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Chemical Compound Review:

Ucedorm 5-(2-bromoprop-2-enyl)-5- prop-2-enyl-1,3...

Synonyms: Vesperone, Bralobarbital, Brallobarbital, CHEMBL2106093, AC1Q6GCD, ...

de Groot, G. et al., Yih, T.D. et al., Coudoré, F. et al.

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Disease relevance of Brallobarbital

We considered the use of hemoperfusion in the treatment of severe intoxications frequently seen in the Netherlands, primarily involving barbiturates and especially Vesparax (a combination of secobarbital, brallobarbital and hydroxyzine HCl) overdoses [1].

High impact information on Brallobarbital

Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication [2].

Analytical, diagnostic and therapeutic context of Brallobarbital

This suggests that a metabolite, formed especially after oral administration, is responsible for the retarded elimination of brallobarbital [2].
Identification of each barbiturate is by retention time relative to brallobarbital, confirmed using another wide-bore column of slightly different polarity, connected to a flame-ionization detector [3].

References

An evaluation of the use of hemoperfusion in acute poisoning. de Groot, G., Maes, R.A., van Heijst, A.N. Veterinary and human toxicology. (1979) [Pubmed]
Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication. Yih, T.D., Rossum, J.M. Xenobiotica (1976) [Pubmed]
Rapid toxicological screening of barbiturates in plasma by wide-bore capillary gas chromatography and nitrogen-phosphorus detection. Coudoré, F., Alazard, J.M., Paire, M., Andraud, G., Lavarenne, J. Journal of analytical toxicology. (1993) [Pubmed]

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