczmarek, E., Matthews-Brzozowska, T., Miskowiak, B. Annals of biomedical engineering. (2003) [Pubmed]
  19. Cluster headache and cocaine use. Peñarrocha, M., Bagán, J.V., Peñarrocha, M.A., Silvestre, F.J. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2000) [Pubmed]
  20. Effect of teeth with periradicular lesions on adjacent dental implants. Shabahang, S., Bohsali, K., Boyne, P.J., Caplanis, N., Lozada, J., Torabinejad, M. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. (2003) [Pubmed]
  21. Characteristics of incisor-premolar hypodontia in families. Arte, S., Nieminen, P., Apajalahti, S., Haavikko, K., Thesleff, I., Pirinen, S. J. Dent. Res. (2001) [Pubmed]
  22. Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: preliminary results. Cotrufo, M., Della Corte, A., De Santo, L.S., Quarto, C., De Feo, M., Romano, G., Amarelli, C., Scardone, M., Di Meglio, F., Guerra, G., Scarano, M., Vitale, S., Castaldo, C., Montagnani, S. J. Thorac. Cardiovasc. Surg. (2005) [Pubmed]
  23. Dominant inheritance of tooth malpositions and their association to hypodontia. Svinhufvud, E., Myllärniemi, S., Norio, R. Clin. Genet. (1988) [Pubmed]
  24. Distribution of interglobular dentine in human tooth roots. Sato, H., Kagayama, M., Sasano, Y., Mayanagi, H. Cells Tissues Organs (Print) (2000) [Pubmed]
  25. Microleakage of light-cured resin and resin-modified glass-ionomer dentin bonding agents applied with co-cure vs pre-cure technique. Tulunoglu, O., Uçtaşh, M., Alaçam, A., Omürlü, H. Operative dentistry. (2000) [Pubmed]
  26. Occlusal stability in shortened dental arches. Witter, D.J., Creugers, N.H., Kreulen, C.M., de Haan, A.F. J. Dent. Res. (2001) [Pubmed]
  27. Fatigue behavior of direct post-and-core-restored premolars. Huysmans, M.C., van der Varst, P.G., Schäfer, R., Peters, M.C., Plasschaert, A.J., Soltész, U. J. Dent. Res. (1992) [Pubmed]
  28. Tooth pulp deafferentation is associated with functional alterations in the properties of neurons in the trigeminal spinal tract nucleus. Hu, J.W., Dostrovsky, J.O., Lenz, Y.E., Ball, G.J., Sessle, B.J. J. Neurophysiol. (1986) [Pubmed]
  29. Radiochemical determination of the metabolic activity of collagen in mature dentin. Borggreven, J.M., Hoppenbrouwers, P.M., Gorissen, R. J. Dent. Res. (1979) [Pubmed]
  30. Inductive influences of demineralized dentin and bone matrix on pulp cells: an approach of secondary dentinogenesis. Tziafas, D., Kolokuris, I. J. Dent. Res. (1990) [Pubmed]
  31. Induction of reparative dentine formation in monkeys by recombinant human osteogenic protein-1. Rutherford, R.B., Wahle, J., Tucker, M., Rueger, D., Charette, M. Arch. Oral Biol. (1993) [Pubmed]
  32. Cardiac septal and valvular dysmorphogenesis in mice heterozygous for mutations in the homeobox gene Nkx2-5. Biben, C., Weber, R., Kesteven, S., Stanley, E., McDonald, L., Elliott, D.A., Barnett, L., Köentgen, F., Robb, L., Feneley, M., Harvey, R.P. Circ. Res. (2000) [Pubmed]
  33. Vascular matrix remodeling in patients with bicuspid aortic valve malformations: implications for aortic dilatation. Fedak, P.W., de Sa, M.P., Verma, S., Nili, N., Kazemian, P., Butany, J., Strauss, B.H., Weisel, R.D., David, T.E. J. Thorac. Cardiovasc. Surg. (2003) [Pubmed]
  34. Tissue microarray detection of matrix metalloproteinases, in diseased tricuspid and bicuspid aortic valves with or without pathology of the ascending aorta. Koullias, G.J., Korkolis, D.P., Ravichandran, P., Psyrri, A., Hatzaras, I., Elefteriades, J.A. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2004) [Pubmed]
  35. Echocardiography reveals a high incidence of bicuspid aortic valve in Turner syndrome. Miller, M.J., Geffner, M.E., Lippe, B.M., Itami, R.M., Kaplan, S.A., DiSessa, T.G., Isabel-Jones, J.B., Friedman, W.F. J. Pediatr. (1983) [Pubmed]
  36. Quantitative measurement of marginal disintegration of ceramic inlays. Hayashi, M., Tsubakimoto, Y., Takeshige, F., Ebisu, S. Operative dentistry. (2004) [Pubmed]
  37. Preprosthetic periodontal surgery in the interproximal area with modification of the COL area: anatomic and histologic study in dogs. Novaes, A.B., Novaes, A.B., De Oliveira, P.T. J. Periodontol. (2001) [Pubmed]
  38. Periodontal healing after guided tissue regeneration with Atrisorb barriers in beagle dogs. Polson, A.M., Southard, G.L., Dunn, R.L., Polson, A.P., Yewey, G.L., Swanbom, D.D., Fulfs, J.C., Rodgers, P.W. The International journal of periodontics & restorative dentistry. (1995) [Pubmed]
  39. A fluid filtration and clearing technique to assess microleakage associated with three dentine bonding systems. Youngson, C.C., Jones, J.C., Fox, K., Smith, I.S., Wood, D.J., Gale, M. Journal of dentistry. (1999) [Pubmed]
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