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Chemical Compound Review:

Tolnidamide 1-[(4-chloro-2-methyl- phenyl)methyl]indazo...

Synonyms: Tolnidamine, Tolnidamino, Tolnidaminum, CHEMBL2107293, SureCN1604178, ...

Spitz, I.M. et al., Ansari, A.S. et al., Rossi, V. et al., Lohiya, N.K. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of AF 1923

The second and third groups (B and C) of animals were administered tolnidamine orally at 50 mg/kg body weight/week and 50 mg/kg body weight/day, respectively, for a period of 150 days [1].

High impact information on AF 1923

The differential effects of the indazole-carboxylic acid derivative, tolnidamine, on Sertoli cell protein secretion [2].
The effects of the indazole carboxylic acid derivative, tolnidamine, on testicular function: I. Early changes in androgen binding protein secretion in the rat [3].
With increasing doses of tolnidamine, there was a reduction in epididymal rABP concomitant with an increase in testis and serum rABP levels.(ABSTRACT TRUNCATED AT 250 WORDS)[3]
In conclusion, tolnidamine medication induced irreversible inhibition of spermatogenesis [4].

References

Long-term sequelae of tolnidamine on male reproduction and general body metabolism in rabbits. Ansari, A.S., Kumar, Y., Srivastava, S., Lohiya, N.K. Contraception. (1998) [Pubmed]
The differential effects of the indazole-carboxylic acid derivative, tolnidamine, on Sertoli cell protein secretion. Rossi, V., Cheng, C.Y., Gunsalus, G.L., Bardin, C.W., Spitz, I.M. J. Androl. (1989) [Pubmed]
The effects of the indazole carboxylic acid derivative, tolnidamine, on testicular function: I. Early changes in androgen binding protein secretion in the rat. Spitz, I.M., Gunsalus, G.L., Mather, J.P., Thau, R., Bardin, C.W. J. Androl. (1985) [Pubmed]
Antispermatogenic effects of tolnidamine in langur (Presbytis entellus). Lohiya, N.K., Ansari, A.S., Scorza Barcellona, P. Contraception. (1991) [Pubmed]

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